The Pharma Data

JANUARY 23, 2021

On a larger scale, the tool may greatly aid existing and future TNBC studies that are currently exploring new therapies for targeted treatments. TNBC is an incredibly challenging and aggressive form of breast cancer compared to other subtypes and holds a relatively poor prognosis primarily due to a lack of targeted treatments.

Treatment 52

Treatment Cell Biology Hospitals Clinical Trials 52

Drug Target Review

DECEMBER 21, 2023

mRNA biology has become widely recognised as a new “drug mine” RNAi drugs are in the market and mRNA vaccines, initially developed for Covid-19, are already in trials for cancer. There must be something different in those diseased cells, some dysregulated pathway that is causing that disease phenotype.

Disease 105

Disease Small Molecule Vaccine Drugs 105

DrugBank

JUNE 27, 2023

The general notion is that patients should be viewed individually, rather than strictly as members of some larger general population, and that their specific genetic background, environment, and lifestyle choices should be considered throughout drug development to the point of treatment and continuing patient care.

Disease 98

Disease Treatment Drugs Clinical Trials 98

Codon

APRIL 9, 2023

The CAR-T cells were detectable in 26 out of 27 children after 30 months. Of those, 17 children responded to the treatment, and the 3-year overall survival rate was 60 percent. Read Probe-based bacterial single-cell RNA sequencing predicts toxin regulation. Current Biology. ACS Synthetic Biology.

Therapies 52

Therapies RNA Engineering Vaccine 52

Codon

APRIL 2, 2023

Mice and human cells that were given the therapy had normal levels of the survival motor neuron protein, and no symptoms. When delivered using AAV9 in mice, the treatment significantly improved motor function and extended average lifespan. An open-source FACS automation system for high-throughput cell biology. Wiener D.M.

DNA 52

DNA RNA Engineering Licensing 52

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

Production 62

Production DNA RNA Regulations 62

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. A new paper engineers a communication network between cells using DNA instead. .” Synthetic Biology. Read The F.D.A.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. A new paper engineers a communication network between cells using DNA instead. .” Synthetic Biology. Read The F.D.A.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

SEPTEMBER 22, 2024

They achieved this by treating mouse fetal ovaries with an enzyme mixture to break them apart into single cells, isolating the ovarian supporting cells, and mixing them with human PGC-like cells to form aggregates, which were then cultured in liquid media for up to 120 days.

DNA 106

DNA Laboratories Regulations Therapies 106

Broad Institute

JULY 28, 2023

Our pilot study will span: 1) high-resolution EM (electron microscopy) of synaptic excitatory-inhibitory (E-I) balance and nearby glial cells; 2) functional electrophysiological signatures of altered E-I balance by sex in ACC brain slices; 3) molecular correlates of these impairments that can be targeted for recovery of function.

Medical Schools 52

Medical Schools Hospitals Regulations Research 52

Broad Institute

NOVEMBER 21, 2024

Researchers identify source of a brain cancer’s deadly transformation By Corie Lok November 21, 2024 Breadcrumb Home Researchers identify source of a brain cancer’s deadly transformation Slow-growing glioma tumors become more aggressive when their cells shift identities and acquire new genetic mutations. Nature Cancer.

Research 124

Research Medical Schools DNA Hospitals 124

Drug Target Review

APRIL 1, 2025

Advances in biotechnology are driving significant progress in the treatment of rare diseases, making it possible to develop targeted therapies for previously untreatable conditions. I then took over management of a research group, initially running cell biology research and then preclinical development.”

Disease 52

Disease Therapies Clinical Trials Cell Biology 52

BMG Labtech

FEBRUARY 24, 2025

Post-translational modification of proteins, which includes the alteration of certain amino acid side chains by the introduction of different chemical groups, takes place in eukaryotic and prokaryotic cells. For example, it may result in changes to cell metabolism or lead to alterations in crucial signaling events.

Small Molecule 52

Small Molecule Disease Licensing Licensing 52

SugarCone Biotech

MAY 28, 2019

Learnings regarding immune geography and cell:cell contact are increasingly important as we consider how best to advance cell therapies for diverse hematologic malignancies and solid tumors ( www.aletabio.com ). The immune system is tightly regulated and unkind to inappropriate signals. Fc-hacking immune responses.

Immune Response 52

Immune Response Therapies Engineering Drug Development 52

Codon

APRIL 16, 2023

Read Deep learning of genomic contexts predicts protein co-regulation and function. Cell Reports. Read RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Nature Cell Biology. Rea Chromatin context-dependent regulation and epigenetic manipulation of prime editing. Cell Reports.

Engineering 52

Engineering DNA RNA Science 52

Codon

NOVEMBER 1, 2024

Amodei also imagines the ways AI could accelerate biological research and yield miraculous cures in the 21st century; everything from the prevention and treatment of nearly all infectious and inherited diseases to the elimination of most cancers. It demands protocols, regulations, and collaborative efforts between human beings.

DNA 118

DNA RNA Molecular Biology Laboratories 118