Drug Target Review

DECEMBER 21, 2023

mRNA biology has become widely recognised as a new “drug mine” RNAi drugs are in the market and mRNA vaccines, initially developed for Covid-19, are already in trials for cancer. There must be something different in those diseased cells, some dysregulated pathway that is causing that disease phenotype.

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Disease Small Molecule Vaccine Drugs 105

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. A new paper engineers a communication network between cells using DNA instead. .” Synthetic Biology. difficile therapy.

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Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. A new paper engineers a communication network between cells using DNA instead. .” Synthetic Biology. difficile therapy.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 9, 2023

Read Probe-based bacterial single-cell RNA sequencing predicts toxin regulation. Current Biology. ACS Synthetic Biology. A programmable and red light-regulated CRISPR-dCas9 system for the activation of endogenous genes in Saccharomyces cerevisiae. ACS Synthetic Biology. Nature Cell Biology.

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Therapies RNA Engineering Vaccine 52

Codon

SEPTEMBER 22, 2024

They achieved this by treating mouse fetal ovaries with an enzyme mixture to break them apart into single cells, isolating the ovarian supporting cells, and mixing them with human PGC-like cells to form aggregates, which were then cultured in liquid media for up to 120 days.

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DNA Laboratories Regulations Therapies 117

Codon

APRIL 16, 2023

Read Deep learning of genomic contexts predicts protein co-regulation and function. Cell Reports. Read RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Nature Cell Biology. Rea Chromatin context-dependent regulation and epigenetic manipulation of prime editing. BMC Bioinformatics.

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Engineering DNA RNA Science 52

Drug Target Review

APRIL 1, 2025

Co-founder and CEO Dr Dan Williams brings over 20 years of experience in biochemistry and drug development, with a strong background in research and clinical trials. His expertise has positioned SynaptixBio to advance its drug candidates toward clinical trials. Advances in gene expression and delivery technologies.

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Disease Therapies Clinical Trials Cell Biology 52

Broad Institute

NOVEMBER 21, 2024

said study senior author Brad Bernstein , an institute member at Broad and director of the Gene Regulation Observatory at Broad. “We We found that IDH mutations are like a ticking time bomb that allows brain tumor cells to grow slowly and hide from the immune system while they acquire more dangerous mutations. Nature Cancer.

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Research Medical Schools DNA Hospitals 124

SugarCone Biotech

MAY 28, 2019

Learnings regarding immune geography and cell:cell contact are increasingly important as we consider how best to advance cell therapies for diverse hematologic malignancies and solid tumors ( www.aletabio.com ). The immune system is tightly regulated and unkind to inappropriate signals. Fc-hacking immune responses.

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Immune Response Therapies Engineering Drug Development 52

Codon

NOVEMBER 1, 2024

.” However, it isn’t clear that such a superintelligence could even be applied to its full potential in biology today, given the dearth of high-quality datasets needed to train it. Still, many of the bottlenecks slowing biology today are biophysical , rather than computational. Subscribe to Asimov Press. Even the humble E.

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