Cell Biology Research RNA 
Broad Institute
OCTOBER 11, 2023
By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. Omar Avila Monge puts samples — immune cells isolated from tumors treated with the PTPN2 inhibitor — into a centrifuge.
Broad Institute
OCTOBER 28, 2024
By Corie Lok October 28, 2024 Credit: Ricardo Job-Reese, Broad Communications One of the first steps for researchers in studying and analyzing single cells is to determine the cells’ identity: what type and subtype of cells are these, and how similar or different are they to previously analyzed cells?
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Codon
FEBRUARY 20, 2024
More than two decades ago, though, some researchers in Tsukuba, Japan figured out a way to get around this problem and watch ATP synthase as it spins. Their experiment stands out as among the most beautiful in the history of biology. In 2008, researchers at UC Berkeley devised an ingenious solution. But again, how do we know?
Drug Target Review
JULY 23, 2024
Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. Mentors are essential for growth, especially as they provided a trusted resource to help navigate new research frontiers and obstacles.
Drug Target Review
APRIL 9, 2024
How has nucleolar stress (NS) been linked to age-related diseases, and what approach did researchers use to investigate its toxicity? In a previous study, we showed that these peptides decorate all cellular RNAs and thus impair the binding of RNA-binding proteins to RNA.
Drug Target Review
OCTOBER 2, 2024
By harvesting, expanding, and injecting CD34+ cells directly to the heart muscle, this natural repair mechanism is enhanced. Early-phase clinical trials have shown the safety and efficacy of using stem cells for cardiac repair, encouraging further research and development.
Drug Target Review
AUGUST 10, 2023
A breakthrough study conducted by researchers at the Keck School of Medicine of USC has shown a remarkable finding: during moments of stress, cancer cells undergo a transformative process. A crucial protein within these cells migrates to the nucleus, effectively reprogramming them to exhibit increased mobility and invasiveness.
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