Drug Target Review

DECEMBER 21, 2023

mRNA biology has become widely recognised as a new “drug mine” RNAi drugs are in the market and mRNA vaccines, initially developed for Covid-19, are already in trials for cancer. All of these are novel targets to be explored in small molecule drug discovery as well as for improving the efficacy of mRNA vaccines.

Disease 105

Disease Small Molecule Vaccine Drugs 105

Drug Target Review

AUGUST 10, 2023

A breakthrough study conducted by researchers at the Keck School of Medicine of USC has shown a remarkable finding: during moments of stress, cancer cells undergo a transformative process. A crucial protein within these cells migrates to the nucleus, effectively reprogramming them to exhibit increased mobility and invasiveness.

Cell Biology 52

Cell Biology Small Molecule Regulations Engineering 52

BMG Labtech

NOVEMBER 21, 2023

Effectors of signal transmission events Second messengers are small molecules or ions that transmit signals received at the cell surface to the inside environment of the cell (Fig.

Small Molecule 40

Small Molecule Regulations Research Cell Biology 40

The Pharma Data

OCTOBER 19, 2020

a multinational pharmaceutical company, where he was the head of Research & Development and responsible for the R&D strategy (France). At Aduro, he was responsible for all manufacturing and supply chain activities for the company’s biologics and small molecules and managed a transatlantic team. Kenilworth, N.J.,

Trials 40

Trials Small Molecule Cell Biology Clinical Trials 40

Elrig

APRIL 29, 2024

With a background in Bioinformatics and Computational Biology, she has a keen interest in using technology to solve problems in healthcare and medicine. Miguel Gancedo Rodrigo Miguel Gancedo Rodrigo Research Investigator, Isomorphic Labs My name is Miguel, and I’m from Murcia, Spain.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. ” — Samuel Butler , 1878 (* = My picks) AI + Bio Characterizing the interaction conformation between T-cell receptors and epitopes with deep learning. Nucleic Acids Research. Esyunina D.

DNA 52

DNA RNA Engineering Licensing 52

Codon

APRIL 30, 2023

This study sheds light on how, exactly, AI-generated text differs from the real stuff, and how it could be used to (soon) write entire research papers. Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Cell Systems.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

This study sheds light on how, exactly, AI-generated text differs from the real stuff, and how it could be used to (soon) write entire research papers. Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Cell Systems.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 16, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. AI + Bio *Emergent autonomous scientific research capabilities of large language models. Nature Cell Biology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design.

Engineering 52

Engineering DNA RNA Science 52

Drug Target Review

JANUARY 16, 2025

Traditionally, drug discovery has focused on small-molecule therapeutics, typically with a molecular weight of less than 500 Daltons. 2 Typically, small-molecule drugs target active sites buried inside proteins. However, it remains challenging to design antibodies that cross cell membranes.

Drug Development 52

Drug Development Small Molecule Drugs FDA Approval 52

BMG Labtech

FEBRUARY 24, 2025

The introduction of a nitro- group into a protein molecule is also implicated in different diseases including cardiovascular disease , lung disease, diabetes, cancer and some neurodegenerative conditions. The nitration of proteins can significantly modify both the structural and catalytic roles of these molecules. The assay (Fig.

Small Molecule 52

Small Molecule Disease Licensing Licensing 52

Codon

APRIL 8, 2025

Yet in 1982, after ten years of research, Stanley Prusiner and his San Francisco research team made a revolutionary discovery while studying sheep infected with scrapie, a fatal neurological disease. Other researchers, such as MIT’s Susan Lindquist , elaborated on Prusiner’s discovery by studying prions in new contexts.

RNA 67

RNA DNA Laboratories Virus 67

Drug Target Review

MARCH 26, 2025

Likarda initially developed CSS to overcome the lack of effective delivery systems for cell therapies. It subsequently demonstrated promise for the administration of peptides, monoclonal antibodies and small molecules. He completed a research fellowship and his residency in plastic surgery.

Therapies 52

Therapies Compliance Treatment Small Molecule 52