Chemical Biology and Drug Design

JULY 27, 2023

Effects of circ_0002375 on cisplatin-resistant NPC cells: After cisplatin treatment, circ_0002375 knockdown was transfected into cisplatin-resistant SUNE1/5-8F cells, which led to the inhibition of cisplatin resistance via down-regulating EIF5A2 that mediated by up-regulated miR-577.

Cell Biology 100

Cell Biology Regulations Treatment Research 100

Chemical Biology and Drug Design

JANUARY 5, 2024

Following the treatment of 0, 1.94, 7.75, or 19.36 μM μM THA, CRC cell viability, apoptosis, migration, and invasion were evaluated by methyl tetrazolium, flow cytometry, wound-healing, and transwell assays. μM THA dwindled CRC cell viability, migration, and invasion, and facilitated apoptosis.

Bioinformatics 100

Bioinformatics Cell Biology Treatment Research 100

Drug Target Review

NOVEMBER 24, 2023

Promise of new diagnostics and treatment New approaches may be found for diagnosing and treating a range of brain disorders, such as schizophrenia , by creating a connectome of the human brain. The hippocampus , positioned in the temporal lobe, is phylogenetically one of the oldest parts of the brain and forms part of the limbic system.

Cell Biology 105

Cell Biology Engineering Research Treatment 105

Drug Target Review

APRIL 12, 2024

Controlling the amount of RNP entering each cell is challenging, leading to uncertainty about the ratio of RNP that reaches any specific cell. Importantly for the researcher, there is no assurance that the RNP, once inside the cells, will reliably enter their nuclei.

Cell Biology 105

Cell Biology FDA Approval FDA Research 105

The Pharma Data

DECEMBER 31, 2020

Researchers at Stanford Medicine found that COVID-19 antibodies preferentially target different parts of the SARS-CoV-2 virus in mild COVID-19 cases than they do in severe cases. Adult brains undergo similar treatment, but it’s not well understood why adult synapses are eliminated. Here’s a look at some of the more interesting ones.

Research 52

Research Virus Immune Response Cell Biology 52

Drug Target Review

APRIL 12, 2024

Controlling the amount of RNP entering each cell is challenging, leading to uncertainty about the ratio of RNP that reaches any specific cell. Importantly for the researcher, there is no assurance that the RNP, once inside the cells, will reliably enter their nuclei.

Cell Biology 98

Cell Biology FDA Approval FDA Research 98

Drug Target Review

JULY 23, 2024

Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. Mentors are essential for growth, especially as they provided a trusted resource to help navigate new research frontiers and obstacles.

Small Molecule 116

Small Molecule Targeted Protein Degradation Science Disease 116

Drug Target Review

AUGUST 24, 2023

We will explore how GDF-15 impacts the tumour microenvironment and hinders the infiltration of T cells into the tumour, as well as the implications of neutralising GDF-15 to reverse its inhibitory effects and sensitise tumours to anti-PD-1 treatment. T-cell infiltration is a prerequisite for responses to checkpoint inhibitors.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

KIF1A

MAY 24, 2023

The approach often focuses the patient-voice around a common goal of treatment, be it to inform a clinical endpoint or identify patient demographics for a drug treatment. It’s an investment in the long-term success of rare disease research, even if it doesn’t provide an immediate clinical on-ramp. What Can We Learn From A Worm?

Disease 98

Disease Laboratories Research Science 98

Drug Target Review

DECEMBER 21, 2023

A recently published study 1 from a large team of cell biologists sheds new light on cellular organisation and variability. Can you give a brief overview of your research methods? SR: This project started in the early days of the Allen Institute for Cell Science, nearly seven years ago.

International 105

International Science Disease Research 105

Drug Target Review

JANUARY 30, 2024

Considering the translational potential of this research to clinical applications, what are the key preclinical findings that present the 3A5C7 monoclonal antibody as a promising therapeutic option for managing morphine tolerance in humans? Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.

Treatment 52

Treatment Doctors Cell Biology Regulations 52

Drug Target Review

OCTOBER 2, 2024

Cell and gene therapies (CGTs) have made significant advancements in treating oncological diseases, with therapies like CAR-T cell treatments transforming cancer care. By harvesting, expanding, and injecting CD34+ cells directly to the heart muscle, this natural repair mechanism is enhanced.

Therapies 98

Therapies Disease Engineering RNA 98

Drug Target Review

JUNE 7, 2024

The proof for this came with the approval of KIMMTRAK (tebentafusp-tebn) by the FDA in 2022 for the treatment of HLA-A*02:01+ metastatic or unresectable uveal melanoma, a historically “cold” tumour known to be resistant to current available checkpoint immunotherapies.

Engineering 81

Engineering Clinical Trials Therapies Cell Biology 81

PerkinElmer

JANUARY 21, 2022

1 To address the urgent need for new therapies, the UK’s Medical Research Council (MRC), a national public agency supporting health science and research, established the Dementias Platform United Kingdom (DPUK) in 2014. We are intent on developing a one-stop-shop portal for global researchers,” Prof.

Cell Biology 52

Cell Biology Disease Treatment Science 52

Drug Target Review

OCTOBER 31, 2023

When I was studying cell biology, looking at how cells divide, I couldn’t fathom how math could possibly fit into that. My undergraduate studies focused on biochemistry and cell biology, so very much STEM-based, but my professors and mentors noticed my penchant for critical thinking which led me to consider law.

Cell Biology 107

Cell Biology Pharmaceuticals Science Disease 107

The Pharma Data

SEPTEMBER 21, 2020

Investors include SV Health Investors and Cancer Research UK. A biotech company spun out of the University of Edinburgh will utilise research to develop new gene therapies to target different types of cancer. I am delighted to be leading such an exciting company,” said Dr Bekkali.

Therapies 52

Therapies Cell Biology Licensing Licensing 52

Drug Target Review

AUGUST 10, 2023

A breakthrough study conducted by researchers at the Keck School of Medicine of USC has shown a remarkable finding: during moments of stress, cancer cells undergo a transformative process. A crucial protein within these cells migrates to the nucleus, effectively reprogramming them to exhibit increased mobility and invasiveness.

Cell Biology 52

Cell Biology Small Molecule Regulations Engineering 52

Broad Institute

FEBRUARY 29, 2024

Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram. Senior Research Scientist Michal Lipinski is a senior research scientist at the Spatial Technology Platform of the Broad Institute of MIT and Harvard, where he works under the supervision of Sami Farhi. Nat Methods. 2021;18(11):1352-1362.

Cell Biology 52

Cell Biology Disease Science Treatment 52

Drug Target Review

JUNE 29, 2023

Could you share an example of a specific project or some research that you have worked on and the impact it has had in your field? How has your research in STEM contributed to advancements or improvements in your field, and what potential future applications or implications do you foresee based on your work?

Therapies 115

Therapies Science Production Cell Biology 115

The Pharma Data

FEBRUARY 24, 2022

Researchers at the University of North Carolina at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center have uncovered a new role of a chromatin-modulatory enzyme, termed EZH2, during cancer development. Their findings are published online in Nature Cell Biology.

Small Molecule 52

Small Molecule Cell Biology Research Drug Development 52

The Pharma Data

MARCH 15, 2022

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet in Sweden have now found an unusual way of stabilising the protein and making it more potent.

Cell Biology 52

Cell Biology DNA Research Vaccine 52

The Pharma Data

MARCH 25, 2022

Researchers at Karolinska Institutet in Sweden have developed a novel strategy for identifying potent miniature antibodies, so-called nanobodies, against emerging SARS-CoV-2 variants. The approach led to the discovery of multiple nanobodies that in cell cultures and mice effectively blocked infection with different SARS-CoV-2 variants.

Molecular Biology 52

Molecular Biology Laboratories Cell Biology Science 52

Precision for Medicine

APRIL 7, 2023

This provides value to researchers executing clinical trials, particularly those developing novel therapeutics and vaccines, where sample processing requires geographical proximity to the trial site and samples need to be processed within hours of collecting them from patients.

Laboratories 52

Laboratories Clinical Research Clinical Trials Cell Biology 52

The Pharma Data

NOVEMBER 17, 2021

Now, new research led by investigators at Harvard Medical School and Boston Children’s Hospital points to a well-known and widely available drug called disulfiram as a possible treatment for COVID-19. I wanted to help them take their research one step further.” In the retrospective study, published Oct.

Virus 52

Virus Drugs Clinical Trials Medical Schools 52

DrugBank

JUNE 27, 2023

The general notion is that patients should be viewed individually, rather than strictly as members of some larger general population, and that their specific genetic background, environment, and lifestyle choices should be considered throughout drug development to the point of treatment and continuing patient care.

Disease 98

Disease Treatment Drugs Clinical Trials 98

Codon

OCTOBER 22, 2024

He suggests that peer review doesn’t “do the thing it’s supposed to do” — namely, “catch bad research and prevent it from being published,” so perhaps scientists would be better off uploading PDFs to the internet where review and oversight can happen post-publication. Some politicians, such as Rep.

Science 108

Science Research Government Cell Biology 108

The Pharma Data

JANUARY 23, 2021

On a larger scale, the tool may greatly aid existing and future TNBC studies that are currently exploring new therapies for targeted treatments. TNBC is an incredibly challenging and aggressive form of breast cancer compared to other subtypes and holds a relatively poor prognosis primarily due to a lack of targeted treatments.

Treatment 52

Treatment Cell Biology Hospitals Clinical Trials 52

Drug Target Review

DECEMBER 21, 2023

There must be something different in those diseased cells, some dysregulated pathway that is causing that disease phenotype. And since mRNA biology is like the highway of cell biology, it would likely be visible there. It provides major new insights into underlying disease biology.

Disease 105

Disease Small Molecule Vaccine Drugs 105

Drug Target Review

MAY 22, 2023

A recently published study 1 from a large team of cell biologists sheds new light on cellular organisation and variability. Can you give a brief overview of your research methods? This project started in the early days of the Allen Institute for Cell Science, nearly seven years ago.

International 59

International Science Disease Research 59

The Pharma Data

OCTOBER 19, 2020

an emerging leader focused on the treatment of kidney disease, sepsis and organ injury, today announced the appointment of Maarten Kraan, M.D., a multinational pharmaceutical company, where he was the head of Research & Development and responsible for the R&D strategy (France). in Cell Biology from Utrecht University.

Trials 40

Trials Small Molecule Cell Biology Clinical Trials 40

The Pharma Data

JANUARY 3, 2021

We are very honored to have someone of Dr. Zeldis’ caliber lead our scientific research and clinical development teams. In addition, their collective research insights will greatly enhance existing efforts to translate the scientific potential of our AIM technology into therapies designed to address significant unmet patient needs.”.

Immune Response 40

Immune Response Clinical Trials Therapies Cell Biology 40

NIH Director's Blog: Drug Discovery

APRIL 11, 2017

Now, NIH researchers and their collaborators have discovered a new kind of treatment that holds promise for fighting parasitic roundworms. A bonus of this result is that this same treatment might work also for certain deadly kinds of bacteria. Now the researchers know what it takes to block iPGM function.

Small Molecule 52

Small Molecule Science Drug Development Disease 52

The Pharma Data

DECEMBER 1, 2020

is a commercial stage oncology-focused biotech company dedicated to improving treatment and clinical outcomes for patients through therapeutic antibodies that harness the immune system to fight cancer. About Innate Pharma: Innate Pharma S.A.

Cell Biology 52

Cell Biology Clinical Trials Production Licensing 52

The Pharma Data

JANUARY 4, 2021

IPH6101/SAR443579 is a NKp46-based NK cell engager (NKCE) using Innate’s proprietary multispecific antibody format (Gauthier et al. Cell 2019 ). The companies are also currently working on the second research program. “ About NKp46-based NKCE: NKp46 is an activating receptor expressed on all NK cells.

Drugs 40

Drugs Cell Biology Pharmacokinetics Clinical Trials 40

The Pharma Data

MARCH 11, 2021

Second, the biorevolution is driving innovation in all of Bayer’s divisions – with major progress in cell biology, gene editing and data science. business and expanding its leading position in China, the Pharmaceuticals Division is focused on enhancing its innovation capabilities and continuing to develop its research pipeline. “We

Science 52

Science Pharmaceuticals Licensing Licensing 52

Codon

APRIL 9, 2023

This is Codon Digest, my weekly roundup of research, news, and industry highlights about the future of biology. The CAR-T cells were detectable in 26 out of 27 children after 30 months. Of those, 17 children responded to the treatment, and the 3-year overall survival rate was 60 percent. Nucleic Acids Research.

Therapies 52

Therapies RNA Engineering Vaccine 52

Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. ” — Samuel Butler , 1878 (* = My picks) AI + Bio Characterizing the interaction conformation between T-cell receptors and epitopes with deep learning. Nucleic Acids Research. Esyunina D.

DNA 52

DNA RNA Engineering Licensing 52