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Codon Digest: Vaccine Printer Go Brrrrr!

Codon

Also, last week’s digest had an error: The country that approved the malaria vaccine was Ghana. 🔥 Five Amazing Things (That happened this week…) 1/ CRISPR Protein Penetrates Cells Not one, but two new papers report a better way to deliver Cas9 or Cas12 gene-editing proteins into living cells. Things are good.

Vaccine 52
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Codon Digest: Vaccine Printer Go Brrrrr!

Codon

Also, last week’s digest had an error: The country that approved the malaria vaccine was Ghana. 🔥 Five Amazing Things (That happened this week…) 1/ CRISPR Protein Penetrates Cells Not one, but two new papers report a better way to deliver Cas9 or Cas12 gene-editing proteins into living cells. Things are good.

Vaccine 52
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Codon Digest: Injected Gene Editors

Codon

Read A new DNA polymerase variant, called RT-KTq I614Y, can directly detect RNA modifications, including pseudouridine (Ψ) and queuosine (Q). By combining this new variant with standard sequencing methods, it’s possible to identify RNA modifications in a really simple way. Communications Biology. Andreano E.

DNA 52
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Codon Digest: CAR-T Therapy for Neuroblastoma

Codon

Small snippets of double-stranded RNA were sprayed onto hot pepper plants to control a pest, called Frankliniella occidentalis. The RNA strands shut down a specific gene in the insects, and killed half after 7 days. RNA may offer a safer form of pest control in the future. Nature Chemical Biology. Current Biology.

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Codon Digest: GPT-4 Controls a Robot

Codon

Read RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Nature Cell Biology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. Read An RNA-based system to study hepatitis B virus replication and evaluate antivirals. Nature Biotechnology.