Codon

APRIL 30, 2023

Also, last week’s digest had an error: The country that approved the malaria vaccine was Ghana. 🔥 Five Amazing Things (That happened this week…) 1/ CRISPR Protein Penetrates Cells Not one, but two new papers report a better way to deliver Cas9 or Cas12 gene-editing proteins into living cells. Things are good.

Vaccine 52

Vaccine Engineering DNA RNA 52

Codon

APRIL 30, 2023

Also, last week’s digest had an error: The country that approved the malaria vaccine was Ghana. 🔥 Five Amazing Things (That happened this week…) 1/ CRISPR Protein Penetrates Cells Not one, but two new papers report a better way to deliver Cas9 or Cas12 gene-editing proteins into living cells. Things are good.

Vaccine 52

Vaccine Engineering DNA RNA 52

Codon

APRIL 2, 2023

Read A new DNA polymerase variant, called RT-KTq I614Y, can directly detect RNA modifications, including pseudouridine (Ψ) and queuosine (Q). By combining this new variant with standard sequencing methods, it’s possible to identify RNA modifications in a really simple way. Communications Biology. Andreano E.

DNA 52

DNA RNA Engineering Licensing 52

Codon

APRIL 9, 2023

Small snippets of double-stranded RNA were sprayed onto hot pepper plants to control a pest, called Frankliniella occidentalis. The RNA strands shut down a specific gene in the insects, and killed half after 7 days. RNA may offer a safer form of pest control in the future. Nature Chemical Biology. Current Biology.

Therapies 52

Therapies RNA Engineering Vaccine 52

Codon

APRIL 16, 2023

Compact gene editors , called enOsCas12f1 and enRhCas12f1, are smaller than many existing Cas proteins and can thus be more easily delivered in a single virus for gene therapies. By engineering the sgRNA and optimizing these proteins, new variants had high editing efficiencies and low off-target effects in human cells. Arieta C.M.

Engineering 52

Engineering DNA RNA Science 52