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The aim is to establish condensate biology as a fundamental branch of cellbiology – “cellbiology 2.0” The underlying biology and processes upon which the company was founded have broad applicability across various human disease areas. Klein notes the importance of Dewpoint’s disease-agnostic approach.
I sharpened my focus in my early teen age years when I decided I wanted to harness my interest in human biology to make medicines for people. I studied Natural Sciences at the University of Cambridge, where I was exposed to a range of disciplines from chemistry to physiology, specialising in my last year in biochemistry.
I was ‘pre-med’ and got really interested in the science and especially the integration of chemistry and art. I struggled with going to graduate school in art conservation science, ie, the science of art, or more general chemistry, and I decided to do chemistry because it had broader opportunities. Integration is really the key.
Credit: National Center for Advancing Translational Sciences, NIH When you think of the causes of infectious diseases, what first comes to mind are probably viruses and bacteria. Missing was the usual pocket-shaped active site, where a traditional smallmolecule can readily bind and block function. ” [1] Or was it?
This discovery sheds new light on the intricate mechanisms at play within cancer cells when faced with adverse conditions. When bound to GRP78, ID2 loses its inhibitory function, leading to increased invasiveness of cancer cells.
My role involved generating and characterizing complex proteins critical for biological assay development, hit discovery, and structural biology. During this time, I had the opportunity to step in as an interim Discovery Sciences project lead, sparking my interest in project leadership.
At Aduro, he was responsible for all manufacturing and supply chain activities for the company’s biologics and smallmolecules and managed a transatlantic team. in CellBiology from Utrecht University. UTRECHT, The Netherlands–( BUSINESS WIRE )– AM-Pharma B.V. , Kenilworth, N.J., Dr. van de Laar holds a M.Sc.
Basic Science *No evidence for a common blood microbiome based on a population study of 9,770 healthy humans. Read Health *Base editing rescue of spinal muscular atrophy in cells and in mice. Mice and human cells that were given the therapy had normal levels of the survival motor neuron protein, and no symptoms. Cell Systems.
But if you start to play with the times during which these genes are expressed, you can make cells age differently. Often, when we engineer a cell, we only mess with the magnitude of an effect; this study suggests that we should think more about the timing, too. Read more at Science. Nature CellBiology.
But if you start to play with the times during which these genes are expressed, you can make cells age differently. Often, when we engineer a cell, we only mess with the magnitude of an effect; this study suggests that we should think more about the timing, too. Read more at Science. Nature CellBiology.
Traditionally, drug discovery has focused on small-molecule therapeutics, typically with a molecular weight of less than 500 Daltons. 2 Typically, small-molecule drugs target active sites buried inside proteins. What are macrocycles and why are they interesting for drug discovery?
Protein nitration assays are widely used in many research areas including but not limited to biochemistry , biotechnology , cellbiology , microbiology , and molecular biology. In the highlighted study, the CLARIOstar Plus was used to detect peroxynitrite during phagocytosis with a smallmolecule sensor.
Likarda initially developed CSS to overcome the lack of effective delivery systems for cell therapies. It subsequently demonstrated promise for the administration of peptides, monoclonal antibodies and smallmolecules. Sirridge Excellence in Medicine and Science Award.
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