Drug Target Review

JULY 31, 2023

If you are collaborating with all of these different people, if you’re providing the small molecule tools for lots of different projects, how can I evaluate you as an independent scientist?” When I started in academics 16 years ago, I heard the question, “how can I evaluate your work if you are not the last author?

DNA 98

DNA Small Molecule Science Cell Biology 98

Drug Target Review

AUGUST 10, 2023

When bound to GRP78, ID2 loses its inhibitory function, leading to increased invasiveness of cancer cells. Implications for cancer therapeutics and beyond These findings have wide-ranging implications for cancer treatment and cell biology research.

Cell Biology 52

Cell Biology Small Molecule Regulations Engineering 52

Reprocell

NOVEMBER 20, 2023

CHIR99021, also known as CT99021, is a small molecule compound that has proven to be a potent and versatile tool in the world of stem cell biology and regenerative medicine. It acts as a selective inhibitor of glycogen synthase kinase 3 (GSK-3) with a high affinity for GSK-3β.

Research 52

Research Small Molecule Cell Biology 52

BMG Labtech

NOVEMBER 21, 2023

Effectors of signal transmission events Second messengers are small molecules or ions that transmit signals received at the cell surface to the inside environment of the cell (Fig.

Small Molecule 40

Small Molecule Regulations Research Cell Biology 40

The Pharma Data

OCTOBER 19, 2020

At Aduro, he was responsible for all manufacturing and supply chain activities for the company’s biologics and small molecules and managed a transatlantic team. in Cell Biology from Utrecht University. Prior to Aduro, Dr. van de Laar held various development and manufacturing positions at MSD (trademark of Merck & Co.,

Trials 40

Trials Small Molecule Cell Biology Clinical Trials 40

Elrig

APRIL 29, 2024

Fascinated by the potential of AI in medical research, I transitioned to BenevolentAI in early 2023 as a Biology Project Leader. There, I supported AI-enabled DD efforts in their small molecule portfolio. Driven by an interest in drug discovery Millie joined AstraZeneca after completion of her PhD at the end of 2020.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Codon

APRIL 2, 2023

An open-source FACS automation system for high-throughput cell biology. Cell Systems. Read Small-molecule aptamer for regulating RNA functions in mammalian cells and animals. Read The FDA is reviewing a “controversial cell therapy for ALS,” developed by BrainStorm Cell Therapeutics.

DNA 52

DNA RNA Engineering Licensing 52

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. Read Microbes in the wild ‘talk’ to their neighbors by emitting, and sensing, small chemicals. Cell Systems.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. Read Microbes in the wild ‘talk’ to their neighbors by emitting, and sensing, small chemicals. Cell Systems.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

FEBRUARY 28, 2023

I felt like a scientist for the first time, and I began to grasp the “numbers of biology” (many calculations in this essay come from that course and another textbook, Cell Biology by the Numbers.) Without mathematics, I learned, biology is naked; we can only comprehend it at arm's length.

RNA 52

RNA DNA Cell Biology Small Molecule 52

Drug Target Review

JANUARY 16, 2025

Traditionally, drug discovery has focused on small-molecule therapeutics, typically with a molecular weight of less than 500 Daltons. 2 Typically, small-molecule drugs target active sites buried inside proteins. What are macrocycles and why are they interesting for drug discovery?

Drug Development 52

Drug Development Small Molecule Drugs FDA Approval 52

BMG Labtech

FEBRUARY 24, 2025

Protein nitration assays are widely used in many research areas including but not limited to biochemistry , biotechnology , cell biology , microbiology , and molecular biology. In the highlighted study, the CLARIOstar Plus was used to detect peroxynitrite during phagocytosis with a small molecule sensor.

Small Molecule 52

Small Molecule Disease Licensing Licensing 52

Codon

APRIL 16, 2023

Nature Cell Biology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. Read Aer Therapeutics, a University of California, San Francisco lab spinout developing an inhaled small molecule drug for chronic obstructive pulmonary disease, raised $36 million in a Series A.

Engineering 52

Engineering DNA RNA Science 52

Drug Target Review

MARCH 26, 2025

Likarda initially developed CSS to overcome the lack of effective delivery systems for cell therapies. It subsequently demonstrated promise for the administration of peptides, monoclonal antibodies and small molecules. Table 2 compares the characteristics of the microbead hormones with the other administration methods.

Therapies 52

Therapies Compliance Treatment Small Molecule 52