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Drug discovery is a complex and vital field that continually seeks to identify new therapeutic targets and develop effective treatments. In recent years, a novel approach known as condensate biology has emerged, revolutionising the way researchers think about drug discovery and development.
Shortly after finishing my studies, I landed my first job in industry working on cellbiology research for several disease indications. Now we’re focusing on delivering oral smallmolecule degraders to provide a new generation of convenient, highly effective therapies for patients with immunology conditions.
They then developed a new therapeutic approach with a potent small-molecule inhibitor of this enzyme. Certain subtypes of blood cancers such as acute leukemias rely on multiple mechanisms for sustaining growth of aggressive cancer cells. Their findings are published online in Nature CellBiology.
Now, NIH researchers and their collaborators have discovered a new kind of treatment that holds promise for fighting parasitic roundworms. A bonus of this result is that this same treatment might work also for certain deadly kinds of bacteria. All of their hard work came up empty.
mRNA biology has become widely recognised as a new “drug mine” RNAi drugs are in the market and mRNA vaccines, initially developed for Covid-19, are already in trials for cancer. All of these are novel targets to be explored in smallmolecule drug discovery as well as for improving the efficacy of mRNA vaccines.
Metastasis is the most lethal attribute of cancer cells and clinical decisions regarding treatment are based largely upon the likelihood of developing metastases. 1 The research, supported by the National Institutes of Health, centres on a cellular chaperone protein called GRP78, responsible for regulating protein folding within cells.
an emerging leader focused on the treatment of kidney disease, sepsis and organ injury, today announced the appointment of Maarten Kraan, M.D., At Aduro, he was responsible for all manufacturing and supply chain activities for the company’s biologics and smallmolecules and managed a transatlantic team. 20, 2020 09:00 UTC.
Mice and human cells that were given the therapy had normal levels of the survival motor neuron protein, and no symptoms. When delivered using AAV9 in mice, the treatment significantly improved motor function and extended average lifespan. An open-source FACS automation system for high-throughput cellbiology. Wiener D.M.
Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature CellBiology. Read Microbes in the wild ‘talk’ to their neighbors by emitting, and sensing, small chemicals. Cell Systems.
Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature CellBiology. Read Microbes in the wild ‘talk’ to their neighbors by emitting, and sensing, small chemicals. Cell Systems.
Protein nitration assays are widely used in many research areas including but not limited to biochemistry , biotechnology , cellbiology , microbiology , and molecular biology. In the highlighted study, the CLARIOstar Plus was used to detect peroxynitrite during phagocytosis with a smallmolecule sensor.
Nature CellBiology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. Cell Reports. Read Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice. Nature Biotechnology. million ($1.58
Hormone replacement therapy (HRT) for low hormone levels is one of the oldest treatments utilised in Western medicine and can be traced back centuries. 2 Sex hormone replacement also gained in popularity, notably starting in 1940, when conjugated equine oestrogen was approved for the treatment of postmenopausal women. Ann Intern Med.
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