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Fighting Parasitic Infections: Promise in Cyclic Peptides

NIH Director's Blog: Drug Discovery

Researchers soon began screening a chemical library and its more than 380,000 traditional drug candidates to find the right small-molecule inhibitor, the preferred compound in drug discovery. Missing was the usual pocket-shaped active site, where a traditional small molecule can readily bind and block function.

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Codon Digest: Injected Gene Editors

Codon

Therapeutic neutralizing monoclonal antibody administration protects against lethal yellow fever virus infection. Read A really simple way to isolate AAVs, which are a type of virus often used to deliver gene therapies into cells. An open-source FACS automation system for high-throughput cell biology. Cell Systems.

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Codon Digest: Vaccine Printer Go Brrrrr!

Codon

This works for many different cell types, and the method can also be used to deliver several different gene editors at once. It’s an easier way to get CRISPR into cells! Other methods to deliver Cas9 (like with viruses) are way less efficient, and seem to vary wildly from one cell to the next. Nature Cell Biology.

Vaccine 52
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Codon Digest: Vaccine Printer Go Brrrrr!

Codon

This works for many different cell types, and the method can also be used to deliver several different gene editors at once. It’s an easier way to get CRISPR into cells! Other methods to deliver Cas9 (like with viruses) are way less efficient, and seem to vary wildly from one cell to the next. Nature Cell Biology.

Vaccine 52
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Codon Digest: GPT-4 Controls a Robot

Codon

Compact gene editors , called enOsCas12f1 and enRhCas12f1, are smaller than many existing Cas proteins and can thus be more easily delivered in a single virus for gene therapies. By engineering the sgRNA and optimizing these proteins, new variants had high editing efficiencies and low off-target effects in human cells. Cell Reports.