Drug Target Review

AUGUST 24, 2023

Neutralising GDF-15 with CatalYm’s anti-GDF-15 antibody visugromab was shown to reverse its inhibitory effects and to re-sensitise tumours to anti-PD-1 treatment, achieving commensurate survival benefit of anti-GDF-15-anti-PD-1 combination therapy in vivo. Current Opinion in Cell Biology. Biophysical Journal.

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Drug Target Review

OCTOBER 31, 2023

When I was studying cell biology, looking at how cells divide, I couldn’t fathom how math could possibly fit into that. My undergraduate studies focused on biochemistry and cell biology, so very much STEM-based, but my professors and mentors noticed my penchant for critical thinking which led me to consider law.

Cell Biology 107

Cell Biology Pharmaceuticals Science Disease 107

Drug Target Review

APRIL 9, 2024

Initial works from the lab concentrated on exploring the role of replicative stress in cancer and ageing, for which the group combined cell biology, mouse models and drug development projects. Among other discoveries, the group developed inhibitors of the ATR kinase and showed their potential for cancer therapy.

RNA 64

RNA Cell Biology Clinical Development Disease 64

Drug Target Review

JULY 23, 2024

Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. Now we’re focusing on delivering oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with immunology conditions.

Small Molecule 116

Small Molecule Targeted Protein Degradation Science Disease 116

The Pharma Data

JANUARY 3, 2021

“Both Jerry and Jeff have proven and successful track records in the design and execution of early and late-stage clinical trials that have evaluated novel immune therapies.

Immune Response 40

Immune Response Clinical Trials Therapies Cell Biology 40

The Pharma Data

JANUARY 23, 2021

On a larger scale, the tool may greatly aid existing and future TNBC studies that are currently exploring new therapies for targeted treatments. This will allow clinicians to better interpret the role of collagen remodeling in tumor progression and its prognostic value. Assessing Collagen Features at a Finer Level of Detail.

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DrugBank

JUNE 27, 2023

Their use, as well as their integration into other types of data, has enabled the development of more precise therapies. Network expansion of genetic associations defines a pleiotropy map of human cell biology. 20 When applied to a global view, inequity extends to the relative wealth of different world regions.

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The Pharma Data

OCTOBER 22, 2020

INTERLINK-1 represents first Phase 3 study examining IO approach in R/M SCCHN patients who have been treatedwith a platinum-based therapy and PD-(L)1 inhibitor. Overall, the combination therapy data to date supports the expedited development of monalizumab and cetuximab in this indication. MARSEILLE, France, Oct.

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Drug Target Review

OCTOBER 2, 2024

Cell and gene therapies (CGTs) have made significant advancements in treating oncological diseases, with therapies like CAR-T cell treatments transforming cancer care. However, cell-based therapies are intended to leverage those healthy cells via transplant to regenerate damaged tissue.

Therapies 98

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Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. The team found that deleting the gene Ptpn2 made tumors sensitive to PD-1 therapy, and they published their findings in Nature in 2017.

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Research Immune Response Clinical Trials Therapies 137

Drug Target Review

JUNE 5, 2023

There is a high unmet medical need in this area because while other candidates have shown early signs of clinical activity, there is still a need for therapies with improved safety and efficacy profiles. Mesothelin (MSLN) is overexpressed in many cancer indications, including pancreatic, mesothelioma and ovarian.

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Treatment Pharmacokinetics Drugs Cell Biology 100

Drug Target Review

JUNE 29, 2023

I think the cell-therapy field has evolved a lot – and is continuing to do so – in the time I’ve been working with this. Regarding the NY-ESO programme that we worked on, I started work on that in 2002 before we even knew that we were going to do cell therapy.

Therapies 115

Therapies Science Production Cell Biology 115

Codon

APRIL 9, 2024

With help from the Global Fund to Fight AIDS, Tuberculosis, and Malaria (GFATM), artemisinin-based combination therapy became much more economically accessible worldwide. When Louis Miller, now Chief of Malaria Cell Biology at the NIH, attended a malaria conference in Shanghai in 2008, he asked: Who discovered artemisinin?

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The Pharma Data

MARCH 16, 2022

The research scientist at the Max Planck Institute for Medical Research received the award in recognition of his ground-breaking work in establishing various approaches to protein labeling in living cells that have enabled far-reaching advances in chemical and cell biology. Protein labeling (e.g.

Cell Biology 52

Cell Biology Molecular Biology Science Research 52

PerkinElmer

JANUARY 21, 2022

1 To address the urgent need for new therapies, the UK’s Medical Research Council (MRC), a national public agency supporting health science and research, established the Dementias Platform United Kingdom (DPUK) in 2014. “Our Of these, around 850,000 live in the United Kingdom (UK) at an annual care cost of £26 billion (US$38 billion).

Cell Biology 52

Cell Biology Disease Treatment Science 52

Codon

APRIL 9, 2023

“Computer science is to biology what calculus is to physics.” ” — Harold Morowitz 🔥 Ten Amazing Things (that happened this week…) A CAR-T therapy was tested in 27 children with neuroblastomas. The CAR-T cells were detectable in 26 out of 27 children after 30 months. Molecular Therapy.

Therapies 52

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The Pharma Data

MARCH 11, 2021

Second, the biorevolution is driving innovation in all of Bayer’s divisions – with major progress in cell biology, gene editing and data science. One example is the acquisition of Asklepios BioPharmaceutical (AskBio), a leading company in the field of gene therapy. annually, with the division set to gain further market share.

Science 52

Science Pharmaceuticals Licensing Licensing 52

Codon

APRIL 2, 2023

Read Health *Base editing rescue of spinal muscular atrophy in cells and in mice. Read A one-time gene therapy injection for spinal muscular atrophy. Mice and human cells that were given the therapy had normal levels of the survival motor neuron protein, and no symptoms. Gene Therapy. Trends in Biotechnology.

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DNA RNA Engineering Licensing 52

Precision for Medicine

APRIL 7, 2023

These labs are an integral part of the transformational infrastructure of capabilities Precision has built to accelerate the development of complex therapies.”

Laboratories 52

Laboratories Clinical Research Clinical Trials Cell Biology 52

Codon

APRIL 30, 2023

5/ Lots O’ Gene Therapies Not one, but two applications for sickle-cell gene therapies have been submitted to the F.D.A. If approved, these wouldn’t be the first gene therapies on the market, but they would be the first gene therapies for a disease that affects something like 100,000 Americans.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

5/ Lots O’ Gene Therapies Not one, but two applications for sickle-cell gene therapies have been submitted to the F.D.A. If approved, these wouldn’t be the first gene therapies on the market, but they would be the first gene therapies for a disease that affects something like 100,000 Americans.

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Vaccine DNA Engineering RNA 52

The Pharma Data

MARCH 15, 2022

. “The problem is that cells only make small amounts of p53 and then quickly break it down as it is a very large and disordered protein,” says the study’s last author Michael Landreh, researcher at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet.

Cell Biology 52

Cell Biology Research DNA Vaccine 52

BMG Labtech

MARCH 8, 2023

In biology , scientific research on cell metabolism focuses on different topics such as understanding the fundamental metabolic processes, metabolic changes and their role in diseases (including cancer cell and tumor metabolism), the development of therapies, the identification of unknown metabolic processes and metabolites, etc.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

SEPTEMBER 22, 2024

They achieved this by treating mouse fetal ovaries with an enzyme mixture to break them apart into single cells, isolating the ovarian supporting cells, and mixing them with human PGC-like cells to form aggregates, which were then cultured in liquid media for up to 120 days.

DNA 117

DNA Laboratories Regulations Therapies 117

Drug Target Review

APRIL 1, 2025

Advances in biotechnology are driving significant progress in the treatment of rare diseases, making it possible to develop targeted therapies for previously untreatable conditions. Founded in 2021, SynaptixBio is working to develop therapies for TUBB4A leukodystrophies – a group of rare and severe neurological disorders.

Disease 52

Disease Therapies Clinical Trials Cell Biology 52

Codon

APRIL 16, 2023

Compact gene editors , called enOsCas12f1 and enRhCas12f1, are smaller than many existing Cas proteins and can thus be more easily delivered in a single virus for gene therapies. By engineering the sgRNA and optimizing these proteins, new variants had high editing efficiencies and low off-target effects in human cells. Occelli L.M.

Engineering 52

Engineering DNA RNA Science 52

Drug Target Review

MARCH 26, 2025

Hormone replacement therapy (HRT) for low hormone levels is one of the oldest treatments utilised in Western medicine and can be traced back centuries. 6 Both testosterone and oestrogen are also used for gender-affirming therapy. Likarda initially developed CSS to overcome the lack of effective delivery systems for cell therapies.

Therapies 52

Therapies Compliance Treatment Small Molecule 52

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

Broad Institute

NOVEMBER 21, 2024

Bernstein is also chair of the Department of Cancer Biology at Dana-Farber Cancer Institute, a professor in cell biology and pathology at Harvard Medical School, and holds the Richard and Nancy Lubin Family Chair. Inevitable progression Gliomas arise from glial cells, which protect and support a healthy nervous system.

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Research Medical Schools DNA Hospitals 124

SugarCone Biotech

MAY 28, 2019

Learnings regarding immune geography and cell:cell contact are increasingly important as we consider how best to advance cell therapies for diverse hematologic malignancies and solid tumors ( www.aletabio.com ). Aren’t we just waking up exhausted T cells, or moving T cells from the tumor margin into the tumor bed?

Immune Response 52

Immune Response Therapies Engineering Drug Development 52

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

NOVEMBER 1, 2024

Molecular biology has only been around for about 80 years, and tools to study biomolecules (such as DNA and RNA sequencing, or proteomics) have only existed for about half of that time. We are in the absolute infancy of molecular and cell biology, and this means there’s a lot of stuff we still don’t understand.

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