Drug Target Review

JULY 13, 2023

Drug discovery is a complex and vital field that continually seeks to identify new therapeutic targets and develop effective treatments. In recent years, a novel approach known as condensate biology has emerged, revolutionising the way researchers think about drug discovery and development.

Disease 98

Disease Small Molecule Cell Biology Drugs 98

KIF1A

MARCH 2, 2024

Read the Article Rare Roundup The Jackson Laboratory offers “Exploring Rare Disease Through Translational Research” MiniCourse Human health is incredibly complex; developing safe, effective treatments requires knowledge of molecular mechanisms, cell biology, and drug administration.

Laboratories 119

Laboratories Cell Biology Disease Research 119

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. When I began my PhD I completely switched my focus, and I haven’t looked back,” said Manguso.

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Research Immune Response Clinical Trials Therapies 137

Drug Target Review

NOVEMBER 24, 2023

Promise of new diagnostics and treatment New approaches may be found for diagnosing and treating a range of brain disorders, such as schizophrenia , by creating a connectome of the human brain. The hippocampus , positioned in the temporal lobe, is phylogenetically one of the oldest parts of the brain and forms part of the limbic system.

Cell Biology 105

Cell Biology Engineering Research Treatment 105

Drug Target Review

AUGUST 24, 2023

We will explore how GDF-15 impacts the tumour microenvironment and hinders the infiltration of T cells into the tumour, as well as the implications of neutralising GDF-15 to reverse its inhibitory effects and sensitise tumours to anti-PD-1 treatment. T-cell infiltration is a prerequisite for responses to checkpoint inhibitors.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

Drug Target Review

APRIL 12, 2024

By isolating single cells prior to transfection and injecting RNP directly into the nucleus, research scientists can achieve high transfection efficiencies in hard-to-transfect cells — helping to bring CRISPR treatments to patients faster. 2023) ‘The Ins and Outs of Single Cell Gene Editing’, New Matter. 1] Rosen, H.

Cell Biology 105

Cell Biology FDA Approval FDA Research 105

Drug Target Review

JANUARY 30, 2024

Adenylyl cyclase superactivation induced by long-term treatment with opioid agonist is dependent on receptor localized within lipid rafts and is independent of receptor internalization. Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons. Br J Pharmacol. 2012;165(6):1704-16. Mol Pharmacol.

Treatment 52

Treatment Doctors Cell Biology Regulations 52

Drug Target Review

APRIL 12, 2024

By isolating single cells prior to transfection and injecting RNP directly into the nucleus, research scientists can achieve high transfection efficiencies in hard-to-transfect cells — helping to bring CRISPR treatments to patients faster. 2023) ‘The Ins and Outs of Single Cell Gene Editing’, New Matter. 2 Rosen, H.

Cell Biology 98

Cell Biology FDA Approval FDA Research 98

Drug Target Review

OCTOBER 2, 2024

Cell and gene therapies (CGTs) have made significant advancements in treating oncological diseases, with therapies like CAR-T cell treatments transforming cancer care. By correcting these mutations, gene-modifying and editing therapies hold the promise of long-term, potentially curative treatments.

Therapies 98

Therapies Disease Engineering RNA 98

Drug Target Review

JUNE 7, 2024

The proof for this came with the approval of KIMMTRAK (tebentafusp-tebn) by the FDA in 2022 for the treatment of HLA-A*02:01+ metastatic or unresectable uveal melanoma, a historically “cold” tumour known to be resistant to current available checkpoint immunotherapies.

Engineering 81

Engineering Clinical Trials Therapies Cell Biology 81

Drug Target Review

OCTOBER 31, 2023

When I was studying cell biology, looking at how cells divide, I couldn’t fathom how math could possibly fit into that. My undergraduate studies focused on biochemistry and cell biology, so very much STEM-based, but my professors and mentors noticed my penchant for critical thinking which led me to consider law.

Cell Biology 107

Cell Biology Pharmaceuticals Science Disease 107

PerkinElmer

JANUARY 21, 2022

DPUK became the world’s largest collaborative research organization focused on early detection, better treatment, and prevention of neurodegenerative conditions. By identifying these biomarkers, we can get a handle on the mechanisms of the disease that will lead to new treatments,” he said.

Cell Biology 52

Cell Biology Disease Treatment Science 52

The Pharma Data

SEPTEMBER 21, 2020

The funding will be used to develop a pipeline of ‘highly selective’ gene therapies targeting cancer stem cells in a variety of solid tumour types. It will draw on research led by Professor Steven Pollard at the University of Edinburgh, which delved into stem cell biology, synthetic biology and cancer genomics.

Therapies 52

Therapies Cell Biology Licensing Licensing 52

Drug Target Review

AUGUST 10, 2023

Metastasis is the most lethal attribute of cancer cells and clinical decisions regarding treatment are based largely upon the likelihood of developing metastases. 1 The research, supported by the National Institutes of Health, centres on a cellular chaperone protein called GRP78, responsible for regulating protein folding within cells.

Cell Biology 52

Cell Biology Small Molecule Regulations Engineering 52

Broad Institute

FEBRUARY 29, 2024

He hopes to model and investigate drug responses in diseased neuronal systems, ultimately aiming to improve mental health treatments that have stalled in recent decades. During this time, he gained significant single-cell biology training through co-mentorship by Aviv Regev at the Klarman Cell Observatory.

Cell Biology 52

Cell Biology Disease Science Treatment 52

KIF1A

MAY 24, 2023

The approach often focuses the patient-voice around a common goal of treatment, be it to inform a clinical endpoint or identify patient demographics for a drug treatment. Integrating patient perspectives is a necessary step in our collective goal of finding rare disease treatments and cures. elegans neurons”.

Disease 98

Disease Laboratories Research Science 98

Drug Target Review

JULY 23, 2024

Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. While we’ve had many great accomplishments, the best is still ahead as we work to transform treatment paradigms.

Small Molecule 116

Small Molecule Targeted Protein Degradation Science Disease 116

Drug Target Review

DECEMBER 21, 2023

That creates a resource for scientists, including data science researchers who want to apply machine learning to cell images; now they have more than 200,000 cells they can play with. It also allows scientists to explore hypotheses about the cell biology of undifferentiated stem cells.

International 105

International Science Disease Research 105

The Pharma Data

FEBRUARY 24, 2022

Their findings are published online in Nature Cell Biology. “We are amazed by the efficiency of small-molecule PROTAC in simultaneously targeting EZH2 and cMyc in cancer cells.” MS177 achieves on-target effect in cancer cells and exhibits profound tumor killing effects, the researchers report.

Small Molecule 52

Small Molecule Cell Biology Research Drug Development 52

Drug Target Review

JUNE 29, 2023

Obviously there are lots of issues to work on, but it’s a real modality that is changing people’s lives for the long term and changing the way we think about cancer treatments. When it comes down to cell biology itself, cells can do so many different things.

Therapies 115

Therapies Science Production Cell Biology 115

The Pharma Data

MARCH 15, 2022

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. By adding a spider silk protein to p53, they show that it is possible to create a protein that is more stable and capable of killing cancer cells.

Cell Biology 52

Cell Biology DNA Research Vaccine 52

The Pharma Data

JANUARY 23, 2021

On a larger scale, the tool may greatly aid existing and future TNBC studies that are currently exploring new therapies for targeted treatments. TNBC is an incredibly challenging and aggressive form of breast cancer compared to other subtypes and holds a relatively poor prognosis primarily due to a lack of targeted treatments.

Treatment 52

Treatment Cell Biology Hospitals Clinical Trials 52

Precision for Medicine

APRIL 7, 2023

The custom-designed laboratory accommodates the growth in demand for advanced digital pathology and imaging capabilities, expertise in molecular sciences and a wide array of sequencing technologies.

Laboratories 52

Laboratories Clinical Research Clinical Trials Cell Biology 52

The Pharma Data

MARCH 25, 2022

The findings, which are described in the journals Nature Communications and Science Advances, could pave the way for new treatments against COVID-19.

Molecular Biology 52

Molecular Biology Laboratories Cell Biology Science 52

The Pharma Data

DECEMBER 1, 2020

is a commercial stage oncology-focused biotech company dedicated to improving treatment and clinical outcomes for patients through therapeutic antibodies that harness the immune system to fight cancer. About Innate Pharma: Innate Pharma S.A.

Cell Biology 52

Cell Biology Clinical Trials Production Licensing 52

The Pharma Data

OCTOBER 19, 2020

an emerging leader focused on the treatment of kidney disease, sepsis and organ injury, today announced the appointment of Maarten Kraan, M.D., in Cell Biology from Utrecht University. We are a dedicated team driven to bring treatment options to severely ill patients, their families and acute care professionals.

Trials 40

Trials Small Molecule Cell Biology Clinical Trials 40

DrugBank

JUNE 27, 2023

The general notion is that patients should be viewed individually, rather than strictly as members of some larger general population, and that their specific genetic background, environment, and lifestyle choices should be considered throughout drug development to the point of treatment and continuing patient care.

Disease 87

Disease Treatment Drugs Clinical Trials 87

The Pharma Data

NOVEMBER 17, 2021

Now, new research led by investigators at Harvard Medical School and Boston Children’s Hospital points to a well-known and widely available drug called disulfiram as a possible treatment for COVID-19. The drug is FDA-approved and has been prescribed for over 60 years as a treatment for alcoholism. ” Sander recalled.

Virus 52

Virus Drugs Clinical Trials Medical Schools 52

Drug Target Review

DECEMBER 21, 2023

There must be something different in those diseased cells, some dysregulated pathway that is causing that disease phenotype. And since mRNA biology is like the highway of cell biology, it would likely be visible there. This has the power to us discover treatments for so many diseases.

Disease 105

Disease Small Molecule Vaccine Drugs 105

The Pharma Data

DECEMBER 31, 2020

Adult brains undergo similar treatment, but it’s not well understood why adult synapses are eliminated. When brains develop, they constantly grow new neuronal connections—synapses—as they learn and remember. Important connects are nurtured and reinforced while seemingly unnecessary ones are pruned.

Research 52

Research Virus Immune Response Cell Biology 52

The Pharma Data

JANUARY 3, 2021

It is my privilege to advise NexImmune as it seeks to develop novel treatments for melanoma and other cancers,” stated Dr. Weber. The AIM technology enables NexImmune to construct nanoparticles that function as synthetic dendritic cells capable of directing a specific T cell-mediated immune response.

Immune Response 40

Immune Response Clinical Trials Therapies Cell Biology 40

Drug Target Review

MAY 22, 2023

That creates a resource for scientists, including data science researchers who want to apply machine learning to cell images; now they have more than 200,000 cells they can play with. It also allows scientists to explore hypotheses about the cell biology of undifferentiated stem cells. Any other comments?

International 59

International Science Disease Research 59

NIH Director's Blog: Drug Discovery

APRIL 11, 2017

Now, NIH researchers and their collaborators have discovered a new kind of treatment that holds promise for fighting parasitic roundworms. A bonus of this result is that this same treatment might work also for certain deadly kinds of bacteria.

Small Molecule 52

Small Molecule Science Drug Development Disease 52

The Pharma Data

JANUARY 4, 2021

Such trifunctional NKCEs have proven more effective in pre-clinical models than classical antibodies directed against the same tumor target, as co-engagement of multiple surface receptors on NK cells is required for their full activation. About NKp46-based NKCE: NKp46 is an activating receptor expressed on all NK cells.

Drugs 40

Drugs Cell Biology Pharmacokinetics Clinical Trials 40

The Pharma Data

MARCH 11, 2021

Second, the biorevolution is driving innovation in all of Bayer’s divisions – with major progress in cell biology, gene editing and data science. And third, the company is accelerating its transformation and further increasing efficiency.

Science 52

Science Pharmaceuticals Licensing Licensing 52

The Pharma Data

OCTOBER 22, 2020

The steady and rapid progress of this program is a testament to our strong collaboration with AstraZeneca, and we are hopeful that together we will bring a novel treatment option to this patient population with high unmet medical need.”. The activity of cetuximab as a single agent in recurrent and/or metastatic SCCHN is limited, with a 12.6%

Clinical Trials 40

Clinical Trials Trials Cell Biology Production 40

Codon

OCTOBER 22, 2024

This is a strong indication that peer reviewers push back against the aforementioned signs of importance hacking — namely, inflated importance and a weak treatment of limitations. Interestingly, the study found that peer review most improved the author’s discussions of their work’s limitations and implications.

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Science Research Government Cell Biology 107