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Early evidence and emerging trends: How AI is shaping drug discovery and clinical development

Drug Target Review

These approaches may also have important implications in the development of novel drugs to treat a range of eye diseases, including glaucoma. Traditional drugs for eye diseases like glaucoma are small molecules delivered by simple eye drops. With these complexities comes a need to increase the probability of clinical success.

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Denali Therapeutics and Biogen Announce Initiation of Phase 2b Study of LRRK2 Inhibitor in Parkinson’s Disease

The Pharma Data

We look forward to continuing our collaboration with Biogen and the Parkinson’s community in our unified goal to develop BIIB122 as a potential treatment option for people and families living with Parkinson’s disease.”. BIIB122 is an investigational small molecule inhibitor of LRRK2 that was discovered and developed by Denali.

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Build Generative AI Pipelines for Drug Discovery with NVIDIA BioNeMo Service

Nvidia Developer: Drug Discovery

New supercomputing-scale large language models (LLMs) that understand biology and chemistry text are helping scientists understand proteins, small molecules, DNA, and biomedical text. These state-of-the-art AI models help generate de novo proteins and molecules and predict the 3D structures of proteins.

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Codon Digest: Bacteria Resist Every Virus

Codon

🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. Biological Engineering Generation of functional oocytes from male mice in vitro. Marine biofilm engineered to produce current in response to small molecules. Metabolic Engineering. Metabolic Engineering.

Virus 52
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BioSpace Movers & Shakers, Dec. 18

The Pharma Data

Kurtz brings more than 26 years of experience in global manufacturing, engineering, supply chain, CMC development and program management for drugs and devices at various stages of development. Cadavid will be responsible for the strategy, direction and execution of the company’s clinical development programs.

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New targeted therapies show promise in lung cancer treatment

Drug Target Review

7,8 The discovery of these biomarkers provides valuable insights into prognosis and disease progression, while also guiding the clinical development of new targeted immunotherapies. Engineering sites on the antibody to enable specific and consistent attachment of the cytotoxic drug to achieve an optimal drug-to-antibody ratio (DAR).

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Biopharma Money on the Move: October 21-27

The Pharma Data

Sirnaomics is the only biopharma conducting R&D and clinical development in the field of RNAi therapeutics in both the U.S. Be Bio plans to use their $52 million Series A to precisely engineer B cells to treat a range of diseases. The bladder cancer therapy is expected to be in the clinic by 2022.