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Macrophage cell therapy: a new hope for chronic liver disease patients

Drug Target Review

What are the main challenges currently faced in the treatment of chronic liver diseases, and how does Resolution Therapeutics aim to address these challenges? Once a patient develops advanced cirrhosis/end-stage liver disease there are no specific therapies to significantly avoid major decompensations and death in the next few years.

Therapies 114
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SRP-001: redefining pain treatment with a safer, non-opioid analgesic

Drug Target Review

As a non-opioid, SRP-001 also eliminates abuse potential, positioning it as a safer and effective drug candidate for the treatment of acute and neuropathic pain and migraine headache. How does SRP-001’s safety profile, especially concerning hepatotoxicity and nephrotoxicity, compare to other common pain medications?

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T-cell receptors offer window to the cell for a new class of cancer therapeutics

Drug Target Review

Monoclonal antibodies (mAbs) targeting tumour-specific antigens play an essential role in the treatment of many cancers. 3 Conclusion Human evolution has developed an elegant system that allows HLA presentation to open a ‘window into the cell’ and enable very precise immune monitoring of cellular health and disease states.

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Women in Stem with Dr Amber D. Van Laar

Drug Target Review

Nevertheless, the potential to pioneer and move the needle for patients with few treatment options drives me to push through. During my training, I saw US medical school admissions reach parity. Harnessing the non-clinical and clinical experience with gene therapy, she then joined Brain Neurotherapy Bio, Inc.

Therapies 111
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Targeting the immunotherapy potential of cytokines IL-12 and IL-18 with new advancements in protein engineering

Drug Target Review

In this IO arena, we continue to search for additional treatments that can further benefit patients. Immune checkpoint inhibitors, a well-established class of IO treatments, are designed to improve the ability of T-cells to fight cancer by removing inhibitory or suppressive mechanisms that may dampen the anti-cancer functions of T cells.

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UK launch for Novo's new diabetes pill

The Pharma Data

. Novo Nordisk has launched in the UK the first ‘protein in a pill’ treatment for type II diabetes. Despite a number of treatments on the market, 40% of adults with the disease in the UK fail to achieve target blood sugar of ?

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Tiziana Life Sciences plc announces completion of the clinical trial with nasally administered Foralumab, its proprietary fully human anti-CD3 monoclonal antibody, for the treatment of COVID-19 patients in Brazil

The Pharma Data

Anecdotal feedback from Foralumab-treated patients was positive and suggests that the treatment was well-tolerated. The scientific approaches underlying this clinical study could potentially be effective against SARs, MERS, and all variants of coronaviruses. NEW YORK and LONDON, Jan.