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Metabolism of macrocyclic drugs

Metabolite Tales Blog

With metabolic stability in mind, we take a look at the metabolism of some FDA approved synthetic macrocyclic drugs, and a few of those that were/are in clinical development where metabolism data was available. Journal of Medicinal Chemistry 62 (21), 9418-9437. Balazs et al., Drug Hunter article, June 2023.

Drugs 52
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Metabolism of de novo designed macrocyclic drugs

Metabolite Tales Blog

With metabolic stability in mind, we take a look at the metabolism of some FDA approved synthetic macrocyclic drugs, and a few of those that were/are in clinical development where metabolism data was available. Journal of Medicinal Chemistry 62 (21), 9418-9437. Balazs et al., Drug Hunter article, June 2023.