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Re-assessing the risks of drug-induced arrhythmias during drug discovery

Drug Discovery World

We propose the evaluation of new electrophysiological recording and analysis techniques, using intact beating hearts and based on the fractionation analysis of paced electrocardiograms, to see if they have a higher degree of predictive validity in determining the risk of pharmacologically induced arrythmias in humans. 12(3): 197-202.

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