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Yet, the absence of established systemic and brain pharmacokinetic (PK) parameters at relevant pre-clinical doses presents a significant knowledge gap. In vitro assays examined brain tissue binding and metabolicstability. It further emphasizes the importance of selecting pharmacologically relevant pre-clinical doses.
Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. It was hypothesized that as glecaprevir is largely metabolized by the liver, the production of toxic or immunogenic metabolites was a possible source of injury [7].
Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. It was hypothesized that as glecaprevir is largely metabolized by the liver, the production of toxic or immunogenic metabolites was a possible source of injury [7].
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