Metabolism of macrocyclic drugs
Metabolite Tales Blog
JULY 5, 2023
Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. Journal of Medicinal Chemistry 62 (21), 9418-9437. link] [4] Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry. link] [9] PHARMACOLOGY/TOXICOLOGY NDA REVIEW AND EVALUATION.
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