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These treatments use a vector to introduce the desired nucleic acid code to replace or modify proteinexpression or use cells to alter/restore a specific cell type. Cell and gene therapies (CGTs) are one of the fastest growing areas in human therapeutics.
Molecular factors Molecular markers, such as proteinexpression and signalling pathway activation, also guide therapy choices. For example, PD-L1 expression predicts the response to immune checkpoint inhibitors. This approach underlies the identification of the OBD, backed by both clinical efficacy and drug tolerability data.
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