Advarra
JANUARY 11, 2024
The applications of mRNA-based therapies in cancer research represent one of the next groundbreaking steps toward improved cancer treatments. While mRNA usage has played several roles in clinical research , oncology researchers in particular are eager to explore the possibilities of mRNA-based cancer vaccines.
PPD
OCTOBER 12, 2023
These treatments use a vector to introduce the desired nucleic acid code to replace or modify protein expression or use cells to alter/restore a specific cell type. Cell and gene therapies (CGTs) are one of the fastest growing areas in human therapeutics.
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Conversations in Drug Development Trends
MAY 30, 2024
Other researchers are investigating approaches that use AAV-mediated trophic support and antibody-based therapies, such as vaccines and small molecule drugs, to modify various protein expressions. As we continue to explore current treatments and venture into new avenues of research, there lies hope for those affected by ALS.
Broad Institute
AUGUST 24, 2022
The team then conducted analyses that triangulated treatment response, chromosomal deletion or gain, and concordant decreases or increases in mRNA and protein expression. Of the hundreds of genes deleted in this location, the DNA ligase gene LIG1 was one of the mostly consistently suppressed genes at both the mRNA and protein level.
The Pharma Data
SEPTEMBER 8, 2020
The findings are expected to improve current understanding of MS disease biology and treatment response, among African-American and Hispanic- and Latinx-American patients with MS, with the ultimate goal of increasing high-quality standard of care to traditionally underserved communities and enhancing equality through clinical research.
The Anticancer Fund
SEPTEMBER 29, 2021
Itraconazole Exerts its Anti-Tumor Effect in Esophageal Cancer by Suppressing the HER2/AKT Signaling Pathway Published in Molecular Cancer Therapeutics Using in vitro , in vivo and human data from a clinical trial (NCT02749513) - the authors show that itraconazole targets the HER2-AKT axis, in esophageal cancer.
Conversations in Drug Development Trends
APRIL 7, 2025
Solid tumors present a significant challenge to clinical research due to their complex and heterogeneous nature. Proactively Address Key Recruitment Challenges in Solid Tumor Clinical Research Solid tumor clinical research is challenging, especially because of tumor heterogeneity.
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