Drug Target Review

FEBRUARY 21, 2024

Stem cell transplants have saved patients’ lives time and time again, which led us to launch our own Stem Cell Transplant and Cellular Therapy Program. Regarding CAR-T cell therapy, could you highlight the promising findings that have been identified in the early stages of drug discovery, as well as potential challenges?

Therapies 64

Therapies Treatment FDA Approval Vaccine 64

Vial

MARCH 6, 2024

The field of clinical research is a dynamic and rapidly evolving one. One way to ensure that you are at the forefront of these developments is by attending clinical research conferences. AACR, founded in 1907, is the world’s oldest and largest professional organization dedicated to advancing cancer research.

Clinical Research 52

Clinical Research Research Clinical Trials Trials 52

Drug Discovery World

DECEMBER 13, 2022

Clinical research organisation (CRO) Emmes has unveiled a dedicated centre to expand its cell and gene therapy research. . The new centre will offer research services in clinical trial operations, study leadership, statistical services, data management, and pharmacovigilance. .

Therapies 130

Therapies Clinical Trials Clinical Research Trials 130

Advarra

JUNE 27, 2023

A clinical trial investigating a drug or therapy is typically divided into four phases: Phase I, Phase II, Phase III, and Phase IV. Each phase has a different purpose in testing the treatment’s safety and efficacy. Currently incurable diseases would remain so, without any improvements made to existing drugs and therapies.

Clinical Research 52

Clinical Research Research Clinical Trials Trials 52

Drug Discovery World

AUGUST 11, 2023

GenScript Biotech and T-MAXIMUM Biotech have formed a strategic collaboration to develop T-MAXIMUM’s CAR-T cell therapy using GenScript’s CRISPR nucleic acid reagents. T-MAXIMUM Biotech hopes to progress multiple products to the Phase II clinical research stage and deliver products to market within the next five years. .”

Therapies 130

Therapies Clinical Research Production FDA 130

Olympian Clinical Research

MAY 6, 2024

The journey toward effective treatments has been long and evolving, with recent breakthroughs offering new hope to those living with this challenging condition. From Coal Tar to Biologics: A Historical Perspective The history of psoriasis treatment is as old as the condition itself, with records dating back to ancient times.

Treatment 52

Treatment Small Molecule Immune Response Clinical Research 52

Drug Discovery World

DECEMBER 8, 2023

Andrew Busey , Co-Founder, Form Bio discusses why vertical AI is set to reshape the cell and gene therapy sector. The cell and gene therapy industry is no exception to this digital transformation. It is imperative for the industry to communicate the precise composition and attributes of these therapies to regulatory bodies.

Therapies 163

Therapies Clinical Trials Small Molecule Production 163

Drug Target Review

JUNE 9, 2023

This exclusive interview with Dr Sharon Benzeno, Chief Commercial Officer, Immune Medicine at Adaptive Biotechnologies, unveils some ground-breaking research on T- cell therapy for cancer , which has seen the first TCR-based therapeutic candidate progress to clinical development, offering promising advancements in innovative cancer treatments.

Treatment 105

Treatment Packaging Clinical Research Therapies 105

Drug Target Review

SEPTEMBER 22, 2023

Organoid technologies are becoming an invaluable solution for preclinical research, with the ability to augment the development of personalised medicine, drug discovery and gene therapies. Organoids for cell therapy and drug discovery. Stem cell-derived organoids and their application for medical research and patient treatment.

Clinical Research 116

Clinical Research Research Drug Development Molecular Biology 116

Olympian Clinical Research

NOVEMBER 30, 2023

Vitiligo, characterized by the loss of skin pigment and the formation of white patches, has been a subject of medical intrigue and research for decades. The Evolution of Vitiligo Treatments From ancient remedies to modern medicine, the treatment of vitiligo has undergone a remarkable transformation.

Treatment 52

Treatment Clinical Research Clinical Trials Immune Response 52

Olympian Clinical Research

FEBRUARY 22, 2024

However, advancements in treatments and ongoing clinical research offer new hope. The complexity of HS means that treatment is often multifaceted, aiming not only to manage symptoms but also to address the underlying causes of inflammation. Surgery: In severe cases, surgical removal of affected skin may be necessary.

Treatment 52

Treatment Clinical Research Clinical Trials Therapies 52

Vial

DECEMBER 4, 2023

Clinical research is an integral component of the healthcare ecosystem. It is pivotal in the development of cutting-edge treatments, therapies, and interventions for a wide array of diseases. Patient Payments in Clinical Research: Perception Over the Years In the U.S.,

Clinical Research 52

Clinical Research Research Clinical Trials Regulations 52

Vial

MAY 20, 2024

Distinguishing the Roles of Preclinical vs. Clinical CROs in Clinical Research Randomized clinical trials are the gold-standard of evidence-based medicine, representing the culmination of the long, arduous drug development pipeline.

Clinical Research 52

Clinical Research Research Clinical Trials Laboratories 52

LifeSciVC

JULY 17, 2024

Reaching the end goal of delivering transformational new treatment options for patients can take a decade or more even when companies execute successfully and are well capitalized. We already have the first-ever clinical-stage NBD1 stabilizer and a second series of highly potent NBD1 stabilizers that are advancing to Phase 1 this summer.

Clinical Research 45

Clinical Research Disease Research Clinical Trials 45

PPD

JUNE 27, 2024

In general, ongoing research in AA is focused on molecules whose mechanism of actions and effectiveness have been proven in psoriasis and atopic dermatitis. CorEvitas will be deploying AA focus groups among physicians and patients to provide insights for pragmatic clinical trial designs. Accelerate your alopecia areata treatments.

Treatment 52

Treatment Clinical Trials Small Molecule Clinical Research 52

Advarra

SEPTEMBER 14, 2023

In the clinical research space, GxP is a set of quality regulations and guidelines designed to establish the safety, efficacy, and integrity of pharmaceuticals, medical devices, and clinical trials. This blog explores key concepts, regulations, and the importance of GxP in delivering successful clinical trials.

Clinical Research 52

Clinical Research Research Compliance Clinical Trials 52

Drug Discovery World

JUNE 25, 2024

Phesi created a digital twin for chronic graft versus host disease (cGvHD) in the primary treatment setting. The digital twin was developed to replicate patients receiving prednisone, the first-line treatment currently used as the standard-of-care for cGvHD, and commonly used in control arms of prospective clinical trials.

Clinical Trials 148

Clinical Trials Trials Hospitals Clinical Research 148

Drug Discovery World

JULY 2, 2024

City of Hope, US, researchers are now in discussions with the global SWOG Cancer Research Network to design a Phase II/III trial to assess the novel use of CBM588 and microbiome modulation in people with advanced cancer. Scientists from Osel and Miyarisan Pharmaceutical, the manufacturer of CBM588, collaborated on the study.

Trials 148

Trials Treatment Clinical Trials Licensing 148

Olympian Clinical Research

NOVEMBER 9, 2022

Therefore, if you or a loved one is dealing with this rare condition, it’s essential to educate yourself about the condition and its potential treatments. Radiation therapy. The disease sometimes goes into remission, only to return later — this is especially common once treatment is stopped.

Treatment 52

Treatment Clinical Research Immune Response Therapies 52

Olympian Clinical Research

MARCH 6, 2024

Managing rosacea can be challenging, but with the right treatments, many people see significant improvements. Here’s a closer look at the top treatments that can help control this condition and why professional guidance is key. What’s effective for one person might not be for another, making personalized treatment plans essential.

Treatment 52

Treatment Therapies Production 52

Vial

DECEMBER 8, 2023

With technological innovation and scientific research propelling the development of new therapies, anticipation for the future is high. The goal of this therapy is to replace a disease-causing gene with a healthy one, disable a disease-causing gene, or introduce a new gene to aid in fighting a disease.

Therapies 52

Therapies Clinical Trials Trials Treatment 52

Advarra

JANUARY 11, 2024

The applications of mRNA-based therapies in cancer research represent one of the next groundbreaking steps toward improved cancer treatments. While mRNA usage has played several roles in clinical research , oncology researchers in particular are eager to explore the possibilities of mRNA-based cancer vaccines.

Vaccine 52

Vaccine Therapies Clinical Trials Small Molecule 52

National Drug & Alcohol Research Centre Blog

JULY 13, 2021

NCCRED was funded through the Strategy, and commenced in 2018, to build clinical research capacity and work towards establishing evidence-based treatment approaches for both methamphetamines and other emerging drugs of concern. Why do a clinical research priority setting study?

Clinical Research 52

Clinical Research Research Clinical Trials Trials 52

Olympian Clinical Research

NOVEMBER 16, 2022

More research is still needed to understand the causes of HS fully. Receiving an accurate and prompt diagnosis of HS is essential for developing a treatment plan and preventing it from worsening. Treatments for Hidradenitis Suppurativa. There are also a number of different treatments in developmental stages currently. .

Treatment 52

Treatment Clinical Research Immune Response Research 52

Drug Discovery World

MAY 29, 2024

All 11 trial participants had experienced disease progression in prior immunotherapy treatment before joining the trial. These preliminary findings represent some of the initial positive evidence emerging from the burgeoning field of clinical research on cancer therapies leveraging gut microbiota.

Trials 130

Trials Clinical Trials Treatment Clinical Development 130

Drug Discovery World

APRIL 25, 2023

University of California researchers have dosed the second participant in their clinical trial to identify a potential cure for HIV utilising CAR-T cell therapy. The trial is the first-in-human clinical study investigating the duo CAR-T cell therapy for the treatment of HIV. “We

Research 130

Research Clinical Trials Therapies Clinical Development 130

Drug Discovery World

APRIL 17, 2024

The Bios Innovation Circle is aimed at empowering the success of biotech and life science companies, investors, pharmaceutical companies, clinical research organisations and other innovative solution providers to accelerate development and bring life-saving treatments to the market faster.

Science 130

Science Pharmaceutical Companies Clinical Research Therapies 130

Conversations in Drug Development Trends

NOVEMBER 27, 2023

Casgevy, the commercial product formerly known as exa-cel, is administered by taking stem cells out of a patient’s bone marrow and editing a gene in the cells in a laboratory, with the modified cells then infused back into the patient after conditioning treatment to prepare the bone marrow.

Treatment 75

Treatment FDA Clinical Trials Therapies 75

Olympian Clinical Research

APRIL 17, 2024

Join us as we dive into the important aspects of skin cancer, including symptoms, prevention strategies, and the latest treatment options, giving you the tools you need to enjoy the sun safely. Non-surgical Options Treatments such as topical medications, cryotherapy, and photodynamic therapy are effective for less advanced skin cancers.

Treatment 52

Treatment Therapies 52

Drug Target Review

JULY 12, 2023

Molecular-level biochemical assays like transcriptomics, genomics and proteomics have emerged as valuable tools for identifying potential targets in cancer treatment through deep cyclic inhibition (DCI). How does the DCI mechanism compare to the design of other drugs for cancer treatment?

Biochemical Assays 98

Biochemical Assays Treatment Bioinformatics Disease 98

Drug Discovery World

AUGUST 11, 2023

The US Food and Drug Administration (FDA) has approved Izervay (avacincaptad pegol intravitreal solution) for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Slowing of disease progression was observed as early as six months with up to a 35% reduction in the first year of treatment.

FDA Approval 130

FDA Approval FDA Clinical Trials Clinical Research 130

Drug Discovery World

AUGUST 18, 2023

Thermo Fisher Scientific has completed its acquisition of CorEvitas, a provider of real-world evidence for approved medical treatments and therapies, for $912.5 We are very excited to welcome our new CorEvitas colleagues to Thermo Fisher,” said Marc Casper, Chairman, President and Chief Executive Officer of Thermo Fisher.

Laboratories 130

Laboratories Clinical Research Therapies Regulations 130

Drug Discovery World

AUGUST 18, 2023

My chosen news stories this week all discuss pre-clinical research studies that could have a huge impact on our therapeutic approach to several hard-to-treat diseases, helping to overcome drug-resistance and make treatments more targeted in the future. News round-up for 14-18 August by DDW Digital Content Editor Diana Spencer.

Small Molecule 130

Small Molecule Virus Drugs Clinical Research 130

Drug Discovery World

MARCH 10, 2023

Perhaps most interestingly this week, after previous caution over in vivo gene therapy trials, the FDA has given the go ahead to Intellia Therapeutics to study NTLA-2002 in hereditary angioedema (HAE).

Clinical Trials 130

Clinical Trials Small Molecule Trials Drugs 130

Drug Discovery World

MARCH 23, 2023

iOnctura, a clinical stage biotechnology company developing cancer therapies, has published non-clinical research on roginolisib in the AACR journal Cancer Research Communications. The research also highlights roginolisib has immune-modulatory properties that can be exploited in solid tumours.

Research 246

Research Clinical Research Treatment Therapies 246

Drug Discovery World

SEPTEMBER 23, 2022

An interesting week for clinical research and drug approvals, with rare diseases being a key focus for both the FDA and European Commission. The last week has seen data emerge on how Omicron infection could protect against influenza, how breast cancer cells evade therapies, and two approvals on rare diseases in the US and EU.

FDA Approval 130

FDA Approval FDA Drugs Therapies 130

Conversations in Drug Development Trends

JUNE 21, 2024

The 2024 ASCO Annual Meeting from the American Society of Clinical Oncology is a fantastic platform for clinical researchers to discuss the latest advancements and challenges in oncology research.

Clinical Trials 64

Clinical Trials Clinical Research Immune Response Therapies 64