Drug Discovery World

JANUARY 17, 2023

Genoscience Pharma, a clinical-stage biotech company developing lysosomotropic drug candidates for the treatment of cancer, fibrosis and auto-immune diseases through autophagy modulation has launched the ABE-LIVER study, along with trial sponsor Grenoble University Hospital. . The trial . Context .

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Drug Discovery World

SEPTEMBER 1, 2023

Accurate dose prediction for clinical trials is essential to ensure patient safety and trial success. This new whitepaper from the Jackson Laboratory discusses evidence-based selection of starting doses in first-in-human clinical trials through the utilisation of humanised mouse models.

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Drug Discovery World

OCTOBER 20, 2023

A new free service will offer insights in under ten days to sponsors conducting clinical trials, identifying potential ‘zombie trials’ and providing actionable recommendations for failing trials. The Health Check and Trial Rescue Service is an initiative of data software and services company Phesi.

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Drug Discovery World

JULY 17, 2023

Analysis of 13,490 clinical trials finds almost a third have been cancelled during Phase II amidst an overall decline in clinical development productivity. Data analytics company Phesi has released the results of its mid-year global analysis of all clinical trials conducted in 2023 to date.

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Drug Discovery World

APRIL 14, 2023

By Lucy Radley , Senior Vice President, Head of European Regulatory Development at ProPharma Group. Clinical trials are, undoubtedly, an essential part of the drug development process, providing us with valuable information about the safety and efficacy of new treatments and therapies.

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Drug Discovery World

JANUARY 26, 2024

Dr Bentwich will present on ‘ How artificial intelligence and patient-on-a-chip are improving drug development ’ on Tuesday 6 February at 3pm. His presentation will explore the impact of Quris-AI’s Bio-AI platform in the field of drug development.

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Drug Discovery World

JULY 26, 2022

This is the latest episode of the free DDW podcast, “Now is the time for the transformation of clinical trials”. They are called “Clinical trials, the pandemic and technology” and “Pharma and the benefits of Real World Data ”. . It covers two narrated articles written for Volume 22, Issue 4 – Fall 2021 of DDW.

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Drug Discovery World

AUGUST 9, 2023

The UK Medicines and Healthcare products Regulatory Agency (MHRA) has granted Aleta Biotherapeutics a clinical trial authorisation (CTA) to evaluate biologic ALETA-001 in a Phase I/II clinical trial in patients with B-cell malignancies who are relapsed/refractory to CD19 CAR T cell therapy.

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Conversations in Drug Development Trends

MAY 10, 2024

Over the past two decades, industry-sponsored clinical trials have targeted treatments for BPD, yielding some promising outcomes; however, broader psychiatric research often excludes BPD patients, a trend that extends to the emerging field of psychedelic studies.

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Drug Discovery World

AUGUST 1, 2024

Download the whitepaper to learn more about: The importance of selecting appropriate starting doses in clinical trials. Download the whitepaper to learn more about: The importance of selecting appropriate starting doses in clinical trials. The post How can you ensure a confident transition to human trials?

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Drug Discovery World

OCTOBER 14, 2022

Cambridge Cognition has entered into an agreement to acquire eClinicalHealth Ltd (eCH), a full-service digital technology provider that is working on virtual clinical trials for three of the world’s top ten largest pharmaceutical companies. . The virtual clinical trial market . References .

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Drug Discovery World

AUGUST 1, 2024

This paper discusses the challenges drug developers face when transitioning from preclinical discovery to clinical trials and proposes expanding the drug development toolbox with humanised mouse models. Why humanised mice better predict human responses to therapeutics.

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Conversations in Drug Development Trends

AUGUST 29, 2024

By: Nathan Chadwick, Therapeutic Strategy Lead, Rare Disease Over the last few years in clinical trials, particularly within the rare disease community, a notable shift is underway, where patients and caregivers are taking the lead in reaching out to clinical trial sites rather than the other way around.

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Drug Discovery World

JULY 26, 2022

This is the latest episode of the free DDW podcast, “Now is the time for the transformation of clinical trials”. They are called “Clinical trials, the pandemic and technology” and “Pharma and the benefits of Real World Data ”. . It covers two narrated articles written for Volume 22, Issue 4 – Fall 2021 of DDW.

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PPD

JULY 6, 2023

It’s estimated that nearly three out of every four clinical trials are conducted by contract research organizations (CROs), highlighting just how much sponsors value — and rely on — the work that CROs perform. Surveys show that CROs improve trial efficiency and increase productivity.

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Quanticate

AUGUST 2, 2024

Real-world evidence (RWE) is changing clinical drug development, bridging the gap between controlled clinical trial environments and the complexities of everyday patient experiences.

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PPD

AUGUST 14, 2024

Clinical trials have significantly increased in complexity over the last 20 years, creating new challenges. One of the top reported challenges facing drug developers today is recruiting, enrolling and retaining the right patients for studies. The increase in complexity isn’t just creating challenges for patients.

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Drug Discovery World

SEPTEMBER 12, 2022

Chaired by Karin Blumer, Director of Global Patient Engagement at Novartis, the first event in this track, called ‘Patient Engagement: Driving Patient Advocacy to Inform Patient Centric Development’, looked into the multi-layered importance of involving patients in the drug development process, particularly in this case for gene therapy.

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Conversations in Drug Development Trends

MARCH 20, 2024

In the increasingly advancing world of medicine, personalized care is a key factor that can progress your drug development efforts. One way to ensure customized disease management is to utilize pharmacogenomics (PGx) in your clinical trial.

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Vial

MAY 13, 2024

Introduction The biopharma industry is poised to make revolutionary advances in and redefine drug development, and the current climate for innovation appears ideal. only 5% of molecules in oncology Phase I trials reach the market taking, on average, 7.5 An estimated 80% of clinical trials do not finish on time.

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Drug Discovery World

OCTOBER 3, 2023

In pharmaceutical development, collaborating with multiple Contract Development and Manufacturing Organisations (CDMOs) and Contract Research Organisations (CROs) poses potential hurdles – from poor communication to delays, errors, and inconsistent feedback during the progression from preclinical to formulation optimisation and clinical trials.

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Antidote

JUNE 20, 2024

Though collecting accurate data, keeping precise records, and measuring results are all complex tasks involved with medical research, clinical trial recruitment and enrollment are often cited as the most challenging part of the process. By some estimates, delays in drug development can cost study sponsors roughly $37,000 a day.

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Conversations in Drug Development Trends

JULY 8, 2024

By: Lisle Kingery, PhD, Therapeutic Strategy Lead, Neuroscience With depression rates at an all-time high and limited new treatments available, depression clinical trials are more important than ever. Treatment Treatment can take various forms, including therapy, medication, a combination of both, or a clinical trial.

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PPD

DECEMBER 19, 2022

PPD, Thermo Fisher Scientific ’s clinical research business, surveyed more than 150 decision-making leaders at pharmaceutical and biotech companies around the globe to collect key insights on the state of the evolving drug development industry. The opportunity to leverage new technologies in drug development (e.g.,

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Vial

MARCH 25, 2024

Introduction Worldwide Clinical Trials vs. Vial. Worldwide Clinical Trials is a mid-size, full-service global contract research organization (CRO) that works with biotech and pharma to advance new medications. How do they stack up? Other therapeutic areas include cell and gene therapy.

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Drug Discovery World

OCTOBER 3, 2023

In pharmaceutical development, collaborating with multiple Contract Development and Manufacturing Organisations (CDMOs) and Contract Research Organisations (CROs) poses potential hurdles – from poor communication to delays, errors, and inconsistent feedback during the progression from preclinical to formulation optimisation and clinical trials.

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Vial

FEBRUARY 29, 2024

Contract research organizations (CROs) are an integral partner of the drug development process, as they play a pivotal role supporting clinical trial conduct for pharmaceutical, biotechnology, and medical device sponsor companies. That is, how many clinical trials are actually managed by these organizations?

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Alta Sciences

NOVEMBER 9, 2023

Streamlining Clinical Trial Start-up for Accelerated Drug Development mecabana Thu, 11/09/2023 - 16:54 Publication StreamliningClinicalTrialStart-up-ReducedTimelines.pdf Category Case Study Weight 5

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H1 Blog

DECEMBER 4, 2023

As the pharmaceutical and biotech industries continue to push for faster drug development, the importance of equity and diversity in clinical trial recruitment cannot be overlooked. Let’s dive in to uncover the role of digital health and data in driving faster drug development through improved diversity.

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PPD

MARCH 21, 2024

When participating in clinical trials, pediatric populations require distinct considerations for their safety and well-being — which can present unique challenges for drug developers. Five Strategies to Tailor Your Pediatric Clinical Trials to the Child’s Needs 1.

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PPD

DECEMBER 7, 2023

The Sustainable Healthcare Coalition , a not-for-profit, health care sector-led group based in the United Kingdom, concluded that globally, clinical research could generate the equivalent of 100 million tons of carbon dioxide (CO2) emissions each year. These results can then be used to enhance the accuracy of the predictive model.

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Conversations in Drug Development Trends

FEBRUARY 26, 2024

With the necessary prioritization of various factors when designing your clinical trial, the patient experience can be overlooked or improperly addressed in study design. However, incorporating the patient experience into your design is one of the best ways to ensure your drug development program is a commercial success.

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PPD

DECEMBER 7, 2023

The Sustainable Healthcare Coalition , a not-for-profit, health care sector-led group based in the United Kingdom, concluded that globally, clinical research could generate the equivalent of 100 million tons of carbon dioxide (CO2) emissions each year. These results can then be used to enhance the accuracy of the predictive model.

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PPD

MAY 18, 2023

Yet, four out of five care partners of people with neurodegenerative disorders have never been informed of clinical trial opportunities , according to a survey of more than 250 caregivers conducted by PPD, the clinical research business of Thermo Fisher Scientific. There’s little time to lose.

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Drug Discovery World

SEPTEMBER 8, 2022

Cytel has expanded its operations into the Asia-Pacific region (APAC), with hopes of optimising clinical trial design in the area. New norms set during the COVID-19 pandemic have only fueled the industry’s expectations of accelerated drug development,” said James Matcham, Executive Strategic Consultant, Cytel, Australia. .

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Drug Discovery World

DECEMBER 6, 2022

As a result of clear US Food and Drug Administration (FDA) guidelines, the leading vaccine development programmes for Covid-19 were all remarkably similar. Indeed, few randomised trials of NPIs have been undertaken. Quasi-experimental and other randomised trial designs . Pre-specification of effect size .

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Fierce BioTech

MARCH 6, 2024

Pediatric Clinical Trials: Considerations for Enrollment and Retention In this insightful paper we explore regulatory guidelines implemented to encourage pediatric drug development, specific study considerations particularly concerning safety and regulatory aspects (e.g.,

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