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Patent Highlights: Allosteric AR Modulators, Glycogen Synthase Inhibitors, and More

Drug Hunter

Maze’s Oral GYS1 Inhibitor, MZE001 Sanofi is paying $150 million plus up to $600 million in milestones for Maze Therapeutics’ glycogen synthase 1 (GYS1) program, including MZE001, which aims to reduce glycogen substrate build-up in Pompe disease.

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Lead Pharma enters into a Research Collaboration and License Agreement with Roche to Develop Oral Small Molecules for Immune Mediated Diseases

The Pharma Data

” “We are committed to advancing innovative science and transformative medicines for people affected by different immune mediated diseases”, says James Sabry , Global Head, Roche Pharma Partnering. ” About Immune Mediated Diseases. A wide range of human diseases is driven by deregulated immune function.

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Drug Repurposing: A New Life for Old Drugs

DrugBank

Opportunities in Drug Repurposing There is great potential for drug repurposing to unlock treatments for rare and neglected diseases, where traditional drug development is too costly. Pharma companies are often rich with valuable chemical libraries and expertise, while academics bring emerging disease biology knowledge.

Drugs 98
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Here's a nice Christmas gift - ChEMBL 35 is out!

The ChEMBL-og

AI-driven Structure-enabled Antiviral Platform (ASAP) (src_id = 71): The AI-driven Structure-enabled Antiviral Platform (ASAP, asapdiscovery.org), funded by National Institute of Allergy and Infectious Diseases is dedicated to the development of novel chemical assets that have antiviral activity against viral families with future pandemic potential.

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Sygnature Discovery and Daewoong Pharma announce research collaboration

Sygnature Discovery

Sygnature Discovery is pleased to have entered into a research collaboration agreement with the global healthcare group Daewoong Pharmaceutical to accelerate the discovery of a novel small molecule to target autoimmune disease.

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The Data-Driven Future of Drug Development

DrugBank

Computational chemistry and molecular modeling techniques can predict potential drug candidates' binding affinity and pharmacokinetic properties, enabling the selection of the most promising compounds for further development.

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Some Thoughts on Biotech vs Pharma for Computational Chemists

Practical Cheminformatics

A recent editorial by Dean Brown in J Med Chem and follow-up posts by Keith Hornberger and Derek Lowe prompted me to think about how we train computational chemists and cheminformaticians for careers in drug discovery. It also brought to mind some unique differences between how computational chemistry is practiced in biotech and pharma.