Sygnature Discovery

MARCH 14, 2025

An extra 11,000 were internally produced using similar principles, with further compounds actively synthesised and added to the library annually. Collaboration with customers and Sygnatures computational chemists ensures quality hit identification using computational chemistry triage, counter screens, and orthogonal assays.

Biochemical Assays 52

Biochemical Assays Fragment Screening Computational Chemistry Assay Development 52

Sygnature Discovery

MARCH 24, 2022

Sygnature’s first logo Led by founder Simon Hirst, this ambitious small Chemistry group hit the ground running, quickly developing strong relationships with customers and expanding into other scientific specialities like Computational Chemistry.

Computational Chemistry 52

Computational Chemistry International Science Pharmaceuticals 52

Drug Target Review

SEPTEMBER 20, 2023

From 2005 to 2008 he carried out a DPhil (PhD) at Oxford on nanomaterials for quantum computation, followed by postdoctoral work on the prediction of crystal structures at University College London. Matthew subsequently put his computational chemistry skills to use in the defence sector.

Drugs 105

Drugs Metabolic Stability Computational Chemistry Pharmaceuticals 105

LifeSciVC

APRIL 27, 2023

The premise at the time was that putting computational chemistry in the primary position for new molecule ideation would upend the drug discovery paradigm. set up a “virtual project team,” leverage Schrödinger scientists to lead computational chemistry, and do all the wet work at CROs. It did just that.

Small Molecule 40

Small Molecule Computational Chemistry Engineering Clinical Development 40

Molecular Design

AUGUST 2, 2020

Fragment-based lead discovery (FBLD) actually has origins in both crystallography [ V1992 | A1996 ] and computational chemistry [ M1991 | B1992 | E1994 ]. Measurement of affinity is important in fragment-to-lead work because it allows fragment-based structure-activity relationships to be established prior to structural elaboration.

Fragment Screening 40

Fragment Screening Computational Chemistry Engineering Drugs 40