Drug Target Review

NOVEMBER 1, 2023

Could you provide an overview of your research on target directed cancer drug discovery, particularly your focus on protein lagging interactions. I work in the Centre for Cancer Drug Discovery (CCDD) at The Institute of Cancer Research in London, which is an academic drug discovery centre. Acta Cryst. Acta Cryst. 2013) 56, 2059-2073.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

DrugBank

OCTOBER 17, 2024

Computational chemistry and molecular modeling techniques can predict potential drug candidates' binding affinity and pharmacokinetic properties, enabling the selection of the most promising compounds for further development.

Drug Development 98

Drug Development Metabolic Stability Clinical Trials Drugs 98

Practical Cheminformatics

DECEMBER 7, 2023

A recent editorial by Dean Brown in J Med Chem and follow-up posts by Keith Hornberger and Derek Lowe prompted me to think about how we train computational chemists and cheminformaticians for careers in drug discovery. It also brought to mind some unique differences between how computational chemistry is practiced in biotech and pharma.

Computational Chemistry 87

Computational Chemistry Pharmacokinetics Drugs Pharmaceutical Companies 87

Drug Target Review

SEPTEMBER 20, 2023

From 2005 to 2008 he carried out a DPhil (PhD) at Oxford on nanomaterials for quantum computation, followed by postdoctoral work on the prediction of crystal structures at University College London. Matthew subsequently put his computational chemistry skills to use in the defence sector. References Austin D, Hayford T.

Drugs 105

Drugs Metabolic Stability Computational Chemistry Pharmaceuticals 105

Sygnature Discovery

MARCH 24, 2022

Sygnature’s first logo Led by founder Simon Hirst, this ambitious small Chemistry group hit the ground running, quickly developing strong relationships with customers and expanding into other scientific specialities like Computational Chemistry.

Computational Chemistry 52

Computational Chemistry International Science Pharmaceuticals 52

Sygnature Discovery

JULY 31, 2023

Leading integrated drug discovery partner, Sygnature Discovery (“Sygnature”) has announced its acquisition of one of North America’s largest discovery Contract Research Organisations, Canada-based NuChem Sciences. Previous acquisitions made were Peak Proteins in April 2022 and SB Drug Discovery in January 2023.

Computational Chemistry 52

Computational Chemistry Science Clinical Trials Pharmaceutical Companies 52

Dark Matter Blog

AUGUST 31, 2020

However, since most small molecule drugs target proteins in the cell, the vast majority of target identification methods available to research scientists are aimed at identifying interactions between small molecules and proteins. Our expedition gains altitude After that initial result, it was all hands on deck.

RNA 52

RNA Small Molecule Bioinformatics Computational Chemistry 52

Drug Target Review

MAY 31, 2024

Could you share an example of a specific project or research that you have worked on and the impact it has had in your field? How has your research in STEM contributed to advancements or improvements in your field, and what potential future applications or implications do you foresee based on your work?

Organic Chemistry 45

Organic Chemistry Computational Chemistry Small Molecule Disease 45

Nvidia Developer: Drug Discovery

JUNE 24, 2022

These advances, driven by developments in highly parallelizable GPUs and GPU-enabled algorithms, are bringing new possibilities to computational chemistry and structural biology for the development of novel medicines. Generative models, by implicitly learning the rules of chemistry, produce molecules that they’ve never seen before.

Drugs 52

Drugs Computational Chemistry FDA Approval Research 52