Definition FDA Approval Screening Hits 
Molecular Design
OCTOBER 14, 2018
An 'unofficial' definition for the term PAINS has actually been published and I think that it's pretty good: "PAINS, or pan-assay interference compounds, are compounds that have been observed to show activity in multiple types of assays by interfering with the assay readout rather than through specific compound/target interactions."
Practical Cheminformatics
AUGUST 3, 2023
It is quite a bit more potent than the values one finds with screening hits, which typically have IC50s in the single to double-digit µM range. Clear Definitions of Training, Validation, and Test Set Splits When building a machine learning model, it’s important to divide the data into training, (sometimes) validation, and test sets.
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