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AI in Drug Discovery - A Highly Opinionated Literature Review (Part II)

Practical Cheminformatics

Aside from some very brief demos on code generation and literature searches, mentions of LLM applications in preclinical research were scarce. pBRICS: A Novel Fragmentation Method for Explainable PropertyPredictionof Drug-Like Small Molecules [link] Perspective: I can’t say I saw a lot of progress in explainable AI for molecules this year.

Drugs 139
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Codon Digest: Discovering Antibiotics with Deep Learning

Codon

Read Programming inactive RNA-binding small molecules into bioactive degraders. The demos are this Sunday, June 4th! Molecular Therapy. Read Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies. Nature Communications. ACS Synthetic Biology. eClinicalMedicine. Tech Crunch.

DNA 52
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Codon Digest: Discovering Antibiotics with Deep Learning

Codon

Read Programming inactive RNA-binding small molecules into bioactive degraders. The demos are this Sunday, June 4th! Molecular Therapy. Read Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies. Nature Communications. ACS Synthetic Biology. eClinicalMedicine. Tech Crunch.

DNA 52