Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. A live demo is available online, but “it chews through OpenAI credits,” Patel says.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. A live demo is available online, but “it chews through OpenAI credits,” Patel says.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

MAY 22, 2023

. 🧪 From the Lab Other wet-lab papers worth checking out. (* = Recommended) *A temperature-sensitive genome-editing tool — which uses Cas9 — enhances adoptive T-cell therapy upon mild heating. Nature Nanotechnology. Read *A feedback system controls the relative populations of microbes in a community. Nature Communications.

DNA 58

DNA Engineering Science Trials 58

Codon

MAY 22, 2023

. 🧪 From the Lab Other wet-lab papers worth checking out. (* = Recommended) *A temperature-sensitive genome-editing tool — which uses Cas9 — enhances adoptive T-cell therapy upon mild heating. Nature Nanotechnology. Read *A feedback system controls the relative populations of microbes in a community. Nature Communications.

DNA 52

DNA Engineering Science Trials 52

Codon

MAY 30, 2023

This means that IscB base editors might be easier to package inside of AAVs, which can only store 4,700 bases of DNA for gene therapies. Read *An engineered influenza virus to deliver antigens for lung cancer vaccination. Molecular Therapy. Read Novartis bought a blood stem cell gene therapy program for $87.5 Tech Crunch.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

This means that IscB base editors might be easier to package inside of AAVs, which can only store 4,700 bases of DNA for gene therapies. Read *An engineered influenza virus to deliver antigens for lung cancer vaccination. Molecular Therapy. Read Novartis bought a blood stem cell gene therapy program for $87.5 Tech Crunch.

DNA 52

DNA RNA Engineering Vaccine 52