Disease - Drug Discovery Digest

Parkinson's Disease: New theory on the disease's origins and spread

Science Daily: Pharmacology News

APRIL 11, 2024

New hypothesis paper builds on a growing scientific consensus that Parkinson's disease route to the brain starts in either the nose or the gut and proposes that environmental toxicants are the likely source.

Disease

Gene editing extends lifespan in mouse model of prion disease

Broad Institute

JANUARY 14, 2025

By Allessandra DiCorato January 14, 2025 Credit: Maria Nemchuk, Broad Communications Eric Minikel and Sonia Vallabh run a lab with a singular focus: preventing and treating prion disease within their lifetime. Its a huge privilege to have the opportunity to point these powerful new tools at our disease.

Disease

Disease DNA Protein Production Treatment

Researchers devise new way to target and correct disease-related proteins

Broad Institute

JANUARY 6, 2025

Related groups Xavier lab Over the past two decades, large genetic studies have linked tens of thousands of DNA variants to thousands of human traits and diseases. Yet, correcting the effects of those variants to treat disease has been hampered in part by the lack of precise molecular tools to do so.

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Disease Research DNA Small Molecule

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Sweat health monitor measures levels of disease markers

Science Daily: Pharmacology News

JUNE 20, 2024

The 3D-printed monitor could someday provide a simple and non-invasive way to track health conditions and diagnose common diseases, such as diabetes, gout, kidney disease or heart disease. A wearable health monitor can reliably measure levels of important biochemicals in sweat during physical exercise.

Disease

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

Navigating the AI Landscape 🤖 Explore the opportunities and challenges with integrating AI in healthcare and disease prevention. From Research to Real-World Care 🌎 Understand how AI-driven advancements are shaping personalized treatments and patient outcomes. Register today to save your seat!

Clinical Trials

New Evidence Links Microplastics with Chronic Disease

Science Daily: Pharmacology News

MARCH 25, 2025

Higher exposure to these microplastics, which can be inadvertently consumed or inhaled, is associated with a heightened prevalence of chronic noncommunicable diseases, according to new research. Tiny fragments of plastic have become ubiquitous in our environment and our bodies.

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Disease Research

Alcohol raises heart disease risk, particularly among women

Science Daily: Pharmacology News

MARCH 28, 2024

Young to middle-aged women who reported drinking eight or more alcoholic beverages per week--more than one per day, on average--were significantly more likely to develop coronary heart disease compared with those who drank less, finds a study presented at the American College of Cardiology's Annual Scientific Session.

Disease

Healthy eating in midlife linked to overall healthy aging

Science Daily: Pharmacology News

MARCH 24, 2025

The study is among the first to examine multiple dietary patterns in midlife in relation to overall healthy aging.

Disease

Moderate coffee and caffeine consumption is associated with lower risk of developing multiple cardiometabolic diseases, new study finds

Science Daily: Pharmacology News

SEPTEMBER 17, 2024

Consuming moderate amounts of coffee and caffeine regularly may offer a protective effect against developing multiple cardiometabolic diseases, including type 2 diabetes, coronary heart disease and stroke, according to new research.

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Disease Research

Physical activity reduces stress-related brain activity to lower cardiovascular disease risk

Science Daily: Pharmacology News

APRIL 15, 2024

Over a ten-year period, biobank participants who met recommended levels of physical activity had a 23% lower risk of cardiovascular disease, and the protective effects were even more pronounced in individuals with depression.

Disease

Population shifts, risk factors may triple U.S. cardiovascular disease costs by 2050

Science Daily: Pharmacology News

JUNE 4, 2024

Driven by an older, more diverse population, along with a significant increase in risk factors including high blood pressure and obesity, total costs related to cardiovascular disease (CVD) conditions are likely to triple by 2050, according to recent projections. At least 6 in 10 U.S. trillion price tag in direct and indirect costs.

Disease

Taming Parkinson's disease with intelligent brain pacemakers

Science Daily: Pharmacology News

AUGUST 19, 2024

Two new studies are pointing the way toward round-the-clock personalized care for people with Parkinson's disease through an implanted device that can treat movement problems during the day and insomnia at night.

Disease

Loneliness linked to higher risk of heart disease and stroke and susceptibility to infection

Science Daily: Pharmacology News

JANUARY 3, 2025

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests. Researchers drew this conclusion after studying proteins from blood samples taken from over 42,000 adults recruited to the UK Biobank.

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Some diabetes drugs tied to lower risk of dementia, Parkinson's disease

Science Daily: Pharmacology News

SEPTEMBER 18, 2024

A class of drugs for diabetes may be associated with a lower risk of dementia and Parkinson's disease, according to a new study.

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A new approach to detecting Alzheimer's disease

Science Daily: Pharmacology News

FEBRUARY 3, 2025

Research has revealed clear evidence that changes in the orchestration of brain oxygenation dynamics and neuronal function in Alzheimer's disease contribute to the neurodegeneration.

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Disease Research

Xenon gas could protect against Alzheimer's disease: Mouse study

Science Daily: Pharmacology News

JANUARY 15, 2025

Most treatments being pursued today to protect against Alzheimer's disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research points to a novel -- and noble -- approach: using Xenon gas. A phase 1 clinical trial of the treatment in healthy volunteers will begin in early 2025.

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Human 'domainome' reveals root cause of heritable disease

Science Daily: Pharmacology News

JANUARY 8, 2025

Unstable proteins are the main drivers of many different heritable diseases, according to a new study, including genetic disorders responsible for the formation of cataracts, and different types of rare neurological, developmental and muscle-wasting diseases.

Disease

Popular diabetes and weight-loss drug may reduce risk of Alzheimer's disease

Science Daily: Pharmacology News

OCTOBER 24, 2024

Researchers have found that semaglutide may lower the risk of Alzheimer's disease in people with type 2 diabetes (T2D).

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Ozempic Could Curb Progression of Diabetes-Linked Liver Disease

Drugs.com

SEPTEMBER 16, 2024

16, 2024 -- Fatty liver disease linked to diabetes and obesity can easily progress to liver cirrhosis, but new research suggests that GLP-1 medicines like Ozempic can help stop that. MONDAY, Sept. In a new decades-long study, veterans with diabetes.

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'Weekend warrior' physical activity may help protect against more than 200 diseases

Science Daily: Pharmacology News

SEPTEMBER 26, 2024

The findings indicate that concentrated physical activity patterns may be just as effective for disease prevention as patterns where exercise is spread out throughout the week.

Disease

Gum Disease Germs Could Help Trigger Cancer

Drugs.com

SEPTEMBER 26, 2024

26, 2024 -- Bacteria that causes gum disease can also raise a person’s risk of head and neck cancers, a new study says.More than a dozen bacterial species have been linked to a collective 50% increased risk of head and neck cancer, r. THURSDAY, Sept.

Disease

AI Helps Spot Liver Disease Early

Drugs.com

NOVEMBER 18, 2024

18, 2024 -- AI can help doctors diagnose early cases of fatty liver disease, a new study says.An AI program trained to spot a leading type of the disease, called metabolic-associated steatotic liver disease (MASLD), unearthed hundreds. MONDAY, Nov.

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Gum Disease & Diabetes: A Strong Link

Drugs.com

NOVEMBER 14, 2024

14, 2024 -- Periodontal (gum) disease and diabetes are locked in a grim partnership aimed at undermining your health, experts warn.“Recent THURSDAY, Nov. Recent research has shown that diabetes is not only a major risk factor for periodontitis but that t.

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Novel bone marrow transplant can cure sickle cell disease, study suggests

Science Daily: Pharmacology News

FEBRUARY 25, 2025

A bone marrow transplant process is safe and curative for adults with sickle cell disease, according to results of a trial completed at about 20 cancer centers.

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Disease Trials

Doctors could soon use facial temperature for early diagnosis of metabolic diseases

Science Daily: Pharmacology News

JULY 2, 2024

With further research, doctors could one day use this simple and non-invasive approach for early detection of diseases. These temperature differences are not easily perceptible by one's own touch but can instead be identified using specific AI-derived spatial temperature patterns that require a thermal camera and a data-trained model.

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Microrobot-packed pill shows promise for treating inflammatory bowel disease in mice

Science Daily: Pharmacology News

JUNE 26, 2024

Engineers have developed a pill that releases microscopic robots, or microrobots, into the colon to treat inflammatory bowel disease (IBD). The experimental treatment, given orally, has shown success in mice. It significantly reduced IBD symptoms and promoted the healing of damaged colon tissue without causing toxic side effects.

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Disease Engineering Treatment

Biological organ ages predict disease risk decades in advance

Science Daily: Pharmacology News

FEBRUARY 25, 2025

Our organs age at different rates, and a blood test determining how much they've each aged could predict the risk of conditions like lung cancer and heart disease decades later, finds a new study.

Disease

Spinal cord stimulation restores neural function, targets key feature of progressive neurodegenerative disease

Science Daily: Pharmacology News

FEBRUARY 5, 2025

Boosting communication between the spinal nerves and the muscles using the spinal cord stimulation reverses spinal muscle atrophy (SMA) progression and could be applied to other motoneuron diseases, including ALS.

Disease

Low-level traffic air pollution linked to liver damage and fatty liver disease

Science Daily: Pharmacology News

JANUARY 31, 2025

Low levels of traffic-related air pollution harms the liver and may raise the risk of metabolic-associated fatty liver disease, a new study in mice suggests.

Disease

Once Again, Tuberculosis Becomes World's Top Infectious Disease Killer

Drugs.com

OCTOBER 30, 2024

30, 2024 -- In the highest tally ever recorded for tuberculosis cases, the World Health Organization reported Tuesday that over 8 million people worldwide were diagnosed with the lung disease last year.Of WEDNESDAY, Oct. that number, 1.25

Disease

Ozempic Curbs Kidney Disease in Obese People Without Diabetes

Drugs.com

OCTOBER 28, 2024

28, 2024 -- The weight-loss drug Ozempic can guard against kidney disease in obese people, a new study shows.Patients taking semaglutide -- the active agent in Ozempic and Wegovy -- had as much as a 52% reduction in kidney damage, as. MONDAY, Oct.

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Disease Drugs

Ignore antifungal resistance in fungal disease at your peril, warn top scientists

Science Daily: Pharmacology News

SEPTEMBER 12, 2024

Without immediate action, humanity will potentially face further escalation in resistance in fungal disease, a group of scientists from the around the world has warned. According to the scientists most fungal pathogens identified by the World Health Organization -- accounting for around 3.8

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Disease Drugs

All in the eyes: High resolution retinal maps aid disease diagnoses

Science Daily: Pharmacology News

FEBRUARY 4, 2025

Researchers have conducted one of the largest eye studies in the world to reveal new insights into retinal thickness, highlighting its potential in the early detection of diseases like type 2 diabetes, dementia and multiple sclerosis.

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Disease Research

Ozempic Lowers Odds for Death, Illness in People With Kidney Disease and Type 2 Diabetes

Drugs.com

MAY 24, 2024

FRIDAY, May 24, 2024 -- Ozempic provides a wide variety of health benefits for people with kidney disease and type 2 diabetes, a major clinical trial has found. The drug significantly reduces the risk of severe kidney events, heart problems and.

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Mapping 1.6 million gut cells to find new ways treat disease

Science Daily: Pharmacology News

NOVEMBER 20, 2024

By combining 25 datasets, researchers have created the largest cohesive cell atlas of the human gut and uncovered a new way that stomach cells may play a role in Inflammatory Bowel Disease.

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Disease Research

Restricting sugar consumption in utero and in early childhood significantly reduces risk of midlife chronic disease

Science Daily: Pharmacology News

OCTOBER 31, 2024

Biobank, a database of medical histories and genetic, lifestyle and other disease risk factors, to study the effect of those early-life sugar restrictions on health outcomes of adults conceived in the U.K. The researchers used contemporary data from the U.K. just before and after the end of wartime sugar rationing.

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Disease Research

New study reveals how a 'non-industrialized' style diet can reduce risk of chronic disease

Science Daily: Pharmacology News

JANUARY 23, 2025

Researchers have found that a newly developed diet inspired by the eating habits of non-industrialized societies can significantly reduce the risk of a number of chronic diseases -- and are to share recipes with the public.

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Disease Research

Discovery of 'new rules of the immune system' could improve treatment of inflammatory diseases, say scientists

Science Daily: Pharmacology News

JUNE 18, 2024

The discovery could lead to more targeted treatments, with fewer side-effects, for issues from lengthy COVID infections to autoimmune diseases like multiple sclerosis. Current anti-inflammatory drugs used for this purpose suppress the body's whole immune system, making patients more vulnerable to infection.

Treatment

Treatment Immune Response Disease Clinical Trials

Scientists Discover the Brain's Waste-Disposal System, With Clues to Alzheimer's Disease

Drugs.com

OCTOBER 8, 2024

8, 2024 -- The brain has a waste-disposal system that clears away junk proteins that contribute to the development of dementia and Alzheimer’s disease, a new study finds.Advanced imaging scans have revealed a network of fluid-filled s. TUESDAY, Oct.

Disease

New Blood Test Could Predict Women's 30-year Risk for Heart Disease

Drugs.com

SEPTEMBER 2, 2024

2, 2024 -- Could a simple blood test help predict a woman’s three-decade risk of heart disease?Yes, MONDAY, Sept. Yes, claims new research that found women with high levels of three specific blood markers had a greater than threefold increased risk for h.

Disease

Disease Research

Steady Rise in U.S. Cases of Tick-Borne Babesiosis Disease

Drugs.com

OCTOBER 9, 2024

9, 2024 -- Cases of a tick-borne parasitic disease have steadily increased in recent years, a new study shows.Rates of babesiosis increased an average 9% a year in the United States between 2015 and 2022, researchers reported in. WEDNESDAY, Oct.

Disease

Disease Research

Link Between Gum Disease, Brain Function Exists, Small Study Says

Drugs.com

JANUARY 13, 2025

13, 2025 -- Gum disease appears to disrupt brain activity, potentially increasing a persons risk of cognitive decline.People with gum disease experienced altered connections between different brain regions, compared to folks with good. MONDAY, Jan.

Disease

Fatty Liver Disease Now Affects 4 in 10 U.S. Adults

Drugs.com

NOVEMBER 13, 2024

13, 2024 -- Obesity, alcohol use and other factors are driving up rates of fatty liver disease among American adults, new research warns.By 2018, federal data showed that 42% of adults had some form of fatty liver disease -- higher. WEDNESDAY, Nov.

Disease

Disease Research

Over 100,000 U.S. Youth Battle Inflammatory Bowel Disease

Drugs.com

DECEMBER 2, 2024

2, 2024 -- Cases of inflammatory bowel disease (IBD) are rising at an alarming rate among young Americans, a new study reveals."Prevalence MONDAY, Dec.2, Prevalence rates [are] among the highest reported worldwide," said researcher Dr. Michael Kappelman, a.

Disease

Disease Research

Parkinson's Disease: New theory on the disease's origins and spread

Gene editing extends lifespan in mouse model of prion disease

Webinars

Trending Sources

Researchers devise new way to target and correct disease-related proteins

Webinars

Sweat health monitor measures levels of disease markers

Bridging Innovation & Patient Care: The Growing Role of AI

New Evidence Links Microplastics with Chronic Disease

Alcohol raises heart disease risk, particularly among women

Healthy eating in midlife linked to overall healthy aging

Moderate coffee and caffeine consumption is associated with lower risk of developing multiple cardiometabolic diseases, new study finds

Physical activity reduces stress-related brain activity to lower cardiovascular disease risk

Population shifts, risk factors may triple U.S. cardiovascular disease costs by 2050

Taming Parkinson's disease with intelligent brain pacemakers

Loneliness linked to higher risk of heart disease and stroke and susceptibility to infection

Some diabetes drugs tied to lower risk of dementia, Parkinson's disease

A new approach to detecting Alzheimer's disease

Xenon gas could protect against Alzheimer's disease: Mouse study

Human 'domainome' reveals root cause of heritable disease

Popular diabetes and weight-loss drug may reduce risk of Alzheimer's disease

Ozempic Could Curb Progression of Diabetes-Linked Liver Disease

'Weekend warrior' physical activity may help protect against more than 200 diseases

Gum Disease Germs Could Help Trigger Cancer

AI Helps Spot Liver Disease Early

Gum Disease & Diabetes: A Strong Link

Novel bone marrow transplant can cure sickle cell disease, study suggests

Doctors could soon use facial temperature for early diagnosis of metabolic diseases

Microrobot-packed pill shows promise for treating inflammatory bowel disease in mice

Biological organ ages predict disease risk decades in advance

Spinal cord stimulation restores neural function, targets key feature of progressive neurodegenerative disease

Low-level traffic air pollution linked to liver damage and fatty liver disease

Once Again, Tuberculosis Becomes World's Top Infectious Disease Killer

Ozempic Curbs Kidney Disease in Obese People Without Diabetes

Ignore antifungal resistance in fungal disease at your peril, warn top scientists

All in the eyes: High resolution retinal maps aid disease diagnoses

Ozempic Lowers Odds for Death, Illness in People With Kidney Disease and Type 2 Diabetes

Mapping 1.6 million gut cells to find new ways treat disease

Restricting sugar consumption in utero and in early childhood significantly reduces risk of midlife chronic disease

New study reveals how a 'non-industrialized' style diet can reduce risk of chronic disease

Discovery of 'new rules of the immune system' could improve treatment of inflammatory diseases, say scientists

Scientists Discover the Brain's Waste-Disposal System, With Clues to Alzheimer's Disease

New Blood Test Could Predict Women's 30-year Risk for Heart Disease

Steady Rise in U.S. Cases of Tick-Borne Babesiosis Disease

Link Between Gum Disease, Brain Function Exists, Small Study Says

Fatty Liver Disease Now Affects 4 in 10 U.S. Adults

Over 100,000 U.S. Youth Battle Inflammatory Bowel Disease

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