Science Daily: Pharmacology News

AUGUST 28, 2023

The stakes of their findings are high: a ruptured nucleus can lead to elevated DNA damage that is characteristic of many diseases, including cancer.

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DNA Regulations Disease Research 189

Science Daily: Pharmacology News

OCTOBER 9, 2024

Genome-wide association studies have great potential for advancing our understanding of the genetic background of diseases, but so far, few association studies have focused on maternal and newborn diseases, and most have been based on predominantly European populations.

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Science Daily: Pharmacology News

AUGUST 10, 2023

Creating new technologically advanced sensors, scientists have engineered bacteria that detect the presence of tumor DNA in live organisms. Their innovation could pave the way to new biosensors capable of identifying various infections, cancers and other diseases.

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DNA Engineering Research Disease 189

Science Daily: Pharmacology News

AUGUST 20, 2024

A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding revealed a long-postulated hidden spatial grammar embedded in DNA.

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Government DNA Regulations Disease 328

Science Daily: Pharmacology News

JUNE 12, 2024

Mutations are changes in the molecular 'letters' that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including cancer.

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DNA Disease 279

Science Daily: Pharmacology News

OCTOBER 8, 2024

The ability to synthesize artificial chains of TNA, which is inherently more stable than DNA, advances the discovery of potentially more powerful, precise therapeutic options to treat cancer and autoimmune, metabolic and infectious diseases.

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Engineering DNA Disease Research 305

Drugs.com

JANUARY 11, 2024

11, 2024 -- DNA locked in the bones and teeth of more than 5,000 humans who lived in Asia and Europe up to 34,000 years ago are providing vital clues to a myriad of present-day medical conditions.The descendants of these ancient. THURSDAY, Jan.

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DNA Disease 246

Science Daily: Pharmacology News

MAY 28, 2024

Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality.

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DNA Disease Research 309

Broad Institute

AUGUST 16, 2023

Nuclear DNA influences variation in mitochondrial DNA By Allessandra DiCorato August 16, 2023 Breadcrumb Home Nuclear DNA influences variation in mitochondrial DNA Whole genomes from hundreds of thousands of people reveal new complexity in how the nuclear and mitochondrial genomes interact, which may influence how cells produce energy.

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DNA Molecular Biology Disease Regulations 98

PLOS: DNA Science

DECEMBER 14, 2023

“Meet Invisible Woods: a clean, refreshing scent revived from extinct flower DNA ,” beneath an image of “origin flower” Wendlandia angustifolia. • compare the DNA sequence to similar genes in other species. • tweak a lab-made copy of the DNA sequence using clues from other plant species.

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DNA Production Science Disease 119

Chemical Biology and Drug Design

APRIL 4, 2025

Subsequently, 2-HG competitively suppresses a range of -KG-dependent dioxygenase activities, ultimately leading to hypermethylation of DNA or histones, which in turn causes the occurrence of various malignant tumors, including acute myeloid leukemia (AML), glioma, and chondrosarcoma.

Small Molecule 100

Small Molecule Drugs DNA Treatment 100

Chemical Biology and Drug Design

JANUARY 29, 2024

MGMT mRNA expression was significantly increased in CD138+ myeloma cells compared with their matched CD138-nontumorigenic cells and inhibition of MGMT by its specific inhibitor lomeguatrib in MM cells reduced DNA repair, cell viability, and S phase entry and increased DNA damage and apoptosis.

DNA 100

DNA Treatment Disease Research 100

Broad Institute

APRIL 5, 2025

The organization has honored Liu for the development of the gene editing platforms base editing and prime editing, which can correct the vast majority of known disease-causing genetic variations and have already been used in at least 15 clinical trials, with life-saving results.

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Science Clinical Trials DNA Disease 144

SCIENMAG: Medicine & Health

JUNE 21, 2023

HOUSTON – (June 21, 2023) – Rice University bioengineers have demonstrated a low-cost, point-of-care DNA test for HPV infections that could make cervical cancer screening more accessible in low- and middle-income countries where the disease kills more than 300,000 women each year.

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DNA Disease Engineering 89

BioPharma Drive: Drug Pricing

FEBRUARY 15, 2024

The partnership will use Intellia's "DNA writing” technology, and initially focus on people with the lung disease who have limited or no available treatment options.

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DNA Treatment Disease 184

PLOS: DNA Science

JANUARY 25, 2024

We can learn about life, past and present, anywhere we find DNA and determine its sequence. DNA Science has described intriguing sources of environmental DNA, aka eDNA: DNA in Strange Places: Hippo Poop, Zoo Air, and Cave Dirt and A Glimpse of the Ocean’s Twilight Zone Through Environmental DNA.

Disease 97

Disease DNA Science Virus 97

Broad Institute

OCTOBER 23, 2023

By Makenzie Kohler October 23, 2023 People of South Asian ancestry around the world have more than double the risk of developing cardiometabolic diseases like diabetes, heart attack, and stroke compared to other populations. Some participants will receive a kit in the mail that they can use to send a saliva sample for DNA analysis.

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Disease Research Hospitals DNA 145

Broad Institute

APRIL 2, 2024

Scientists link certain gut bacteria to lower heart disease risk By Allessandra DiCorato April 2, 2024 Breadcrumb Home Scientists link certain gut bacteria to lower heart disease risk Study finds several species of cholesterol-metabolizing bacteria in people with lower cholesterol levels.

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Disease Medical Schools Hospitals DNA 145

Chemical Biology and Drug Design

FEBRUARY 26, 2024

The mechanism research revealed that cinnamaldehyde activated the Nrf2 pathway to attenuate lipid peroxidation and repair DNA damage to protect cardiomyocytes from ischemia/reperfusion injury in the OGD/R-induced H9C2 cardiomyocyte model. The severity of DNA damage was assessed by tail moment (TM) values using alkaline comet assay.

DNA 100

DNA Treatment Disease Research 100

SCIENMAG: Medicine & Health

FEBRUARY 22, 2024

Elenagen belongs to a novel class of biological agents, supercoiled circular DNA (plasmids). Credit: CureLab Oncology Inc. BOSTON, February […]

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DNA Disease 71

Covalent Modifiers

DECEMBER 11, 2023

Mutations that impair nuclear protein association with chromatin are implicated in numerous diseases. Using covalent scout fragments, KB02 and KB05, we identified ligandable cysteines on proteins involved in spindle assembly, DNA repair, and transcriptional regulation, such as Cys101 of histone acetyltransferase 1 (HAT1).

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Small Molecule DNA Regulations Disease 162

Broad Institute

JANUARY 18, 2024

McAlpine January 18, 2024 Credit: Susanna Hamilton, Broad Communications One of the new "priming agents" works by preventing immune cells from engulfing tumor DNA circulating in the bloodstream. Liquid biopsies promise to transform how cancers are diagnosed, monitored, and treated by detecting DNA that tumors shed into the blood.

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DNA Engineering Science Disease 133

Broad Institute

JUNE 10, 2024

The advance, from the lab of Broad core institute member David Liu , could one day help researchers develop a single gene therapy for diseases such as cystic fibrosis that are caused by one of hundreds or thousands of different mutations in a gene.

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DNA Engineering Therapies Disease 144

SCIENMAG: Medicine & Health

JULY 19, 2023

Together, they have published dozens of papers on the mechanics of mitochondrial DNA and RNA in a single-celled, disease-causing parasite called Trypanosoma brucei. As molecular biologists at Boston University and as husband and wife, Ruslan Afasizhev and Inna Afasizheva, have worked together for decades.

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RNA Disease DNA 83

Broad Institute

AUGUST 31, 2023

Related News Next generation prime editing systems move closer to possible therapeutic applications New CRISPR genome editing system offers a wide range of versatility in human cells Prime editing technologies allow scientists to precisely edit the genome in a variety of ways and could one day be used to treat genetic diseases.

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DNA RNA Engineering Laboratories 145

Broad Institute

JANUARY 8, 2024

In the new work published today in Nature Biotechnology , the team adapted engineered virus-like particles (eVLPs) that they had previously designed to carry base editors — another type of precision gene editor that makes single-letter changes in DNA. By Sarah C.P.

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Engineering Research Virus DNA 144

Fierce BioTech

AUGUST 26, 2024

Biotherapeutics are transforming healthcare for over 350 million patients globally, tackling everything from cancer and diabetes to rare diseases. |

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DNA Disease 52

Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. They needed reference materials for the disease in order to develop and validate diagnostic tests.

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DNA Organic Chemistry Science Virus 116

Covalent Modifiers

MARCH 1, 2024

Especially important is understanding how aberrant carbon imbalances are connected to human diseases such as cancer, liver diseases, and asthma. Although the chronic exposure of toxic aldehydes is correlated to disease states, biological mechanisms of aldehyde signaling and their relation to carbon metabolism remain underexplored.

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Regulations DNA Disease Production 147

Drug Target Review

MAY 28, 2024

How do senescent cells contribute to degenerative diseases, cancer, and immuno-senescence? Telomere damage, epigenetic dysregulation, DNA damage and mitochondrial dysfunction are primary drivers of damage in aging. This is responsible for promoting inflammation, degenerative diseases, and cancer.

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Disease DNA Production 78

ASPET

SEPTEMBER 16, 2024

Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance.

Pharmacogenetics 100

Pharmacogenetics DNA Treatment Pharmacokinetics 100

Broad Institute

OCTOBER 23, 2024

They knew that discovering the genetic cause of her disorder would help them find other people like her, help get the condition formally recognized as a new disease, and help them better advocate for research into new treatments. This is the first human disease caused by loss of one copy of a lncRNA gene.

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DNA RNA Disease Hospitals 128

Drug Target Review

AUGUST 3, 2023

Clinical trials are now underway for various genetic subtypes of both rare and common diseases, on the understanding that medications utilising genetic biomarkers have a significantly higher chance of success. There are clinical trials underway for genetic subtypes of rare and common diseases.

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DNA Clinical Trials Trials Disease 52

Drug Target Review

JUNE 28, 2023

When faced with a viral threat, bacterial cells developed an immune response by capturing and copying DNA fragments of viruses. This allowed bacteria to recognise subsequent attacks and cleave the viral DNA to stop the viral infection. It was also discovered that the Cas enzyme was responsible for DNA cleavage.

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Engineering DNA Immune Response RNA 98

NIH Director's Blog: Drug Development

MARCH 11, 2014

Credit: Jane Ades, National Human Genome Research Institute, NIH Type 2 diabetes (T2D) tends to run in families, and over the last five years the application of genomic technologies has led to discovery of more than 60 specific DNA variants that contribute to risk. 2012;7(7):e40972. Link: Accelerating Medicines Partnership.

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DNA Drugs Disease Research Laboratories 52

Broad Institute

MARCH 26, 2024

The team analyzed ancient DNA and traced the variant all the way back to the first people to enter the Americas about 13,000 years ago. "We The researchers then analyzed ancient DNA samples to understand when the risk variant arose in human history. Further investigation revealed that the variant was promoted by natural selection.

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DNA Research Disease Treatment 59

Broad Institute

OCTOBER 3, 2024

Epilepsy also has several subtypes, and while one group called developmental encephalopathies have been connected to several genes, other forms of the disease are less well understood. The exomes revealed connections between disease risk and several genes involved in the transmission of signals across the synapses between neurons.

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DNA Doctors Treatment Disease 133