Drug Target Review

JANUARY 15, 2024

An important limitation of antibodies against tumour antigens is that these agents direct responses to molecular targets present on the surface of the cell. Figure 1: HLA Class I presentation of peptides derived from intracellular antigens. As described below, it also presents challenges and opportunities for TCR-based therapeutics.

Engineering 110

Engineering DNA Virus Immune Response 110

Drug Target Review

JANUARY 8, 2024

It is no mystery that as we age our health starts to deteriorate, and we become increasingly susceptible to diseases. Through years of scientific exploration and research, we now know there are several biological changes that make our bodies more susceptible to disease or injury, and we can target those with therapeutic interventions.

Science 145

Science Disease FDA Approval Clinical Trials 145

PLOS: DNA Science

AUGUST 24, 2023

“Pangenomics” is a newish term, referring to ways that a species’ genome can vary, DNA base by DNA base. I wrote The Age of the Pangenome Dawns here at DNA Science last year, about the Human Pangenome Reference Consortium. A genome of 3,054,832 billion DNA base pairs can vary in many ways.

DNA 98

DNA Disease Science Research 98

Broad Institute

OCTOBER 3, 2024

Epilepsy also has several subtypes, and while one group called developmental encephalopathies have been connected to several genes, other forms of the disease are less well understood. The exomes revealed connections between disease risk and several genes involved in the transmission of signals across the synapses between neurons.

DNA 133

DNA Doctors Treatment Disease 133

Drug Target Review

JULY 5, 2023

Induced pluripotent stem cell (iPSC) therapies have the potential to treat a wide variety of devastating diseases. Please summarise Eterna Therapeutics’ ($ERNA) new research at ASGCT on a cell therapy approach that integrates multiple cell types to emulate the natural immune system’s fight against diseases?

Therapies 103

Therapies DNA Engineering Virus 103

Broad Institute

MARCH 26, 2024

The team analyzed ancient DNA and traced the variant all the way back to the first people to enter the Americas about 13,000 years ago. "We The researchers then analyzed ancient DNA samples to understand when the risk variant arose in human history. Further investigation revealed that the variant was promoted by natural selection.

DNA 59

DNA Research Disease Treatment 59

Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. They needed reference materials for the disease in order to develop and validate diagnostic tests.

DNA 116

DNA Organic Chemistry Science Virus 116

Drug Target Review

JANUARY 24, 2024

Scientists from Northwestern Medicine have demonstrated that RNA interference could have a crucial role in the onset and development of Alzheimer’s disease (AD). Alzheimer’s disease Alzheimer’s is the most common cause of dementia. The team found very short sequences present in some of these sRNAs.

RNA 64

RNA Disease DNA Engineering 64

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell. These mutations are called clonal mutations or clonal neoantigens.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

DrugBaron

JANUARY 8, 2021

Here is a disease that is caused by the lack of functional dystrophin in the muscles of these boys. The underlying assumption of most gene therapy procedures, irrespective of the disease being targeted, is that restoration of a wild-type DNA sequence will alone be sufficient to normalise the phenotype of the individual.

DNA 100

DNA Therapies Disease Production 100

KIF1A

JANUARY 13, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. As one cell turns into two, its DNA must be replicated and then pulled apart, so that when the cell divides each has all the DNA it needs to function.

DNA 105

DNA Regulations Drug Development Disease 105

Chemical Biology and Drug Design

NOVEMBER 23, 2023

The symptoms of the disease include delusions and hallucinations, associated with extremely disordered behavior and thinking, which may affect the daily lives of the patients. Advancements in technology have led to understanding the dynamics of the disease and the identification of the underlying causes.

Therapies 100

Therapies DNA Regulations Disease 100

Drug Target Review

JANUARY 26, 2024

To find a DNA fragment that contained the intact ACE2 gene, complete with its embedded regulatory information, they searched libraries of cloned DNA fragments generated as part of the Human Genome Project. Several of the mouse cell clones produced about 50 times more ACE2 than is normally present on mouse cells.

Production 114

Production DNA Virus Protein Expression 114

Drug Target Review

DECEMBER 21, 2023

To provide comprehensive insights into ongoing developments, we are pleased to present the latest edition of Drug Target Review. Dr Piotr Trzonkowski, from the University of Gdansk, highlights how TREGs offer hope for personalised medicine in autoimmune diseases.

Drugs 98

Drugs DNA Engineering Disease 98

PLOS: DNA Science

APRIL 20, 2023

DNA is a sleek double helix, with “rungs” consisting of a purine base paired with a smaller pyrimidine base: adenine (A) with thymine (T) and guanine (G) with cytosine (C). . ” DNA encodes amino acid sequences comprising proteins, which impart traits. Watson and F.

DNA 52

DNA Virus Science RNA 52

Broad Institute

FEBRUARY 16, 2024

We didn’t expect that frequency of genetic variants would correlate with clinical presentation, but that amazingly seems to be what we’re seeing.” Their analyses demonstrated that the combination of common and rare genetic variants in youth-onset T2D have a greater influence on disease risk than in the adult-onset form.

Medical Schools 133

Medical Schools Hospitals Disease DNA 133

PLOS: DNA Science

MAY 23, 2024

Researchers roughly date events that led to today’s crops by considering changes in DNA sequences and mutation rates. Archeological evidence, such as preserved seeds, complements DNA sequence studies. That inbreeding has made the crop susceptible to many plant pests and diseases. canephora (Robusta) and C. eugenioides. .

DNA 98

DNA Research Science Disease 98

Drug Target Review

NOVEMBER 13, 2023

Regulatory T cells (Treg) cells are specialised immune cells that are essential for maintaining peripheral tolerance, preventing autoimmune diseases, and limiting chronic inflammatory diseases. However, they also limit beneficial responses by suppressing sterilising immunity and limiting antitumour immunity.

Government 104

Government DNA RNA Regulations 104

PLOS: DNA Science

OCTOBER 19, 2023

Last week DNA Science covered a setback in a clinical trial of a gene therapy for Duchenne muscular dystrophy (DMD). Also recently, FDA’s Cellular, Tissue, and Gene Therapies Advisory Committe turned down a stem cell treatment for amyotrophic lateral sclerosis, aka ALS, Lou Gehrig’s disease, or motor neuron disease.

Therapies 111

Therapies FDA Clinical Trials DNA 111

NIH Director's Blog: Drug Discovery

MARCH 8, 2016

Instead of the black, printed stripes of the Universal Product Codes (UPCs) that we see on everything from package deliveries to clothing tags, they used short, unique snippets of DNA to label cells. DNA barcoding has already empowered single-cell analysis, including for nerve cells in the brain.

DNA 52

DNA Drugs Small Molecule FDA Approval 52

The Pharma Data

NOVEMBER 26, 2020

26, 2020 /PRNewswire/ — BASE10 Genetics and DNA Link today announced their collaboration on a research project to evaluate the usability of DNA Link ‘ s AccuFind COVID-19 IgG antibody test in a healthcare setting. At present, most antibody tests on the market require samples to be sent to a lab for analysis.

DNA 52

DNA Nurses Research Laboratories 52

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Doctors in training are told that when they hear hoofbeats, they should think horses, not zebras; rare diseases are the exception, not the rule. After copying the DNA to form a big pool, each piece is sequenced.

DNA 83

DNA Laboratories Hospitals Virus 83

Drug Target Review

AUGUST 16, 2023

However, a study published in eLight , led by Professor Xiangheng Xiao from Wuhan University, presents a game-changing approach that merges SERS with artificial intelligence (AI) for cancer screening (SERS-AICS). Direct detection of early-stage cancers using circulating tumor DNA. percent, sensitivity of 95.40 References 1.

DNA 98

DNA Disease Therapies Treatment 98

The Pharma Data

NOVEMBER 15, 2020

Triplet’s chief executive officer, president, and founder, will present at the Stifel Virtual Healthcare Conference taking place November 16-18, 2020. Dr. Bermingham will discuss Triplet’s recent activities, including: Dr. Bermingham’s presentation details are as follows: Date: Wednesday, November 18 Time: 9:20 a.m.

DNA 40

DNA Engineering Disease Treatment 40

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

DNA 52

DNA RNA Science Protein Expression 52

The Pharma Data

SEPTEMBER 6, 2021

First data to be presented from the phase II coopERA Breast Cancer study evaluating neoadjuvant giredestrant treatment for oestrogen receptor (ER)-positive, HER2-negative breast cancer. Breast Cancer Highlights. Lung Cancer Highlights.

Treatment 52

Treatment Therapies DNA Trials 52

The Pharma Data

NOVEMBER 18, 2020

Presentations to highlight the OBI-833 Phase 1 clinical study results in non-small cell lung cancer (NSCLC) and the dose escalation cohort. These results will be presented by the lead investigators of OBI Pharma’s novel anti-Globo H therapeutic cancer vaccine, OBI-833. ” Presentation number: 397P / Poster: ID 680.

Vaccine 52

Vaccine Small Molecule Immune Response Hospitals 52

PLOS: DNA Science

OCTOBER 17, 2024

FDA approved a treatment for type 3 of the ultra-rare genetic disease September 20. The quest has been ongoing for three decades, said Laurie Turner, Family Services Manager of the National Niemann-Pick Disease Foundation. The original approved was in 2003 to treat a type of Gaucher disease. Average length of life is 13 years.

Disease 52

Disease FDA Approval Drugs Treatment 52

Codon

AUGUST 26, 2024

Credit: OpenStax College The innate immune system has been evolutionarily successful for three reasons: its tools target the most fundamental properties of viruses , act as prophylactics —meaning they prevent diseases, rather than treat them—and are widespread. Existing medicines only pose a partial solution.

RNA 86

RNA Virus DNA Vaccine 86

Drug Target Review

AUGUST 9, 2023

Published on bit.bio’s website, this article authored by Dr Tony Oosterveen dives into the close relationship between FTD and ALS with a focus on mechanisms underlying the neuropathology of both diseases. ALS is the most common motor neuron disease and is estimated to affect more than 80,000 people worldwide.

RNA 98

RNA Regulations Disease DNA 98

Codon

FEBRUARY 13, 2024

alone, according to the Centers for Disease Control and Prevention. Some algorithms simply look for important similarities between phage and bacterial DNA sequences, a signal of the extensive gene-swapping that goes on when a particular virus and bacteria have shared history. The tech for this process already exists.

Therapies 117

Therapies DNA Virus Clinical Trials 117

The Pharma Data

APRIL 8, 2021

Leadership in DNA damage response demonstrated in multiple presentations for AZD5305, a next-generation PARP1 selective inhibitor. Data for AZD5305 will demonstrate how the next wave of DNA damage response medicines can build on the success of PARP inhibitors, potentially allowing patients to stay on treatment longer.

DNA 52

DNA Immune Response Therapies Treatment 52

New Drug Approvals

SEPTEMBER 29, 2024

gingivalis has been called a risk factor for Alzheimer’s disease ( Kanagasingam et al., gingivalis DNA was detected in postmortem cortices from people with AD and healthy controls, and in CSF of AD patients ( Jan 2019 news on Dominy et al., gingivalis is associated with cardiovascular disease. All volunteers with AD had P.

Small Molecule 62

Small Molecule DNA Disease Trials 62

Drug Target Review

JULY 24, 2023

The study suggests that this regulatory system could be a potential target for future malaria treatments, offering hope for combatting this deadly disease that affects millions worldwide. However, the underlying mechanism remains elusive and the presently found apicoplast regulation may give insights into the missing link.

RNA 98

RNA Regulations Bioinformatics Laboratories 98

Codon

DECEMBER 12, 2024

It’s important to note that the 300-page report, while presenting detailed evidence for the potential harms of mirrored life, uses painstakingly speculative language. DNA and RNA molecules are also built from exclusively right-handed nucleic acids. It gives humanity time to steer away. This is one of them.

DNA 81

DNA RNA Vaccine Virus 81

Drug Target Review

JUNE 9, 2023

One aspect of the collaboration focuses on screening and identification of therapeutic T-cell receptors (TCRs) to target a common shared neoantigen present in many cancer patients. What types of diseases or conditions were targeted in the pre-clinical research phase? a healthcare informatics company.

Treatment 105

Treatment Packaging Clinical Research Therapies 105

The Pharma Data

DECEMBER 5, 2020

5, 2020 — A pair of new gene therapies promise a potentially lasting cure for sickle cell disease by subtly altering the genetic information in patients’ bone marrow cells, researchers report. The German study is also scheduled for presentation on Saturday at the American Society of Hematology’s virtual annual meeting.

Therapies 52

Therapies Disease Medical Schools Virus 52