Science Daily: Pharmacology News

OCTOBER 8, 2024

The ability to synthesize artificial chains of TNA, which is inherently more stable than DNA, advances the discovery of potentially more powerful, precise therapeutic options to treat cancer and autoimmune, metabolic and infectious diseases.

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Science Daily: Pharmacology News

MAY 28, 2024

Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality.

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Broad Institute

JUNE 27, 2024

Science (2024) Related content New gene delivery vehicle shows promise for human brain gene therapy My Quest to Cure Prion Disease — Before It’s Too Late | Sonia Vallabh | TED Prion diseases lead to rapid neurodegeneration and death and are caused by misshapen versions of the prion protein in the brain.

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Disease Therapies Engineering Clinical Trials 142

Broad Institute

AUGUST 16, 2023

Nuclear DNA influences variation in mitochondrial DNA By Allessandra DiCorato August 16, 2023 Breadcrumb Home Nuclear DNA influences variation in mitochondrial DNA Whole genomes from hundreds of thousands of people reveal new complexity in how the nuclear and mitochondrial genomes interact, which may influence how cells produce energy.

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DNA Molecular Biology Disease Regulations 98

PLOS: DNA Science

DECEMBER 14, 2023

“Meet Invisible Woods: a clean, refreshing scent revived from extinct flower DNA ,” beneath an image of “origin flower” Wendlandia angustifolia. Before I dig into the science, I’ll relate taking a quiz on the Future Society website that would help me choose a product. On to the science.

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DNA Production Science Disease 119

PLOS: DNA Science

AUGUST 17, 2023

The Maui firestorm was so vast and fast that most identification of human remains will come from bits of persisting DNA from mitochondria. MtDNA in Forensics and Genealogy Mitochondrial DNA (mtDNA) is used in forensics to match the tiniest bits of human remains to families. Mitochondrial DNA is also far more abundant than nuclear DNA.

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DNA Disease Science Research 98

PLOS: DNA Science

JANUARY 25, 2024

We can learn about life, past and present, anywhere we find DNA and determine its sequence. DNA Science has described intriguing sources of environmental DNA, aka eDNA: DNA in Strange Places: Hippo Poop, Zoo Air, and Cave Dirt and A Glimpse of the Ocean’s Twilight Zone Through Environmental DNA.

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Disease DNA Science Virus 98

Drug Target Review

JANUARY 8, 2024

It is no mystery that as we age our health starts to deteriorate, and we become increasingly susceptible to diseases. Through years of scientific exploration and research, we now know there are several biological changes that make our bodies more susceptible to disease or injury, and we can target those with therapeutic interventions.

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Science Disease FDA Approval Clinical Trials 145

Broad Institute

OCTOBER 23, 2023

By Makenzie Kohler October 23, 2023 People of South Asian ancestry around the world have more than double the risk of developing cardiometabolic diseases like diabetes, heart attack, and stroke compared to other populations. Some participants will receive a kit in the mail that they can use to send a saliva sample for DNA analysis.

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Disease Research Hospitals DNA 145

Broad Institute

JUNE 28, 2023

Merkin Prize in Biomedical Technology for developing an efficient, automated technology for synthesizing DNA. The chemical reactions that he discovered in the early 1980s to accurately and quickly assemble nucleotides into strands of DNA provided an essential element in the development of modern molecular medicine.

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DNA RNA Science Therapies 98

Broad Institute

JANUARY 18, 2024

McAlpine January 18, 2024 Credit: Susanna Hamilton, Broad Communications One of the new "priming agents" works by preventing immune cells from engulfing tumor DNA circulating in the bloodstream. Liquid biopsies promise to transform how cancers are diagnosed, monitored, and treated by detecting DNA that tumors shed into the blood.

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DNA Engineering Science Disease 133

PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages.

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PLOS: DNA Science

FEBRUARY 1, 2024

Five people treated for pituitary dwarfism decades ago with human growth hormone (hGH) pooled from cadavers have shown cognitive decline reminiscent of early-onset Alzheimer’s disease. Recombinant DNA technology has since provided a pure source of the hormone. .” More than 85 animal species develop prion diseases.

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Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. They had the science and the technology but not the business model. It was right after synbio 1.0

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DNA Organic Chemistry Science Virus 116

Broad Institute

JANUARY 8, 2024

In the new work published today in Nature Biotechnology , the team adapted engineered virus-like particles (eVLPs) that they had previously designed to carry base editors — another type of precision gene editor that makes single-letter changes in DNA. By Sarah C.P.

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Engineering Research Virus DNA 144

Covalent Modifiers

MARCH 1, 2024

CHANG Science 2023 382, 6670 DOI: 10.1126/science.abp9201 INTRODUCTION One-carbon metabolism manages cellular carbon pools by detoxifying highly reactive carbon species, such as aldehydes, and diverting their carbon toward the biosynthesis of useful products, including amino acids and nucleotides. DINGLER, CHRISTOPHER L. MILLINGTON, CARLOS A.

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Regulations DNA Disease Production 147

Broad Institute

AUGUST 31, 2023

Related News Next generation prime editing systems move closer to possible therapeutic applications New CRISPR genome editing system offers a wide range of versatility in human cells Prime editing technologies allow scientists to precisely edit the genome in a variety of ways and could one day be used to treat genetic diseases.

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DNA RNA Engineering Laboratories 145

PLOS: DNA Science

MAY 16, 2024

These factors are converging to enable both identification of novel infectious diseases as well as microbial resistance, before these threats can impact public health, write a team from the European Society for Clinical Microbiology and Infectious Diseases in Frontiers in Science. COVID clearly caught us off guard.

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Virus DNA RNA Vaccine 98

PLOS: DNA Science

AUGUST 24, 2023

“Pangenomics” is a newish term, referring to ways that a species’ genome can vary, DNA base by DNA base. I wrote The Age of the Pangenome Dawns here at DNA Science last year, about the Human Pangenome Reference Consortium. A genome of 3,054,832 billion DNA base pairs can vary in many ways.

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DNA Disease Science Research 97

Broad Institute

OCTOBER 23, 2024

They knew that discovering the genetic cause of her disorder would help them find other people like her, help get the condition formally recognized as a new disease, and help them better advocate for research into new treatments. This is the first human disease caused by loss of one copy of a lncRNA gene.

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DNA RNA Disease Hospitals 128

Broad Institute

NOVEMBER 23, 2023

The work appears today in Science. The scientists found a surprising number and diversity of CRISPR systems, including ones that could make edits to DNA in human cells, others that can target RNA, and many with a variety of other functions. Zhang’s team showed that two of these systems could make short edits in the DNA of human cells.

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RNA DNA Engineering Science 135

PLOS: DNA Science

NOVEMBER 2, 2023

The popular view of science consisting of breakthroughs and proofs is not accurate. Vague Definitions and Examples from Nature All genetics textbooks, including mine, relate the convergence of experimental evidence that led Watson and Crick to deduce DNA’s structure. ” Science would explain it, Srb and Owen write.

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DNA Disease Science Doctors 105

PLOS: DNA Science

MARCH 28, 2024

A new drug has entered the arsenal against Duchenne muscular dystrophy (DMD), a genetic disease that affects boys and is challenging to treat. million DNA bases. The exons are nestled amongst the much longer introns, which are DNA sequences that are not represented in the final protein. The gene presents a complex landscape.

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FDA Approval Treatment FDA DNA 97

Broad Institute

NOVEMBER 13, 2023

Liquid biopsies enable clinicians to find and analyze tumor DNA in a patient’s blood sample to detect cancer early, monitor cancer recurrence, assess the patient’s response to treatment, and measure other clinically important features in real time, without invasive procedures.

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DNA Medical Schools Treatment Therapies 116

PLOS: DNA Science

APRIL 20, 2023

DNA is a sleek double helix, with “rungs” consisting of a purine base paired with a smaller pyrimidine base: adenine (A) with thymine (T) and guanine (G) with cytosine (C). . ” DNA encodes amino acid sequences comprising proteins, which impart traits. Watson and F. As a child, Mendel tended fruit trees.

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NIH Director's Blog: Drug Development

MARCH 11, 2014

Credit: Jane Ades, National Human Genome Research Institute, NIH Type 2 diabetes (T2D) tends to run in families, and over the last five years the application of genomic technologies has led to discovery of more than 60 specific DNA variants that contribute to risk. 2012;7(7):e40972. Link: Accelerating Medicines Partnership.

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PLOS: DNA Science

OCTOBER 19, 2023

Last week DNA Science covered a setback in a clinical trial of a gene therapy for Duchenne muscular dystrophy (DMD). Also recently, FDA’s Cellular, Tissue, and Gene Therapies Advisory Committe turned down a stem cell treatment for amyotrophic lateral sclerosis, aka ALS, Lou Gehrig’s disease, or motor neuron disease.

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Therapies FDA Clinical Trials Disease 107

KIF1A

MAY 4, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. By talking to groups with these mutations, we may identify other diseases whose patients have KIF1A variants. Wangyang Dai Wangyang is a master student in the M.A.

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Science Medical Schools Research RNA 116

PLOS: DNA Science

FEBRUARY 8, 2024

Already, engineered probiotics have been used to treat metabolic disorders like inflammatory bowel disease and obesity, single-gene conditions like PKU, and bacterial infections common in people who have cystic fibrosis. Or, add genes to arm a host species to resist a specific infectious disease. appeared first on DNA Science.

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Immune Response DNA Engineering Virus 98

PLOS: DNA Science

MAY 23, 2024

We’ve used genomic information in plants alive today to go back in time and paint the most accurate picture possible of Arabica’s long history, as well as determine how modern cultivated varieties are related to each other,” said author Victor Albert, Empire Innovation Professor in the UB Department of Biological Sciences.

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DNA Research Science Disease 90

PLOS: DNA Science

SEPTEMBER 7, 2023

My Career I’ve been writing life science tomes for a long time. As genetics morphed into genomics, artificial intelligence stepped in, layering the combinatorial information of comparative genomics onto DNA sequences. AI may quickly assemble a table listing DNA replication enzymes or compile technology timelines.

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DNA Science Therapies Licensing 98

NIH Director's Blog: Drug Discovery

MARCH 8, 2016

Instead of the black, printed stripes of the Universal Product Codes (UPCs) that we see on everything from package deliveries to clothing tags, they used short, unique snippets of DNA to label cells. DNA barcoding has already empowered single-cell analysis, including for nerve cells in the brain. PRISM consists of two key components.

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DNA Drugs Small Molecule FDA Approval 52

PLOS: DNA Science

MARCH 21, 2024

Lenmeldy adds functional genes that encode the enzyme arylsulfatase A (ARSA) to bone marrow stem cells taken from children who have inherited the disease, but haven’t yet developed symptoms, which typically begin around age 2 or 3. Each of their children would face a 1 in 4 chance of inheriting the disease.

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LifeSciVC

APRIL 26, 2024

Beyond simply backing great science (separating the wheat from the chafe), setting a company up properly is critical, and early choices can get locked into the DNA of the company. Some continue to do so today, unfortunately, but there appears to be less of it happening. Second, great teams of truly experienced leaders are scarce.

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DNA Science Marketing Clinical Trials 112

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

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DNA RNA Science Protein Expression 52

Drug Target Review

DECEMBER 21, 2023

Dr Piotr Trzonkowski, from the University of Gdansk, highlights how TREGs offer hope for personalised medicine in autoimmune diseases. Dr Susanne Rafelski, from the Allen Institute for Cell Science, presents a framework for comprehending cell organisation and variation.

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Drugs DNA Engineering Disease 98

DrugBank

MAY 22, 2024

These tough nuts to crack in medical science—biological targets known to play roles in diseases but resistant to traditional drug design—are now seeing new strategies that shift the paradigm from "undruggable" to "druggable." Beyond Proteins: DNA and RNA Frontier The story doesn’t end with proteins.

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