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With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks

Broad Institute

They found significant associations between the thinning of different retinal layers and increased risk of developing ocular, cardiac, pulmonary, metabolic, and neuropsychiatric diseases and identified genes that are associated with retinal layer thickness. Their findings are published in Science Translational Medicine. “We

Disease 124
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Largest-ever genetic study of epilepsy finds possible therapeutic targets

Broad Institute

In the future, the results could also help doctors tailor treatments to a patient’s genome. Epilepsy also has several subtypes, and while one group called developmental encephalopathies have been connected to several genes, other forms of the disease are less well understood. Epilepsy is one of the most common neurological disorders.

DNA 133
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How AI is accelerating the future of precision medicine

Drug Target Review

How does the integration of Real-World Data (RWD) with genomic biomarker data contribute to a more comprehensive understanding of disease progression and treatment response? Biomarker information is also useful for tracking progression of the disease and treatment response. Most drugs do not work in all people.

Doctors 111
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Simple test for flu could improve diagnosis and surveillance

Broad Institute

The test, developed by a team from the Broad Institute of MIT and Harvard and Princeton University, and supported by the US Centers for Disease Control and Prevention, uses CRISPR to distinguish between the two main types of seasonal flu, influenza A and B, as well as seasonal flu subtypes H1N1 and H3N2. The Journal of Molecular Diagnostics.

Virus 144
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Spirulina’s role in shaping the future of preventative biologics

Drug Target Review

Finrow highlights the economic challenges within the sector, particularly the reluctance of doctors to use new antibiotics when cheaper generic options are available. “Doctors face incentives to prioritise generic antibiotic use first because they are cheaper, leaving novel antibiotics as a last resort. Its simple in principle.

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To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives

Broad Institute

They knew that discovering the genetic cause of her disorder would help them find other people like her, help get the condition formally recognized as a new disease, and help them better advocate for research into new treatments. This is the first human disease caused by loss of one copy of a lncRNA gene.

DNA 128
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Zebrafish for Disease Modeling and Drug Screening in Pediatric Cancers

biobide

Pediatric cancers exhibit differences at the genetic level compared to the same form of adult disease, which may influence the selected treatment. This New Alternative Model (NAM) provides a platform for High-Content Screening through disease modeling through the transplantation of primary patient tumors into immunocompromised lines.

Disease 59