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Researchers design genetic therapy to prevent brain deterioration

Drug Discovery World

A research team at the Francis Crick Institute and Great Ormond Street Hospital (GOSH)/UCL Great Ormond Street Institute of Child Health have identified potential treatments for children with rare genetic conditions. The researchers have shown that problems with calcium underlie these progressive diseases.

Therapies 147
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With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks

Broad Institute

They found significant associations between the thinning of different retinal layers and increased risk of developing ocular, cardiac, pulmonary, metabolic, and neuropsychiatric diseases and identified genes that are associated with retinal layer thickness. Their findings are published in Science Translational Medicine. “We

Disease 124
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Researchers uncover genetic factors for severe Lassa fever

Broad Institute

Researchers uncover genetic factors for severe Lassa fever By Allessandra DiCorato February 8, 2024 Breadcrumb Home Researchers uncover genetic factors for severe Lassa fever New findings from an international collaboration pave the way for studies of highly infectious diseases in Africa such as Ebola.

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Zebrafish for Disease Modeling and Drug Screening in Pediatric Cancers

biobide

Pediatric cancers exhibit differences at the genetic level compared to the same form of adult disease, which may influence the selected treatment. How can research boost the discovery of specific therapies for childhood and adolescent cancers? This treatment was developed by performing a chemical screening on zebrafish.

Disease 59
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US researchers decipher how one gut bacterium influences immunity

Drug Discovery World

From immunity to metabolism to mental health, it seems like the gut microbiome has been linked to every aspect of human health and disease. A team led by researchers at HMS and the Broad has just accomplished the rare feat of connecting those dots for one important gut bacterium. Study after study had suggested that A. New doors open.

Research 130
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A close research partnership with African scientists helps solve the mystery of malaria-like illnesses

Broad Institute

By Claire Hendershot March 8, 2024 Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health via U.S. There are a lot of patients that they couldn’t treat unless it was malaria or a small host of other diseases. The bacteria causes infections with malaria-like symptoms.

Research 111
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Largest-ever genetic study of epilepsy finds possible therapeutic targets

Broad Institute

In the future, the results could also help doctors tailor treatments to a patient’s genome. Epilepsy also has several subtypes, and while one group called developmental encephalopathies have been connected to several genes, other forms of the disease are less well understood. Epilepsy is one of the most common neurological disorders.

DNA 72