PLOS: DNA Science

OCTOBER 12, 2023

In the final chapter of my 2012 book The Forever Fix: Gene Therapy and the Boy Who Saved It , I predicted that the technology would soon expand well beyond the rare disease world. Gene therapy clearly hasn’t had a major impact on health care, offering extremely expensive treatments for a few individuals with rare diseases.

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PLOS: DNA Science

OCTOBER 3, 2024

One of the oldest and most successful immunotherapies is simpler: a tamed version of a classic vaccine, against the infectious disease tuberculosis (TB). Their report appears in Disease Models and Mechanisms. He and other doctors who used them reported excellent results, especially in bone and soft-tissue sarcomas.

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PLOS: DNA Science

OCTOBER 19, 2023

Also recently, FDA’s Cellular, Tissue, and Gene Therapies Advisory Committe turned down a stem cell treatment for amyotrophic lateral sclerosis, aka ALS, Lou Gehrig’s disease, or motor neuron disease. ALS is a disease of adulthood, beginning typically between 40 and 70 years of age. Most ALS cases are sporadic.

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The Pharma Data

DECEMBER 31, 2020

31, 2020 — Blood vessel damage and inflammation in the brains of deceased COVID-19 patients suggest the damage is not caused by the virus, but the body’s immune response to it. The spots were surrounded by T cells — signs of an immune response. THURSDAY, Dec. Researchers from the U.S. © 2020 HealthDay.

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Broad Institute

JULY 26, 2022

Researchers decipher how a gut bacterium influences immunity By Corie Lok July 26, 2022 Breadcrumb Home News Researchers decipher how a gut bacterium influences immunity Study finds a molecule made by the bacterium that helps moderate immune responses. It gets its name from the intestinal mucus it breaks down.

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The Pharma Data

JANUARY 9, 2021

Centers for Disease Control and Prevention, if you have a severe allergic reaction after the first shot, you should not get the second shot. Patients and doctors should balance the risks and benefits of vaccination. But such patients should be warned of the possibility that they will have a lower immune response.

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The Pharma Data

JUNE 30, 2021

For their remarkable scientific contributions, doctoral student Julia Klaus, Zurich University VetSuisse Faculty, and Dr Yasmin Parr from the MRC-University of Glasgow, Centre for Virus Research, have received the 2021 ABCD Young Scientist Award. References. For more information, please visit www.abcdcatsvets.org.

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Codon

AUGUST 27, 2024

Doctors in training are told that when they hear hoofbeats, they should think horses, not zebras; rare diseases are the exception, not the rule. Sometimes, though, novel diseases do emerge, and as COVID-19 demonstrated, they can surprise us. This is the third essay of four in our pandemic mini-issue.

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Codon

JULY 14, 2024

In 1940, Charles Drew—the first African-American researcher to earn a doctor of medical science degree at Columbia University—developed an ingenious method for separating and storing plasma , the liquid part of blood that contains essential proteins that promote clotting and regulate blood pressure. In the U.S.,

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The Pharma Data

NOVEMBER 12, 2020

Looking at tissue samples from 83 patients, the researchers found that those with advanced-stage cancer carried more microbes than patients in the early stage of disease. They also showed signs of an inflammatory immune response that, based on past research, may worsen lung cancer patients’ outlook. © 2020 HealthDay.

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The Pharma Data

DECEMBER 9, 2020

Some problems, she said, are related to an overactive immune response — such as Guillain-Barre syndrome, where the immune system attacks the body’s nerves. In other cases, Anand said, complications arise simply because a patient is critically ill in the hospital, and sometimes on a ventilator.

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Olympian Clinical Research

NOVEMBER 9, 2022

Although this disease is estimated to affect less than 50,000 Americans, it may be life-threatening, especially for people who are already in poor health. Neurological conditions, such as Parkinson’s disease or epilepsy. To diagnose bullous pemphigoid, your doctor may order a blood test and take a skin biopsy.

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The Pharma Data

NOVEMBER 24, 2020

Centers for Disease Control and Prevention stressed that Americans who get a shot shouldn’t be surprised if they feel under the weather for a few days afterwards. “These are immune responses, so if you feel something after vaccination, you should expect to feel that. Earlier Thursday, the U.S.

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NIH Director's Blog: Drug Development

DECEMBER 15, 2020

For doctors treating people with COVID-19, the website also provides a collection of useful information, including details on how to connect patients to ongoing clinical trials and other opportunities to combat COVID-19. Check out Combat COVID, where you’ll be directed to information about how to donate blood plasma.

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The Pharma Data

DECEMBER 29, 2020

Experts believe brain-related effects may be tied to the body’s immune response to the virus and possibly to vascular problems or surges of inflammation caused by the disease. ” Some patients needed weeks in the hospital before doctors could find a medication that worked.

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The Pharma Data

APRIL 22, 2023

It can work well, but we also want to trigger the immune system’s ability to remove the virus, which can be done through opsonizing antibodies that mark the virus so it can be eliminated,” explains Pontus Nordenfelt, associate professor and researcher in infectious medicine who led the study, published in PNAS.

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Codon

NOVEMBER 3, 2024

Physicians working in the early 20th century had little choice but to treat the world’s most rampant infectious disease with methods such as these. But even now, more than a century later, TB remains the deadliest infectious disease on Earth, killing about 1.2 million people every year. tuberculosis.

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Codon

FEBRUARY 13, 2024

alone, according to the Centers for Disease Control and Prevention. Such contaminants could have the same toxic effects as the bacterial infection, or provoke a severe immune response in the patient, and therefore the phage mixtures must go through extensive purification and testing procedures.

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Broad Institute

DECEMBER 6, 2023

The immune system can carry out many biological processes, from killing viruses to fighting cancer, thanks in large part to approximately 100 key cell-signaling proteins called cytokines, which instruct immune cells what to do. The reference, called the Immune Dictionary , appears today in Nature.

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Codon

JULY 27, 2023

CNGA3-achromatopsia is a hereditary disease that causes people to see in shades of gray. Their cone cells, which are responsible for color vision, don’t work like normal. There’s a TV show where a bunch of doctors are walking through a hospital corridor. a lower risk of immune responses. From Sulis D.B.

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Codon

JULY 27, 2023

CNGA3-achromatopsia is a hereditary disease that causes people to see in shades of gray. Their cone cells, which are responsible for color vision, don’t work like normal. There’s a TV show where a bunch of doctors are walking through a hospital corridor. a lower risk of immune responses. From Sulis D.B.

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Therapies RNA DNA Engineering 52

Codon

DECEMBER 12, 2024

7 During the few years that thalidomide was available on the market — and before Australian doctor William McBride warned of its consequences in a letter published in The Lancet in 1961 — it affected more than 10,000 babies, killing about half of them within months after birth. Not all pathogens spread quickly.

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The Pharma Data

MARCH 16, 2021

PsA can be a chronically painful and debilitating disease, and many PsA patients are still searching for enduring relief of their symptoms,” said Philip J. Vice President, Rheumatology Disease Area Leader, Janssen Research & Development, LLC. 1,2 TREMFYA is the first and only IL-23 inhibitor therapy approved in the U.S.

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The Pharma Data

JANUARY 4, 2021

CITYSCAPE provides the first evidence that targeting both immune inhibitory receptors, TIGIT and PD-L1, may enhance anti-tumor activity by potentially amplifying the immune response. “We Co-primary endpoints are overall response rate and progression-free survival. About the CITYSCAPE study. About tiragolumab.

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The Pharma Data

JANUARY 21, 2021

Doctors need better tools to evaluate the status of COVID-19 patients as early as possible because many of the treatments—such as monoclonal antibodies—are in short supply, and we know that some patients will get better without intensive treatments,” said co-senior author Andrew E. There’s so much we still don’t understand about this disease.

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Broad Institute

NOVEMBER 6, 2024

By Leah Eisenstadt November 6, 2024 Credit: Ricardo Job-Reese, Broad Communications Despite being one of the rarer complications from immune checkpoint inhibitors, myocarditis is the most deadly. Our results provide a more detailed picture of what’s happening in the heart and suggest intriguing new ways forward to improve patient care.”

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Broad Institute

NOVEMBER 6, 2024

We don’t have good therapeutic solutions and we often have to stop the antitumor therapy or give large amounts of steroids that will also shut down the very immune response that’s fighting the cancer. The longer patients wait to inform their doctor, the more complex it can become. How did you go about launching this effort?

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Codon

OCTOBER 27, 2024

The Most Deadly Infectious Disease “Each successive episode of bleeding left him weaker than before,” wrote Mary Doria Russell of Doc Holliday, the gunslinging gambler, in her eponymous book, Doc. .’ ” Doc suffered from tuberculosis, or TB, a bacterial disease caused by Mycobacterium tuberculosis.

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