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With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks

Broad Institute

They found significant associations between the thinning of different retinal layers and increased risk of developing ocular, cardiac, pulmonary, metabolic, and neuropsychiatric diseases and identified genes that are associated with retinal layer thickness. Their findings are published in Science Translational Medicine. “We

Disease 124
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Simple test for flu could improve diagnosis and surveillance

Broad Institute

The test, developed by a team from the Broad Institute of MIT and Harvard and Princeton University, and supported by the US Centers for Disease Control and Prevention, uses CRISPR to distinguish between the two main types of seasonal flu, influenza A and B, as well as seasonal flu subtypes H1N1 and H3N2. The Journal of Molecular Diagnostics.

Virus 144
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Zebrafish for Disease Modeling and Drug Screening in Pediatric Cancers

biobide

Pediatric cancers exhibit differences at the genetic level compared to the same form of adult disease, which may influence the selected treatment. This New Alternative Model (NAM) provides a platform for High-Content Screening through disease modeling through the transplantation of primary patient tumors into immunocompromised lines.

Disease 59
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#WhyIScience Q&A: A process development lead returns to her research roots

Broad Institute

By Andrea Tamayo May 30, 2023 Credit: Allison Dougherty, Broad Communications Isabella Teixeira-Soldano studies single cells to better understand disease progression. When I went to school, I was set on becoming a doctor. I told him I was struggling with my classes and that I didn’t think I'd make it to medical school.

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A close research partnership with African scientists helps solve the mystery of malaria-like illnesses

Broad Institute

By Claire Hendershot March 8, 2024 Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health via U.S. First author Zoë Levine is an MD-PhD candidate at Harvard Medical School and graduate student in the lab of Pardis Sabeti at the Broad.

Research 111
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To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives

Broad Institute

They knew that discovering the genetic cause of her disorder would help them find other people like her, help get the condition formally recognized as a new disease, and help them better advocate for research into new treatments. This is the first human disease caused by loss of one copy of a lncRNA gene.

DNA 128
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Michael Trembley

Broad Institute

Scientist II Michael Trembley is a scientist II at the Precision Cardiology Laboratory (PCL) of the Broad Institute and Bayer, where his research is focused on discovering and validating novel therapeutic targets for heart disease. Trembley holds a Ph.D. in pharmacology from the University of Rochester.