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Advancements in upstream CLD for enhanced biotherapeutics production

Drug Discovery World

As the significance of large molecules continues to broaden across diverse modalities, emphasis on bispecific and multispecific antibodies to treat various disorders such as rheumatologic diseases, cancer, diabetes, anaemia, and infectious diseases becomes paramount.

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Meet the researcher: Dr Stephen Jones

Drug Discovery World

Gene editing is a fascinating area of research, as these tools could be used to cure disease or to build models for understanding diseases, but they’re also useful for engineering crops or designing diagnostic tools – there’s such a wide range of applications. DS: What’s been the highlight of your career so far?

Research 147
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Turning science into business: An optimised alternative to antibodies

Drug Discovery World

DS: What motivated you and Dr David Bunka, CTO, to create Aptamer and did you imagine you would one day be operating on such a global scale?    AT : We initially met at the University of Leeds, where David was a post-doctoral researcher studying aptamers, and I was completing my PhD.

Science 130
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Precision Medicine – it’s not just for oncology anymore

The Pharma Data

Researchers are also using sophisticated machine learning and artificial intelligence to illuminate predictive relationships from highly complex and multi-modal data, including clinical, molecular, and digital data. These analytical tools are giving teams a look at diseases at a digital pathology level. Source link.

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The democratisation of cell and gene therapy

Drug Discovery World

DNA purification “Plasmid DNA is an incredibly important part of molecular biology”, says Hummersone. He says: “What we are seeing from a molecular biology perspective is that the genetic material that we want to pack into viral vectors is becoming increasingly complicated.

Therapies 273
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How organoids can redefine pre-clinical research

Drug Target Review

Moreover, their intricate 3D structure and cellular diversity offer a more precise replication of specific structures and functions, making them promising candidates in disease modelling and drug testing. CRISPR engineering in organoids for gene repair and disease modelling. Human organoids in basic research and clinical applications.

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Mediating BRAF-mutant melanoma resistance

Drug Target Review

Her research focus is on epigenetic regulation of melanoma and other cancers as well as wound healing, ageing biology and the development of novel epigenetic therapies targeting cancers and skin diseases and she is the owner of 15 issued and pending patents relevant to her research.