Drug Discovery World

NOVEMBER 1, 2023

DDW’s Diana Spencer meets Dr Stephen Jones, Research Professor and Group Leader at the EMBL Partnership Institute for Genome Editing Technologies at Vilnius University’s Life Sciences Center. SJ: I lead a research group at the EMBL Partnership Institute in Vilnius, Lithuania. SJ: CRISPR is the obvious one.

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Drug Discovery World

NOVEMBER 7, 2022

A new study led by Medical Research Council-funded researchers from UCL has found that tailoring the analysis of whole genome sequencing to individual patients could double the diagnostic rates of rare diseases. . It also detected potential disease-causing variants in a further 3.9% Context . The study .

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Drug Discovery World

JUNE 12, 2023

At the American Association of Cancer Research’s Annual Meeting in Orlando, Florida, DDW’s Megan Thomas met with industry experts to learn more about their research and careers in the field of cancer research. It gives the history of the disease and it’s pretty amazing.

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Drugs.com

JANUARY 11, 2024

doctors are prescribing antifungal creams to patients with skin complaints at rates so high they could be contributing to the rise of drug-resistant infections, new research shows.These are "severe. THURSDAY, Jan. 11, 2024 -- U.S.

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Drug Discovery World

DECEMBER 14, 2022

The 2023 ELRIG Research & Innovation conference will take place on March 29-30. Next year’s R&I meeting will focus on cutting edge innovation, comprising the following four main sessions: Synthetic biology; Healthy ageing; Ultra-rare disease drug discovery and personalised therapies; The rise of AI driven drug discovery. .

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Drug Target Review

NOVEMBER 29, 2023

Our primary focus is to design and develop RNA therapies for liver diseases. Using humans as the model, we use an approach called deep phenotyping to explore the relationships between cells, genes, biological pathways and patterns of disease. Why are you focusing on liver disease? As a result, waiting lists continue to grow.

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Advarra

MARCH 10, 2023

Having a one in four chance of developing sickle cell disease (SCD) is uniquely, and overwhelmingly, familiar to the African American population. Considered a rare disease, research in finding better therapies – and possibly even a cure – for SCD may be competing for funding with conditions impacting broader populations.

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Drug Discovery World

SEPTEMBER 1, 2022

Scottish scientists are teaming up with researchers from Zambia to find new ways to diagnose and treat a condition which affects millions in Sub-Saharan Africa. . The researchers are working to optimise a prototype breath test built around a process known as isotope ratio infrared spectrometry. Breath test key to diagnosis.

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Drug Discovery World

DECEMBER 18, 2023

However, this robust system can become alarmingly vulnerable when confronted with debilitating conditions like Alzheimer’s, cancer, and cardiovascular diseases. They mark a significant shift in clinical research, utilising technology to capture real-time patient data. Digital biomarkers could be the cornerstone of this evolution.

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Broad Institute

MARCH 8, 2024

By Claire Hendershot March 8, 2024 Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health via U.S. There are a lot of patients that they couldn’t treat unless it was malaria or a small host of other diseases. The bacteria causes infections with malaria-like symptoms.

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Drug Discovery World

JULY 29, 2022

From immunity to metabolism to mental health, it seems like the gut microbiome has been linked to every aspect of human health and disease. A team led by researchers at HMS and the Broad has just accomplished the rare feat of connecting those dots for one important gut bacterium. Study after study had suggested that A. New doors open.

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biobide

FEBRUARY 2, 2024

Pediatric cancers exhibit differences at the genetic level compared to the same form of adult disease, which may influence the selected treatment. How can research boost the discovery of specific therapies for childhood and adolescent cancers? This treatment was developed by performing a chemical screening on zebrafish.

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Drug Discovery World

MARCH 16, 2023

For example, in patients with autoimmune diseases who suffer from uncontrolled T cell activation. In the study, funded by Cancer Research UK and published in Nature , the mice fed diets containing high doses of sucralose were less able to activate T cells in response to cancer or infection.

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Broad Institute

FEBRUARY 8, 2024

Researchers uncover genetic factors for severe Lassa fever By Allessandra DiCorato February 8, 2024 Breadcrumb Home Researchers uncover genetic factors for severe Lassa fever New findings from an international collaboration pave the way for studies of highly infectious diseases in Africa such as Ebola.

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Drug Target Review

SEPTEMBER 22, 2023

Organoid technologies are becoming an invaluable solution for preclinical research, with the ability to augment the development of personalised medicine, drug discovery and gene therapies. The derived drug was given to both patients, to which researchers report the patients saw significant improvement.

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Advarra

JUNE 27, 2023

Clinical trials are studies involving human volunteers to research ways to prevent, detect, and treat various medical conditions. This article explores how the clinical research phases protect study volunteers from harm and ensure new drugs and therapies are developed effectively.

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SCIENMAG: Medicine & Health

JUNE 16, 2023

In humans, neurogenesis lasts particularly long compared with other species, explains Khadijeh Shabani, a post-doctoral researcher […] It is a complex process with finely tuned mechanisms. “In

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The Pharma Data

AUGUST 22, 2021

In the early days of the COVID-19 pandemic, doctors in Wuhan noticed something surprising. “There’s often a phenomenon that doctors report anecdotally, or that’s mentioned in passing in a particular research paper, and that provides a clue – a hook,” he said. The next challenge was to figure out why.

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Olympian Clinical Research

SEPTEMBER 16, 2022

million Americans were living with Alzheimer’s disease in 2021, according to the Centers for Disease Control and Prevention (CDC). Alzheimer’s disease is the seventh leading cause of death in the United States and is a devastating disease that can rob people of their memories and lives. Eating a Healthy Diet.

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The Pharma Data

DECEMBER 10, 2020

Dr. Pirozzi received a Doctorate of Medicine from Università Campus Bio-Medico di Roma in Italy, a Doctorate of Philosophy in Immunology from Sapienza Università di Roma in Italy, a Post-Doctorate degree in Immunology from the Institut Pasteur in Paris, France, and business training at the London Business School, UK.

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SCIENMAG: Medicine & Health

NOVEMBER 27, 2023

27, 2023 – Common neuropsychiatric symptoms that doctors see in Alzheimer’s disease patients originate from brain inflammation rather than amyloid and tau proteins, report University of Pittsburgh School of Medicine researchers today in JAMA Network Open. PITTSBURGH, Nov. Credit: UPMC PITTSBURGH, Nov.

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Drug Discovery World

JULY 29, 2022

Australian researchers based may be a step closer to preventing Type 1 diabetes after identifying a crucial protein that could prevent the autoimmune disease from taking hold. The findings have been replicated by an independent research group at Novo Nordisk in the United States.

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Broad Institute

JUNE 18, 2024

Now researchers have developed a low-cost paper strip test that could allow more patients to find out which type of flu they have and get the right treatment. Myhrvold, who is currently an assistant professor at Princeton University, was a postdoctoral researcher in Sabeti’s lab when the study began.

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Drug Discovery World

JUNE 21, 2024

The ALPHA3 trial will screen patients who are likely to relapse after first line treatment for enrolment in the trial by using the Foresight Clarity Investigational Use Only (IUO) measurable residual disease (MRD) test.

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Antidote

JANUARY 29, 2024

Not only will patients be able to gain access to potential new treatments, but they will also be directly contributing to research that can save lives — something that Jamie Troil Goldfarb has experienced firsthand. Jamie received a diagnosis of stage IV melanoma in 2011, only 11 weeks after giving birth to her child.

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Drug Target Review

JANUARY 12, 2024

How does the integration of Real-World Data (RWD) with genomic biomarker data contribute to a more comprehensive understanding of disease progression and treatment response? Biomarker information is also useful for tracking progression of the disease and treatment response. Most drugs do not work in all people.

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The Pharma Data

JULY 22, 2021

NOTE: ADUHELM TM (aducanumab-avwa)injection 100 mg/mL solutionis indicated for the treatment of Alzheimer’s disease. Treatment with ADUHELM should be initiated in patients with mild cognitive impairment or mild dementia stage of disease, the population in which treatment was initiated in clinical trials. Biogen Inc.

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Alta Sciences

JUNE 12, 2024

Before becoming a study director, Ashley held the position of Research Technician II. As Staff Research Associate II at the University of California, Davis, she performed rodent survival surgeries, conducted electrophysiological recordings, managed lab operations, and analyzed data for scientific manuscripts.

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Elrig

APRIL 30, 2024

Biophysical sensors in studies on pharmacologically-dark G protein-coupled receptors | Insights from Pawel Kozielewicz The class F (Frizzled, FZD) GPCRs are important in development and signalling and are implicated in a diverse range of diseases. I had my first post-doctoral stay in the lab of Prof. In August 2017, I joined Prof.

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Drug Discovery Today

JANUARY 13, 2021

Mission: Cure is a coalition of patients, doctors, researchers and entrepreneurs who are committed to advancing new therapies and cures for currently untreatable diseases. Their primary disease focus is on chronic pancreatitis, a rare inflammatory condition that affects over a million people across the globe.

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Conversations in Drug Development Trends

FEBRUARY 22, 2023

Rare Disease Day on February 28th is a chance for rare disease communities to come together as one and join in conversation with stakeholders searching for treatments, raising money to support research, and changing the way healthcare and governments interact with patients. In my case, my daughter Iris has GM1 gangliosidosis.

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The Pharma Data

JUNE 1, 2022

has been appointed Senior Vice President and Head of the Company’s Vaccine Research & Development (R&D) organization effective August 1, succeeding Kathrin U. Chief Scientific Officer and President, Worldwide Research, Development and Medical of Pfizer. “I (NYSE: PFE) today announced that Annaliesa Anderson, Ph.D.,

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Drug Discovery World

MARCH 20, 2023

This biosensor has the potential to aid the development of new treatments for DNA damage-related diseases by revealing how our bodies repair damaged DNA. In a 2023 study, researchers describe a fluorescence resonance energy transfer (FRET) biosensor that can detect DSBs in real time and provide time- and location-based information on yH2AX.

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Broad Institute

JULY 26, 2022

Researchers decipher how a gut bacterium influences immunity By Corie Lok July 26, 2022 Breadcrumb Home News Researchers decipher how a gut bacterium influences immunity Study finds a molecule made by the bacterium that helps moderate immune responses. Study after study had suggested that A. muciniphila ’s cell membrane.

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The Pharma Data

JANUARY 15, 2021

13 in the New England Journal of Medicine , involved patients with high blood pressure in the lungs caused by interstitial lung disease (ILD). It can have a range of causes, from smoking, to occupational exposure to toxins like asbestos, as well as autoimmune diseases like rheumatoid arthritis. The study, published online Jan.

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The Pharma Data

OCTOBER 23, 2020

23, 2020 — High levels of a protein that lubricates the knee joint may actually be a harbinger of impending joint disease, a surprising animal study suggests. “We know that if a person or animal doesn’t make that protein, they will develop devastating joint disease affecting all the major weight-bearing joints.”

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Drug Discovery World

OCTOBER 18, 2023

Sara Donnelly, Director of Research Planning and Business Development at PhoenixBio USA explores why the right pre-clinical model is essential for teams wanting to advance adeno-associated virus vector-based gene therapies. Adeno-associated virus (AAV) vector-based gene therapies hold exceptional promise across a range of disease areas.

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