Drug Discovery World

DECEMBER 14, 2022

The 2023 ELRIG Research & Innovation conference will take place on March 29-30. Next year’s R&I meeting will focus on cutting edge innovation, comprising the following four main sessions: Synthetic biology; Healthy ageing; Ultra-rare disease drug discovery and personalised therapies; The rise of AI driven drug discovery. .

Research 130

Research Doctors Science Therapies 130

Drug Discovery World

SEPTEMBER 5, 2022

The discovery was made by researchers at Washington University School of Medicine in St Louis, Grenoble Alpes University in Grenoble in France, and The University of Texas MD Anderson Cancer Center in Houston. A pathway to better therapies. One of the challenges we will face is convincing doctors to go back to an old drug.

Therapies 130

Therapies Treatment DNA Clinical Trials 130

Advarra

MARCH 10, 2023

Having a one in four chance of developing sickle cell disease (SCD) is uniquely, and overwhelmingly, familiar to the African American population. Considered a rare disease, research in finding better therapies – and possibly even a cure – for SCD may be competing for funding with conditions impacting broader populations.

Disease 98

Disease Clinical Trials Doctors Trials 98

biobide

FEBRUARY 2, 2024

Pediatric cancers exhibit differences at the genetic level compared to the same form of adult disease, which may influence the selected treatment. Children and adolescents lack robust preclinical models to replicate the pathologies and provide precise and targeted therapies.

Disease 59

Disease Medical Schools Pharma Companies Clinical Trials 59

Drug Discovery World

JULY 29, 2022

From immunity to metabolism to mental health, it seems like the gut microbiome has been linked to every aspect of human health and disease. A team led by researchers at HMS and the Broad has just accomplished the rare feat of connecting those dots for one important gut bacterium. Study after study had suggested that A. New doors open.

Research 130

Research Immune Response Medical Schools Disease 130

Drug Target Review

SEPTEMBER 1, 2023

Could you explain the fundamental distinction between autologous and allogeneic cell therapies and how they differ in terms of cell sourcing and application? Autologous immune cell therapy involves the grafting of a patient’s own immune cells. Then, cells are infused back to that same patient.” There are pros and cons to each.

Therapies 105

Therapies Engineering Production Clinical Trials 105

Drug Target Review

SEPTEMBER 22, 2023

Organoid technologies are becoming an invaluable solution for preclinical research, with the ability to augment the development of personalised medicine, drug discovery and gene therapies. The derived drug was given to both patients, to which researchers report the patients saw significant improvement.

Clinical Research 116

Clinical Research Research Drug Development Molecular Biology 116

Advarra

JUNE 27, 2023

Clinical trials are studies involving human volunteers to research ways to prevent, detect, and treat various medical conditions. A clinical trial investigating a drug or therapy is typically divided into four phases: Phase I, Phase II, Phase III, and Phase IV.

Clinical Research 52

Clinical Research Research Clinical Trials Trials 52

Drug Discovery World

AUGUST 14, 2024

Even with an approved therapy or a late-stage clinical trial, it’s still not a given that patients or doctors will have access to comprehensive and cost-effective genetic testing. Increasingly, companies are testing multiple different assets in the same disease but with different genetic targets, for example, in breast cancer.

Clinical Trials 147

Clinical Trials Trials Disease Therapies 147

Broad Institute

OCTOBER 3, 2024

The findings point to factors involved in how neurons communicate and fire, suggesting potential targets for new therapies. In the future, the results could also help doctors tailor treatments to a patient’s genome. Epilepsy is one of the most common neurological disorders.

DNA 72

DNA Doctors Treatment Disease 72

FDA Law Blog: Drug Discovery

MARCH 13, 2023

Knowing they could not hold PFDD meetings for every disease ( there are over 10,000 rare diseases alone ), they decided to turn PFDD meetings over to disease advocacy organizations, calling them Externally-Led Patient Focused Drug Development (EL-PFDD) meetings. There have been challenges in gene therapy development.

Therapies 98

Therapies FDA Trials Clinical Trials 98

Drug Target Review

JANUARY 12, 2024

How does the integration of Real-World Data (RWD) with genomic biomarker data contribute to a more comprehensive understanding of disease progression and treatment response? This one size fits all approach to drug prescribing still pervades in mostly all therapy areas except oncology. Most drugs do not work in all people.

Doctors 111

Doctors Clinical Trials Treatment Therapies 111

The Pharma Data

AUGUST 22, 2021

In the early days of the COVID-19 pandemic, doctors in Wuhan noticed something surprising. “There’s often a phenomenon that doctors report anecdotally, or that’s mentioned in passing in a particular research paper, and that provides a clue – a hook,” he said. The next challenge was to figure out why.

Doctors 52

Doctors Drugs Immune Response Virus 52

Drug Target Review

OCTOBER 1, 2024

Since I was a child, I always wanted to be a doctor. From a human point of view, I have always considered doctors’ work as a sort of mission for the good of others. Being a doctor means giving courage and hope day in, day out to those experiencing illness.

Doctors 64

Doctors Therapies Science Pharma Companies 64

The Pharma Data

DECEMBER 10, 2020

Dr. Pirozzi received a Doctorate of Medicine from Università Campus Bio-Medico di Roma in Italy, a Doctorate of Philosophy in Immunology from Sapienza Università di Roma in Italy, a Post-Doctorate degree in Immunology from the Institut Pasteur in Paris, France, and business training at the London Business School, UK.

Disease 52

Disease Research Doctors Clinical Development 52

Drug Discovery Today

JANUARY 13, 2021

Mission: Cure is a coalition of patients, doctors, researchers and entrepreneurs who are committed to advancing new therapies and cures for currently untreatable diseases. Their primary disease focus is on chronic pancreatitis, a rare inflammatory condition that affects over a million people across the globe.

Treatment 113

Treatment Doctors Disease Therapies 113

PLOS: DNA Science

OCTOBER 12, 2023

In the final chapter of my 2012 book The Forever Fix: Gene Therapy and the Boy Who Saved It , I predicted that the technology would soon expand well beyond the rare disease world. Gene therapy clearly hasn’t had a major impact on health care, offering extremely expensive treatments for a few individuals with rare diseases.

Therapies 69

Therapies Immune Response DNA Virus 69

PLOS: DNA Science

OCTOBER 3, 2024

One of the oldest and most successful immunotherapies is simpler: a tamed version of a classic vaccine, against the infectious disease tuberculosis (TB). A research team led by Rita Fior at the Champalimaud Centre for the Unknown, Lisbon, Portugal, figured out how BCG decimates cancer cells. The approach worked.

Vaccine 52

Vaccine Immune Response DNA Doctors 52

Drug Target Review

FEBRUARY 29, 2024

During my academic career, I had the opportunity to examine the underlying causes of neurodegenerative diseases like Parkinson’s disease and develop novel animal models to investigate potential disease-modifying therapeutics. AskBio) I continue to work to bring innovative gene therapies to patients in need.

Therapies 111

Therapies Disease Clinical Trials Science 111

The Pharma Data

JULY 22, 2021

NOTE: ADUHELM TM (aducanumab-avwa)injection 100 mg/mL solutionis indicated for the treatment of Alzheimer’s disease. Treatment with ADUHELM should be initiated in patients with mild cognitive impairment or mild dementia stage of disease, the population in which treatment was initiated in clinical trials.

Disease 52

Disease Research Clinical Trials FDA 52

Alta Sciences

JUNE 12, 2024

Before becoming a study director, Ashley held the position of Research Technician II. As Staff Research Associate II at the University of California, Davis, she performed rodent survival surgeries, conducted electrophysiological recordings, managed lab operations, and analyzed data for scientific manuscripts.

Doctors 98

Doctors International Research Science 98

KIF1A

AUGUST 20, 2024

So the pediatrician doctor requested the first cranial tomography, which also gave a normal result. Pauline is now 10 months old, undergoing physical and occupational therapy using the Cuevas method and is also having speech therapy sessions to help and strengthen the muscles involved in swallowing.

Doctors 52

Doctors Hospitals DNA Therapies 52

The Pharma Data

JANUARY 15, 2021

13 in the New England Journal of Medicine , involved patients with high blood pressure in the lungs caused by interstitial lung disease (ILD). It can have a range of causes, from smoking, to occupational exposure to toxins like asbestos, as well as autoimmune diseases like rheumatoid arthritis. The study, published online Jan.

Disease 52

Disease Doctors FDA Approval Trials 52

Drug Discovery World

APRIL 3, 2023

DS: What motivated you and Dr David Bunka, CTO, to create Aptamer and did you imagine you would one day be operating on such a global scale?    AT : We initially met at the University of Leeds, where David was a post-doctoral researcher studying aptamers, and I was completing my PhD. DS: The company now has clients across big pharma.

Science 130

Science Molecular Biology Therapies Disease 130

Drug Discovery World

JUNE 21, 2024

The ALPHA3 trial will screen patients who are likely to relapse after first line treatment for enrolment in the trial by using the Foresight Clarity Investigational Use Only (IUO) measurable residual disease (MRD) test.

Trials 147

Trials Compliance Clinical Trials Doctors 147

Drug Discovery World

NOVEMBER 13, 2023

Nipocalimab, according to Abouzahr, is currently the only FcRn being studied in all three segments of autoantibody-driven disease. She says: “At Janssen, we’re fortunate that we’re building on a leadership that we’ve created over the last couple of decades of treating immune-mediated diseases.

Engineering 147

Engineering Therapies Disease Treatment 147

The Pharma Data

NOVEMBER 20, 2020

20, 2020 — Hormone therapy can be a lifesaver for men with prostate cancer , but it also appears to put some at increased risk of heart problems, a new study reports. At the start of the study, 4 out of 5 men had two or more risk factors for heart disease , the study says. FRIDAY, Nov.

Therapies 52

Therapies Doctors Disease Hospitals 52

Drug Target Review

JANUARY 23, 2024

In April 2023, we saw the first randomised data applying an individualised vaccine in combination with checkpoint inhibition for resectable melanoma, demonstrating benefit in terms of time to disease recurrence. Espen integrates clinical and research expertise as Director of Medical Affairs.

Treatment 122

Treatment Immune Response Vaccine Therapies 122

The Pharma Data

JUNE 1, 2022

has been appointed Senior Vice President and Head of the Company’s Vaccine Research & Development (R&D) organization effective August 1, succeeding Kathrin U. Chief Scientific Officer and President, Worldwide Research, Development and Medical of Pfizer. “I (NYSE: PFE) today announced that Annaliesa Anderson, Ph.D.,

Vaccine 40

Vaccine Research Doctors Laboratories 40

PPD

MAY 18, 2023

For neurodegenerative disease research, the care partner, or caregiver, is equally important as the person with dementia. The care partners are the decision-makers for their loved ones with neurodegenerative disorders, handling everything from daily routines and medication management to doctor visits.

Clinical Trials 86

Clinical Trials Trials Clinical Research Doctors 86

Drug Discovery World

JANUARY 22, 2024

For the patient as well as for doctors, this means creating more time to make decisions, as the company believes: “Patients – and their quality of life – shouldn’t have to wait for a broken system to provide an answer six months too late.

Vaccine 147

Vaccine Immune Response Engineering Virus 147

Broad Institute

JULY 26, 2022

Researchers decipher how a gut bacterium influences immunity By Corie Lok July 26, 2022 Breadcrumb Home News Researchers decipher how a gut bacterium influences immunity Study finds a molecule made by the bacterium that helps moderate immune responses. Study after study had suggested that A. muciniphila ’s cell membrane.

Research 52

Research Immune Response Medical Schools Disease 52

Conversations in Drug Development Trends

FEBRUARY 22, 2023

Rare Disease Day on February 28th is a chance for rare disease communities to come together as one and join in conversation with stakeholders searching for treatments, raising money to support research, and changing the way healthcare and governments interact with patients. In my case, my daughter Iris has GM1 gangliosidosis.

Disease 52

Disease Clinical Trials Trials Treatment 52

KIF1A

JUNE 4, 2024

Hundreds of doctor appointments and uncountable exams, second and third opinions, but nothing made sense. Something that seemed so easy, became something very hard to finally do, there’s very little information about genetic disorders in Chile, so it was hard to find consensus between Elena’s doctors on which was the right test.

Doctors 52

Doctors Therapies Treatment Laboratories 52

Drug Discovery World

FEBRUARY 1, 2023

Michael Sassano , CEO at SOMAÍ Pharmaceuticals looks at what’s needed throughout Europe to help increase access to medicinal cannabis and the current state of pharmaceutical research in this area. But for this market to become a reality, we need much more research into cannabis products and potential indications.

Clinical Trials 130

Clinical Trials Trials Pharmaceutical Companies Doctors 130

On Medicine

FEBRUARY 26, 2023

Behçet’s disease is a rare multisystem vasculitic disorder that can affect any of the blood vessels of the body; signs and symptoms are diverse among individuals and range in severity, but often present as recurrent oral aphthous ulcers, genital ulcers, or as complications involving the eyes.

Disease 40

Disease Nurses Treatment Doctors 40

Drug Target Review

DECEMBER 28, 2023

In most cancers, the tumour evolves by acquiring mutations that confer growth advantages or resistance to therapies. However, if the therapy targets only the subclonal (branch) mutations, this will result in the mere ‘pruning’ of specific branches rather than elimination of the whole cancer.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105