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Mathematical model can speed up Alzheimer’s drug development

Drug Discovery World

Researchers have created a mathematical model that can accurately depict Alzheimer’s disease progression in individual patients, paving the way for personalised treatment and faster development of therapies.

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Vicore initiates clinical proof-of-concept study of endothelial dysfunction 

Drug Discovery World

Vicore Pharma, a Swedish clinical-stage pharmaceutical company unlocking the potential of angiotensin II type 2 receptor agonists (ATRAGs), has dosed its first patient with C21 in a clinical study of endothelial dysfunction. Vicore Pharma states that results from the trial are expected in Q4, 2023.

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An Evolving Regulatory Environment for Rare and Orphan Diseases

Advarra

A rare, or orphan, disease by definition affects a small percentage of the population — fewer than 200,000 people in the U.S. But the numbers add up, and taken together, rare diseases impact an estimated 30 million Americans. Food and Drug Administration (FDA) approval. The FDA Since 1983.

Disease 52
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International Women’s Day: Female life science leaders

Drug Discovery World

Dr Thomas has a background in biochemistry research at Leicester, Cambridge, and Glaxo, after which she has had 25 years of pharmaceutical drug discovery and development experience from large Pharma (GSK) and SMEs. Anti-ageing science therefore has huge value. I owe so much to Franklin and many others.”

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Advanced 3D cell-based technologies

Drug Target Review

The chips can be modelled with primary cells, IPS derived stem cells or patient derived cells and potentiates to unlock molecular mechanisms that drive the disease pathophysiology, holding a greater promise. These guidelines drive the legitimacy of the models towards regulatory approval.