Drug Discovery World

MAY 21, 2024

This remarkable progress in antibody modalities for disease treatment is a testament to the effectiveness of these methods, and they remain key for many use cases. These targets, along with many others, are universally deemed as ‘difficult-to-drug’ targets.

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Drug Discovery World

NOVEMBER 3, 2023

News round-up for 30 October – 3 November by DDW Editor Reece Armstrong My news highlights this week feature a variety of exciting clinical trial results and launches that are examining therapies for much-needed disease areas, new drug approvals and even a space mission with a pharma twist.

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Drug Discovery World

JUNE 9, 2023

There has been some interesting news related to clinical trials this week, with the announcement that the FDA has published draft guidance to modernise the design and conduct of studies, and the failure of Bellerophon Therapeutics’ Phase III study in fibrotic Interstitial Lung Disease.

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Clinical Trials FDA Trials Drugs 130

Drug Discovery World

FEBRUARY 10, 2023

Clinical drug trials have made the headlines this week, as it was revealed that breast cancer still tops the bill for number of clinical studies and the shortcomings in current methods to ensure representation of patient populations in trials were exposed.

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Conversations in Drug Development Trends

NOVEMBER 3, 2022

This plan, designed to help make clinical trial enrollment more representative, stands to support diversity, equity and inclusion (DEI) initiatives in R&D — a sector that certainly needs more attention across all clinical trials. But in rare disease trials, that can be challenging given the barriers inherent in U.S.

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Advarra

AUGUST 16, 2022

A rare, or orphan, disease by definition affects a small percentage of the population — fewer than 200,000 people in the U.S. But the numbers add up, and taken together, rare diseases impact an estimated 30 million Americans. Before 1983, only 38 orphan drugs had received U.S. Food and Drug Administration (FDA) approval.

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Disease Clinical Trials FDA Approval FDA 52

Drug Discovery World

MAY 3, 2023

Endothelial dysfunction Endothelial dysfunction is characterised by a proinflammatory and prothrombotic state with impaired microvascular blood flow, and it is a vascular hallmark of several common diseases. Treating endothelial dysfunction could be a major breakthrough in cardiovascular disease”.

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FDA Approval Trials Pharmaceutical Companies Disease 130

The Pharma Data

NOVEMBER 10, 2020

Biomarkers will be critical to developing precision medicine for Alzheimer’s disease. Although a few are out there, phosphorylated tau (P-tau) may enable even earlier and more accurate detection, according to Eli Lilly-associated researchers speaking at the Clinical Trials on Alzheimer’s Disease (CTAD) virtual conference in early November.

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Disease Clinical Trials Trials Research 52

Drug Discovery World

FEBRUARY 20, 2023

Breast cancer retained its position as the most-studied disease area in clinical trials in 2022, according to a recent report by analytics company Phesi. Here, we take a look at the top four disease areas and some of the key developments in 2022. Capivasertib could offer a completely new treatment option for these patients.

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Trials Drug Trials Disease Clinical Trials 130

Codon

JANUARY 21, 2024

Today, refined versions of these human challenge studies have become standard practice in testing vaccines for vector-borne diseases (e.g., yellow fever, malaria, and dengue), evaluating new drugs or treatments, and studying pathogenesis, the process by which a disease develops.

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Vaccine Trials Disease Virus 132

Advarra

JUNE 27, 2023

Most modern medicines were developed from clinical trials , and clinical trials remain essential for drug development. Without clinical studies, our global understanding of medicine would likely stagnate, and novel treatments would cease to emerge.

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Clinical Research Research Clinical Trials Trials 52

Drug Discovery World

JULY 20, 2023

What are benefits of drug repurposing and why do clinical drug trials so often fail? Diana Spencer summarises the key messages from the ‘Drug Repurposing: Challenges and Opportunities’ Symposium held at the 19th World Congress of Basic & Clinical Pharmacology (WCP) 2023.

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Drug Discovery World

OCTOBER 2, 2023

Artificial intelligence (AI) is rapidly taking hold in the healthcare sector 1 , including in medical imaging, where AI often targets screening, patient eligibility, detection and disease response (Figure 1). This can lead to generation of more objective endpoints that might lead to a better assessment of treatment efficacy.

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Clinical Trials Trials Treatment Drug Trials 147

The Open Targets Blog

OCTOBER 31, 2023

The goal of MTP is to integrate the FDA’s Relevant Molecular Target List and enrich the platform with pre-clinical paediatric cancer datasets containing somatic variation, gene expression, and gene fusion data to aid in identifying new paediatric cancer-specific drug targets. earlier this year.

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Bioinformatics Engineering FDA Clinical Trials 69

Drug Discovery World

MARCH 7, 2023

She has managed multinational projects for charities and not-for-profits to find new treatments for Malaria and led Innovate UK grants through to successful completion. Here at FAB our proprietary approach aims to overcome this fundamental challenge to human health as we work to discover and develop new drugs for age-associated diseases.”

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Agency IQ

MARCH 29, 2024

Andrews, Oxford, the British Medical Journal Medicine products pending European Commission decision following CHMP opinion Below are the drug or biologic products for which decisions are expected to occur within the next two months, according to AgencyIQ’s review of opinions from the EMA’s Committee for Medicinal Products for Human Use (CHMP).

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Drug Discovery World

JANUARY 17, 2024

With oncology accounting for a third of pharma’s product pipeline, significant challenges include fierce competition, high research and development costs over, 10-15 years for clinical development, and pressures to rapidly meet the demand for new treatments 2-4.

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DNA Clinical Trials RNA Treatment 147

The Pharma Data

AUGUST 16, 2020

A number of diseases manifest differently depending on skin tone, but too little attention is given to this in training, according to Dr Joseph Hartland, who is helping to lead changes at the University of Bristol Medical School. . Life-or-death signs. ” Experiments without consent.

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Drug Target Review

NOVEMBER 30, 2023

From an early age, I’ve been passionate about finding cures for difficult-to-treat diseases. I accepted and I’ve been CEO ever since; our goal, from the beginning, was to pioneer new ways to diagnose, treat and prevent neurodegenerative diseases. That’s missing the point – we have learned how to slow the disease.

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Drug Discovery World

OCTOBER 6, 2022

Precision medicine promises a paradigm shift to confidently match the right patients to the right treatment at the right time. In the cancer space alone over the last five years, clinical trials have increased 500% for new drugs and new drug combinations. Through testing and diagnostics.

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Clinical Trials Immune Response Therapies Trials 130

Agency IQ

MAY 3, 2024

Start Date End Date Event Event Type Organization 4/30/2024 4/30/2024 Seminar No. Start Date End Date Event Event Type Organization 4/30/2024 4/30/2024 Seminar No. and 2 mg [EMA] Product-specific bioequivalence guidance 6/30/2024 Pharmeuropa 36.2

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Regulations Clinical Trials Production Biosimilars 40

The Pharma Data

MAY 17, 2021

Regeneron resumes enrollment in lymphoma drug trials ( Reuters ). Incyte’s vitiligo treatment meets main goal in late-stage trial ( Reuters ). Desperate for treatment, Covid ‘long haulers’ push for 9/11-style health registry ( Politico ). BioPharmaDive ).

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