Chemical Biology and Drug Design

MAY 11, 2023

The figure depicts the neuroprotective role of crocin in Parkinson's disease. Abstract Parkinson's disease is among the most common forms of neurodegenerative illness, with present treatment being primarily symptomatic and frequently coming with substantial adverse effects.

Disease 100

Disease Research Clinical Trials Treatment 100

SCIENMAG: Medicine & Health

JANUARY 12, 2024

12, 2024) — The University of Kentucky will mark a decade of raising awareness and continuing its effort to warn women about the dangers of heart disease with the annual Healthy Hearts for Women Symposium. LEXINGTON, Ky. Credit: Peera_Sathawirawong, iStock/Getty Images Plus LEXINGTON, Ky.

Disease 82

Disease 82

Chemical Biology and Drug Design

FEBRUARY 13, 2024

Alzheimer's disease (AD) is a common age-related neurodegenerative brain disorder characterized by the impairment in memory and other cognitive functions. Abstract Alzheimer's disease (AD) is a common age-related neurodegenerative brain disorder characterized by the impairment in memory and other cognitive functions.

Disease 100

Disease Treatment Therapies Research 100

Drug Target Review

JULY 7, 2023

Approximately three percent of the global population — 240 million people — experience autoantibody diseases, which occur when one’s own body attacks critical organs and tissues. This can create an abnormal immune response that attacks the cells of our bodies and contributes to the development of autoantibody diseases.

Disease 98

Disease Immune Response Therapies Treatment 98

SCIENMAG: Medicine & Health

AUGUST 28, 2023

military veterans with coronary artery disease, suboptimal lipid-lowering therapy was prevalent in the clinical setting. Optimization of statin therapy was projected to produce clinically relevant reductions in the risks of death and cardiovascular events. About The Study: In this study of 111,000 U.S.

Therapies 84

Therapies Disease 84

Science Daily: Pharmacology News

JULY 5, 2023

Researchers have developed a soft, flexible, wireless device to monitor and treat heart disease and dysfunction in the days, weeks or months following traumatic heart-related events. And, after the device is no longer needed, it harmlessly dissolves inside the body, bypassing the need for extraction.

Disease 77

Disease Research 77

Fierce BioTech

SEPTEMBER 20, 2023

In this podcast interview, Dan Fisher, managing director and practice lead for IPM.ai, explains the use of artificial intelligence for stitching together key medical events that may happen over a r | IPM.ai helps brands assess a unique patient population, accelerate clinical trial recruitment, and optimize commercial outcomes

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Clinical Trials Disease Trials 105

Drug Channels

APRIL 4, 2022

Rare Disease Innovation & Partnering Summit. Hybrid Event May 17-19, 2022 | Boston, MA www.informaconnect.com/rare. Don’t miss the Rare Disease Innovation & Partnering Summit, coming up May 17-19, 2022 in Boston, MA. Visit www.informaconnect.com/rare for further details and to register. d/b/a Drug Channels Institute.

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Disease Therapies FDA Trials 77

Drug Discovery Today

JULY 29, 2022

Geneva-based event pledges five Swiss francs per visitor to support new drug development project

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Disease Research Drug Development Drugs 113

Broad Institute

JULY 6, 2023

The accuracy of these scores has improved for some diseases and groups of people, but they continue to fall short for those of non-European ancestry, mainly because the genetic datasets used to calculate these scores have largely come from people of European ancestry.

Disease 97

Disease DNA Hospitals Medical Schools 97

KIF1A

APRIL 13, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. In cases of hypoxic-ischemic encephalopathy (HIE), the developing child’s brain is damaged by an event of restricted bloodflow and loss of oxygen.

Disease 111

Disease Research Science 111

Drug Target Review

APRIL 11, 2024

Targeting pathways involved in SMC phenotypic modulation holds promise for developing novel therapeutic approaches for cardiovascular diseases. Can you explain the methodology used to investigate the genetic variants regulating extracellular matrix (ECM) secretion in SMCs, and predict proteins associated with vascular disease?

Disease 59

Disease Engineering Regulations Clinical Research 59

Advarra

FEBRUARY 22, 2024

Assessing and reporting adverse events (AEs) in clinical trials is critical to ensuring the study is as safe as possible and the participants have the most up to date information so they can decide whether to continue their participation in the research study. These responsibilities and reporting requirements are outlined in U.S. regulations.

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Clinical Trials FDA Drugs Research 52

Drug Target Review

SEPTEMBER 9, 2024

functions to reset the immune system and potentially provide remission for allergic diseases? In allergic diseases, APCs identify and present unknown antigens to the immune system. This can lead to inadequate long-term effectiveness with low rates of disease remission. They also require frequent administration.

Disease 64

Disease Immune Response Clinical Trials Treatment 64

Drugs.com

JUNE 13, 2024

THURSDAY, June 13, 2024 -- Climate change is harming the heart health of people around the world, a new review warns.Extreme temperatures, hurricanes and other dangerous weather events all contribute to an increased risk of heart disease and.

Disease 98

Disease 98

BMG Labtech

OCTOBER 30, 2023

Cardiovascular disease, a group of disorders of the heart and blood vessels, is the number one cause of death across the world. One disorder in particular, atherosclerotic vascular disease, a chronic inflammatory disease associated with the formation of arterial plaques, is considered the major cause of cardiovascular diseases.

Disease 52

Disease Cell Based Assays Research Drugs 52

Drug Target Review

JANUARY 2, 2024

We are studying the placement of organelles within cells and how they communicate to help better treat disease,” said Coskun. Scrutinising these distinctions aids scientists in comprehending cellular operations, thereby fostering enhanced therapeutic approaches for diverse diseases.

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RNA Immune Response Therapies Disease 128

Conversations in Drug Development Trends

AUGUST 29, 2024

By: Nathan Chadwick, Therapeutic Strategy Lead, Rare Disease Over the last few years in clinical trials, particularly within the rare disease community, a notable shift is underway, where patients and caregivers are taking the lead in reaching out to clinical trial sites rather than the other way around.

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Clinical Trials Trials Disease Drug Development 52

Conversations in Drug Development Trends

APRIL 5, 2024

For others, this rare day is aptly the day we honor rare disease communities. Observed annually on the last day of February since 2008, Rare Disease Day has grown into a global movement for raising awareness, promoting research, and advocating for improved access to rare disease treatments and support services.

Disease 52

Disease Clinical Trials Trials Treatment 52

KIF1A

JULY 15, 2023

Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. When the brain’s electrical activity changes enough to cause noticeable changes in behavior, we call that event a seizure. From Gschwind et al. 2023, Neuron.

Disease 98

Disease Treatment Research Therapies 98

SCIENMAG: Medicine & Health

FEBRUARY 21, 2024

Using intravascular imaging to guide stent implantation during percutaneous coronary intervention (PCI) in heart disease patients significantly improves survival and reduces adverse cardiovascular events compared to angiography-guided PCI alone, the most commonly used method.

Disease 83

Disease 83

Olympian Clinical Research

SEPTEMBER 16, 2022

million Americans were living with Alzheimer’s disease in 2021, according to the Centers for Disease Control and Prevention (CDC). Alzheimer’s disease is the seventh leading cause of death in the United States and is a devastating disease that can rob people of their memories and lives. Eating a Healthy Diet.

Disease 52

Disease Clinical Trials Clinical Research Trials 52

KIF1A

FEBRUARY 24, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. Read the Article Rare Roundup Rare Disease Day is this Thursday, February 29th!

Disease 111

Disease Research Treatment Science 111

ASPET

NOVEMBER 30, 2023

In this study, we evaluated the long-term efficacy of novel synthetic neurosteroids in preventing the development of chronic epilepsy and hyperexcitable ictal events in a rat OP model of SE. It significantly reduced the occurrence of epileptic biomarkers of HFOs and interictal spikes, indicating potential disease-modifying activity.

Disease 100

Disease Therapies Treatment 100

The Premier Consulting Blog

OCTOBER 11, 2022

Clinical trials for ultra-rare diseases can be particularly challenging to mount due to small, geographically-dispersed patient populations. In this article, we review two case studies involving the successful use of RWD or RWE in advancing the clinical development of treatments for rare diseases. Reference: [1] Hansen, et al.

Disease 52

Disease FDA FDA Approval Treatment 52

Conversations in Drug Development Trends

FEBRUARY 28, 2023

95% of rare diseases don’t have a treatment approved and won’t anytime soon. Uplifting Athletes As a 501(c)(3) nonprofit, UA harnesses the power of sport and partnerships with patient advocacy groups to fund the researchers developing datasets for rare diseases that have never been studied or understood before.

Clinical Trials 52

Clinical Trials Disease Trials Research 52

Perficient: Drug Development

MAY 28, 2024

This annual event aims to raise funds for the National Kidney Foundation, an organization that provides critical support to those affected by kidney disease. Action : The NKF ensures that 37 million Americans living with chronic kidney disease get diagnosed, treated and supported early.

Disease 98

Disease Research 98

Drug Target Review

AUGUST 6, 2024

A number of areas represent significant opportunities for Antibody Drug Conjugates (ADCs) beyond oncology, leveraging their ability to deliver therapeutic agents specifically to diseased cells or tissues while minimising off-target effects. Oncology also offers high returns and the opportunity to address severe, life-threatening conditions.

Therapies 117

Therapies Pharmaceutical Companies Disease Treatment 117

National Drug & Alcohol Research Centre Blog

FEBRUARY 12, 2024

Key findings: Alcohol is the seventh leading risk factor for mortality, disease, and disability. People with clinically significant diseases may be at increased risk of alcohol poisoning. “While we know that alcohol is a leading cause of mortality, we wanted to determine who is dying from acute alcohol poisoning.

Disease 110

Disease Treatment Drugs Research 110

keypoint

JULY 25, 2024

On September 10, 2024, Keystone Symposia will host a free ePanel event featuring the recipients of the Michelson Philanthropies & Science Prize for Immunology. The goal of the prize is to accelerate immunology advances with trans-disease applications towards vaccine and immunotherapy innovation.

Science 71

Science Vaccine International Research 71

Drugs.com

JANUARY 31, 2024

31, 2024 -- A disturbing number of people sick with an infectious disease conceal their illness to avoid missing work, travel or social events, new research reveals.About three in four people (75%) had either hidden an infectious. WEDNESDAY, Jan.

Disease 75

Disease Research 75

Broad Institute

DECEMBER 18, 2023

To achieve this, the authors called for more genetics and longitudinal data types from patients of diverse ancestries, more data- and tool-sharing across sectors, the development of quantitative biomarkers for measuring disease mechanisms, and more. But a new path for bringing treatments to patients is starting to emerge.

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Drug Development Clinical Trials Drugs Disease 130

The Premier Consulting Blog

JUNE 18, 2023

One exciting application of these technologies is the use of in silico trials in the development of novel therapies for rare diseases. However, with rare diseases there may be no available treatments that could serve as SoC or active control in a clinical trial and assigning patients to placebo may be unethical.

Drug Development 52

Drug Development Disease Clinical Trials Drugs 52

ASPET

JUNE 27, 2024

CB1 and CB2 agonists exhibit broad anti-inflammatory properties, suggesting their potential to treat inflammatory diseases. Secondary VAS and pharmacokinetic (PK) endpoints and adverse events were assessed. Background: Endocannabinoids, which are present throughout the central nervous system (CNS), can activate CB1 and CB2 receptors.

Pharmacokinetics 100

Pharmacokinetics FDA Approval FDA Disease 100

LifeSciVC

JANUARY 16, 2024

recent announcements from Merck and Sanofi for obesity and broader metabolic disease). Still may be some merit if they are clinical-stage and can achieve once-daily dosing without too steep a cut in efficacy or worsened adverse events vs. peptides, but be wary of the intensely competitive landscape. Join the club.

Small Molecule 137

Small Molecule Trials Therapies Disease 137

Conversations in Drug Development Trends

FEBRUARY 22, 2023

Rare Disease Day on February 28th is a chance for rare disease communities to come together as one and join in conversation with stakeholders searching for treatments, raising money to support research, and changing the way healthcare and governments interact with patients. In my case, my daughter Iris has GM1 gangliosidosis.

Disease 52

Disease Clinical Trials Trials Treatment 52

Drug Target Review

OCTOBER 9, 2023

Dr Laura Kerosuo explains that their discoveries cast fresh illumination on the sequence of events in early embryonic development. It can be applied to various inquiries, including the comparison of diseased and healthy tissue. The newfound insights hold the potential to enhance comprehension of a range of diseases.

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Therapies Doctors Disease Research 110