Chemical Biology and Drug Design

MAY 11, 2023

The figure depicts the neuroprotective role of crocin in Parkinson's disease. Abstract Parkinson's disease is among the most common forms of neurodegenerative illness, with present treatment being primarily symptomatic and frequently coming with substantial adverse effects.

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Broad Institute

SEPTEMBER 28, 2023

By Allessandra DiCorato September 28, 2023 Credit: Strittmatter Laboratory, Yale University Amyloid beta clusters (red) builds up among neurons (green) in a mouse model of Alzheimer’s disease. The scientists identified a suite of changes in cells unique to the early stages of Alzheimer’s, including some not seen before in animal studies.

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SCIENMAG: Medicine & Health

JANUARY 12, 2024

12, 2024) — The University of Kentucky will mark a decade of raising awareness and continuing its effort to warn women about the dangers of heart disease with the annual Healthy Hearts for Women Symposium. LEXINGTON, Ky. Credit: Peera_Sathawirawong, iStock/Getty Images Plus LEXINGTON, Ky.

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Disease 82

Drug Target Review

APRIL 11, 2024

Targeting pathways involved in SMC phenotypic modulation holds promise for developing novel therapeutic approaches for cardiovascular diseases. Can you explain the methodology used to investigate the genetic variants regulating extracellular matrix (ECM) secretion in SMCs, and predict proteins associated with vascular disease?

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Disease Engineering Regulations Clinical Research 59

Conversations in Drug Development Trends

AUGUST 29, 2024

By: Nathan Chadwick, Therapeutic Strategy Lead, Rare Disease Over the last few years in clinical trials, particularly within the rare disease community, a notable shift is underway, where patients and caregivers are taking the lead in reaching out to clinical trial sites rather than the other way around.

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Chemical Biology and Drug Design

FEBRUARY 13, 2024

Alzheimer's disease (AD) is a common age-related neurodegenerative brain disorder characterized by the impairment in memory and other cognitive functions. Abstract Alzheimer's disease (AD) is a common age-related neurodegenerative brain disorder characterized by the impairment in memory and other cognitive functions.

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Disease Treatment Therapies Research 100

SCIENMAG: Medicine & Health

AUGUST 28, 2023

military veterans with coronary artery disease, suboptimal lipid-lowering therapy was prevalent in the clinical setting. Optimization of statin therapy was projected to produce clinically relevant reductions in the risks of death and cardiovascular events. About The Study: In this study of 111,000 U.S.

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Therapies Disease 84

Broad Institute

FEBRUARY 7, 2024

However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. The team found that a key biological mechanism involved in a rare vascular disease may influence CAD risk.

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Drug Target Review

SEPTEMBER 9, 2024

functions to reset the immune system and potentially provide remission for allergic diseases? In allergic diseases, APCs identify and present unknown antigens to the immune system. This can lead to inadequate long-term effectiveness with low rates of disease remission. They also require frequent administration.

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Disease Immune Response Clinical Trials Treatment 64

BMG Labtech

OCTOBER 30, 2023

Cardiovascular disease, a group of disorders of the heart and blood vessels, is the number one cause of death across the world. One disorder in particular, atherosclerotic vascular disease, a chronic inflammatory disease associated with the formation of arterial plaques, is considered the major cause of cardiovascular diseases.

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Science Daily: Pharmacology News

JULY 5, 2023

Researchers have developed a soft, flexible, wireless device to monitor and treat heart disease and dysfunction in the days, weeks or months following traumatic heart-related events. And, after the device is no longer needed, it harmlessly dissolves inside the body, bypassing the need for extraction.

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Drug Target Review

JULY 7, 2023

Approximately three percent of the global population — 240 million people — experience autoantibody diseases, which occur when one’s own body attacks critical organs and tissues. This can create an abnormal immune response that attacks the cells of our bodies and contributes to the development of autoantibody diseases.

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Conversations in Drug Development Trends

APRIL 5, 2024

For others, this rare day is aptly the day we honor rare disease communities. Observed annually on the last day of February since 2008, Rare Disease Day has grown into a global movement for raising awareness, promoting research, and advocating for improved access to rare disease treatments and support services.

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Disease Clinical Trials Trials Treatment 52

Drug Channels

APRIL 4, 2022

Rare Disease Innovation & Partnering Summit. Hybrid Event May 17-19, 2022 | Boston, MA www.informaconnect.com/rare. Don’t miss the Rare Disease Innovation & Partnering Summit, coming up May 17-19, 2022 in Boston, MA. Visit www.informaconnect.com/rare for further details and to register. d/b/a Drug Channels Institute.

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Fierce BioTech

SEPTEMBER 20, 2023

In this podcast interview, Dan Fisher, managing director and practice lead for IPM.ai, explains the use of artificial intelligence for stitching together key medical events that may happen over a r | IPM.ai helps brands assess a unique patient population, accelerate clinical trial recruitment, and optimize commercial outcomes

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Clinical Trials Disease Trials 105

Broad Institute

JULY 6, 2023

The accuracy of these scores has improved for some diseases and groups of people, but they continue to fall short for those of non-European ancestry, mainly because the genetic datasets used to calculate these scores have largely come from people of European ancestry.

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Disease DNA Hospitals Medical Schools 97

Elrig

MAY 18, 2023

The most important drug discovery event of the year? 18-19 October 2023 The most important drug discovery event of the year? It’s with great excitement that we announce the return of ELRIG’s FREE TO ATTEND Drug Discovery 2023 (DD 2023); Europe’s leading event for the drug discovery community! Save the date! Save the date!

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Drugs Science Research Therapies 52

The Pharma Data

JANUARY 4, 2021

Investors can pre-register for the event here. Eduardo Schiffrin, Medical Director, will participate in a panel discussion at the LifeSci Partners 10 th Annual Healthcare Corporate Access Event on Friday, January 8 from 11am Eastern Standard Time. Investors can pre-register for the event here. LAUSANNE, Switzerland, Jan.

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KIF1A

APRIL 13, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. In cases of hypoxic-ischemic encephalopathy (HIE), the developing child’s brain is damaged by an event of restricted bloodflow and loss of oxygen.

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Disease Research Science 111

Conversations in Drug Development Trends

FEBRUARY 28, 2023

95% of rare diseases don’t have a treatment approved and won’t anytime soon. Uplifting Athletes As a 501(c)(3) nonprofit, UA harnesses the power of sport and partnerships with patient advocacy groups to fund the researchers developing datasets for rare diseases that have never been studied or understood before.

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Clinical Trials Disease Trials Research 52

Olympian Clinical Research

SEPTEMBER 16, 2022

million Americans were living with Alzheimer’s disease in 2021, according to the Centers for Disease Control and Prevention (CDC). Alzheimer’s disease is the seventh leading cause of death in the United States and is a devastating disease that can rob people of their memories and lives. Eating a Healthy Diet.

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Plenge Gen

MARCH 26, 2019

While most of the study focuses on Mendelian randomization to establish a relation among ACLY genetic variation, LDL cholesterol levels, and cardiovascular events, in this blog I focus on a topic highlighted in the companion NEJM editorial: human genetics to predict on-target adverse drug events (see NEJM editorial here ).

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Drugs Disease 52

The Premier Consulting Blog

OCTOBER 11, 2022

Clinical trials for ultra-rare diseases can be particularly challenging to mount due to small, geographically-dispersed patient populations. In this article, we review two case studies involving the successful use of RWD or RWE in advancing the clinical development of treatments for rare diseases. Reference: [1] Hansen, et al.

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The Pharma Data

JANUARY 25, 2021

Fried Food Intake May Increase Cardiovascular Disease Risk. 25, 2021 — Fried food consumption is associated with an increased risk for cardiovascular disease, according to a meta-analysis published online Jan. to 1.43) for major cardiovascular events, 1.22 (95 percent confidence interval, 1.07 Professional. MONDAY, Jan.

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Disease Science Research 52

The Premier Consulting Blog

JUNE 18, 2023

One exciting application of these technologies is the use of in silico trials in the development of novel therapies for rare diseases. However, with rare diseases there may be no available treatments that could serve as SoC or active control in a clinical trial and assigning patients to placebo may be unethical.

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Drug Channels

OCTOBER 4, 2021

Informa Connect’s Rare Disease Innovation & Partnering Summit. Hybrid Event. After over a year apart, Informa Connect is pleased to announce that Rare Disease Innovation & Partnering Summit will return this Winter as a hybrid event, in-person December 6-7 in Boston, MA and virtually December 9-10.

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Disease Drug Development Engineering FDA 40

Drugs.com

JUNE 13, 2024

THURSDAY, June 13, 2024 -- Climate change is harming the heart health of people around the world, a new review warns.Extreme temperatures, hurricanes and other dangerous weather events all contribute to an increased risk of heart disease and.

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Disease 98

Drug Discovery Today

JULY 29, 2022

Geneva-based event pledges five Swiss francs per visitor to support new drug development project

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The Pharma Data

NOVEMBER 18, 2020

Genetics Tied to Thromboembolism Risk With Inflammatory Bowel Disease. 18, 2020 — Genetic variants in some patients with inflammatory bowel disease (IBD) are associated with a significantly increased risk for developing thromboembolic disease (TED), according to a study published online Oct. percent had TED events.

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The Pharma Data

DECEMBER 10, 2020

After an extensive study of the viral genetic signature associated with that conference, a new study published in the journal Science suggests the Biogen conference was a super-spreader event of unknown proportions. The number of infections associated with the conference started small.

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The Pharma Data

JANUARY 19, 2021

19, 2021 — Delicious but deadly: Eating fried food is tied to an increased risk of heart disease and stroke , a new study suggests. They combined data from 17 studies, involving more than 560,000 people with nearly 37,000 major cardiovascular events, such as heart attack or stroke. TUESDAY, Jan. 19 in the journal Heart.

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Disease Science Research Production 52

keypoint

JULY 25, 2024

On September 10, 2024, Keystone Symposia will host a free ePanel event featuring the recipients of the Michelson Philanthropies & Science Prize for Immunology. The goal of the prize is to accelerate immunology advances with trans-disease applications towards vaccine and immunotherapy innovation.

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The Pharma Data

AUGUST 30, 2021

Positive high-level results from the FoCus Phase III trial in Wilson disease showed ALXN1840 met the primary endpoint with a statistically significant improvement in daily mean copper mobilisation from tissues, demonstrating superiority compared with standard-of-care (SoC) treatments. Wilson disease. 1, 2, 3.

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Conversations in Drug Development Trends

FEBRUARY 22, 2023

Rare Disease Day on February 28th is a chance for rare disease communities to come together as one and join in conversation with stakeholders searching for treatments, raising money to support research, and changing the way healthcare and governments interact with patients. In my case, my daughter Iris has GM1 gangliosidosis.

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Disease Clinical Trials Trials Treatment 52

SCIENMAG: Medicine & Health

FEBRUARY 21, 2024

Using intravascular imaging to guide stent implantation during percutaneous coronary intervention (PCI) in heart disease patients significantly improves survival and reduces adverse cardiovascular events compared to angiography-guided PCI alone, the most commonly used method.

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Disease 83

ASPET

NOVEMBER 30, 2023

In this study, we evaluated the long-term efficacy of novel synthetic neurosteroids in preventing the development of chronic epilepsy and hyperexcitable ictal events in a rat OP model of SE. It significantly reduced the occurrence of epileptic biomarkers of HFOs and interictal spikes, indicating potential disease-modifying activity.

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The Pharma Data

APRIL 7, 2021

Sutimlimab, a first-in-class investigational C1s inhibitor, has the potential to be the first approved treatment for hemolysis in adults with cold agglutinin disease, a serious and chronic autoimmune hemolytic anemia. Sutimlimab has the potential to address a major unmet medical need for people with cold agglutinin disease.”.

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