Drug Discovery World

AUGUST 23, 2023

The US Food and Drug Administration (FDA) has approved the first vaccine for pregnant individuals to prevent respiratory syncytial virus (RSV) in infants. This approval provides an option for healthcare providers and pregnant individuals to protect infants from this potentially life-threatening disease.”

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Drug Discovery World

AUGUST 24, 2022

It will also assess the time taken until throat and lesion swabs test negative for monkeypox virus and the proportion of patients who require hospitalisation due to complications from the disease. . Tecovirimat prevents the Monkeypox virus from leaving infected cells, helping stop its spread within the body.

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The Pharma Data

APRIL 27, 2023

RSV causes over 270,000 hospitalisations and approximately 20,000 in-hospital deaths in adults aged 60 years and older each year in Europe. 1 If approved, GSK’s candidate has the potential to be the first vaccine available to help protect older adults from RSV disease.

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Drug Discovery World

OCTOBER 17, 2023

CARsgen has published evidence of over seven years of disease-free survival in advanced hepatocellular carcinoma (HCC) following treatment with its CAR-GPC3 T cell therapy. Throughout the follow-up period, both patients only received oral anti-hepatitis B virus medication, with no other cancer treatments administered.

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Broad Institute

JUNE 18, 2024

Simple test for flu could improve diagnosis and surveillance By Allessandra DiCorato June 18, 2024 Breadcrumb Home Simple test for flu could improve diagnosis and surveillance A low-cost CRISPR-based paper strip test distinguishes between influenza types and can be reprogrammed to recognize different viruses including the H5N1 bird flu virus.

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The Pharma Data

APRIL 8, 2022

Using a Human Lung Chip that replicates the structures and functions of the lung air sac, or “alveolus,” the research team discovered that applying mechanical forces that mimic breathing motions suppresses influenza virus replication by activating protective innate immune responses. During his Ph.D.

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Drug Discovery World

JUNE 23, 2023

The Food and Drug Administration (FDA) has granted accelerated approval to Elevidys (delandistrogene moxeparvovec-rokl), an adeno-associated virus (AAV) based gene therapy for the treatment of DMD. Sarepta Therapeutics’ Elevidys has become the first gene therapy for Duchenne muscular dystrophy (DMD) to gain marketing authorisation in the US.

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Broad Institute

FEBRUARY 8, 2024

Researchers uncover genetic factors for severe Lassa fever By Allessandra DiCorato February 8, 2024 Breadcrumb Home Researchers uncover genetic factors for severe Lassa fever New findings from an international collaboration pave the way for studies of highly infectious diseases in Africa such as Ebola. Chan School of Public Health.

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Drug Discovery World

JUNE 6, 2024

Professor Charles Swanton, Cancer Research UK’s chief clinician, said the melanoma trial results were “extremely impressive”, adding: “The new vaccine approach is another piece of the puzzle that will allow more patients to be cured, hopefully, or fewer patients to suffer disease relapse. The follow-up of the Phase IIb study took place 34.9

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The Pharma Data

JUNE 7, 2023

This authorisation for Arexvy means eligible adults can be vaccinated against RSV disease for the first time, reinforcing GSK’s long history of vaccine innovation. 1 Those with underlying medical conditions, such as diabetes and chronic heart and lung disease, drive the majority of RSV hospitalisations.

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The Pharma Data

AUGUST 24, 2020

They say genome sequencing shows the two strains of the virus are “clearly different”, making it the world’s first proven case of reinfection. Those infected develop an immune response as their bodies fight off the virus which helps to protect them against it returning.

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Codon

AUGUST 26, 2024

When COVID-19 emerged in 2019, by contrast, mRNA vaccines developed by Pfizer and Moderna took just 326 days from the initial sequencing of the virus to gaining approval for emergency use. These drugs would be ideal tools to bridge the wait for a vaccine against a quickly-spreading virus. Unsubscribe any time.

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Drug Discovery World

AUGUST 31, 2022

A new study, published in the Annals of Internal Medicine , shows that higher levels of viral antigen in the blood, which could indicate ongoing SARS-CoV-2 replication, correlated with more severe disease. . Analysis of Covid patient blood samples.

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PLOS: DNA Science

JULY 27, 2023

That information led, thanks to vaccine shelved from the first SARS circa 2003, to the rapid development and deployment of mRNA vaccines against the new infectious disease. The owners of the felines all reported feeding their pets raw meat, and samples of the meat revealed not only flu virus genetic material, but also infectious virus.

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The Pharma Data

DECEMBER 9, 2020

9, 2020 — In a sign that the COVID-19 pandemic is entering its most dire stage yet, new federal data show that more than a third of Americans now live in areas where hospitals are critically short of intensive care beds. “This disease progresses very quickly and can get very ugly very fast. WEDNESDAY, Dec. © 2020 HealthDay.

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The Pharma Data

SEPTEMBER 4, 2020

The main test used to diagnose coronavirus is so sensitive it could be picking up fragments of dead virus from old infections, scientists say. He believes the detection of traces of old virus could partly explain why the number of cases is rising while hospital admissions remain stable. Image copyright. Getty Images.

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Drug Discovery World

MAY 25, 2023

Addressing diseases of unmet need through high content phenotypic screening The second presentation was given by Neil Carragher, Professor of Drug Discovery and Director of Translation at the University of Edinburgh, who discussed the benefits of high content phenotypic screening.

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The Pharma Data

DECEMBER 1, 2020

1, 2020 — Yet another grim record for COVID-19 hospitalizations was set on Monday, as more than 96,000 patients battled severe cases of the virus in hospital wards across America. But the number of hospitalizations have risen by more than 12 percent over the past week, the newspaper noted. TUESDAY, Dec.

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Drug Discovery World

SEPTEMBER 13, 2023

These results are compared to those of a recent study, which has shown showing that the SARS-CoV-2 virus causing Covid-19 can trigger the activation of the HERV-W retrovirus, which may result in post-infectious syndromes or diseases associated with persistent HERV-W ENV expression in genetically predisposed individuals.

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The Pharma Data

MAY 16, 2022

million symptomatic cases of the virus, as well as 690,000 hospitalizations and more than 110,000 deaths. She adds that the results, “highlight the opportunity to continue widespread vaccination uptake to prevent COVID-19 related disease and generate societal benefits.”

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The Pharma Data

DECEMBER 3, 2020

New Tau Protein is Abnormal in Very Early Alzheimer’s Disease. Investigators with the University of Gothenburg identified new forms of tau protein that become abnormal in the very early stages of Alzheimer’s disease, even before the development of cognitive problems. Kidney Disease Leading Risk Factor for COVID-related Hospitalization.

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The Pharma Data

DECEMBER 29, 2020

29, 2020 /PRNewswire/ — Phase 3 program in hospitalized patients to continue based on passing futility analysis on ability to reduce incidence of death or mechanical ventilation. First antibody therapy to demonstrate anti-viral effect in patients hospitalized with COVID-19. TARRYTOWN, N.Y. , Regeneron Pharmaceuticals, Inc.

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Drug Discovery World

FEBRUARY 27, 2023

However, the researchers urge caution as the majority of patients have not reached the age of four to five years where the most severe stages of disease progression typically present. Patients with MPS-IIIA have a mutation in the SGSH gene, causing them to lack an enzyme which normally breaks down large sugar molecules.

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Drug Discovery World

JULY 12, 2022

It outlines that whilst there are 61 vaccine candidates in clinical development targeting diseases listed on WHO’s bacterial priority pathogen list 2 , most of these will not be available anytime soon. . Haemophilus influenzae ?type type b) Tuberculosis? mycobacterium tuberculosis) ?and and Typhoid fever ( Salmonella? Typhi). .

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The Pharma Data

DECEMBER 17, 2020

(NASDAQ: REGN ) today announced that the New England Journal of Medicine (NEJM) has published initial clinical data from an ongoing seamless Phase 1/2/3 trial of the antibody cocktail casirivimab and imdevimab in non-hospitalized patients with COVID-19. “The investigational cocktail is now available to indicated high-risk U.S.

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Drug Discovery World

FEBRUARY 5, 2024

Williams discussed the advantages of the company’s ‘disease agnostic’ small molecule degraders, and its success so far in translating results from preclinical to clinical tests in dermatology, inflammation and oncology indications. Product launches More than 400 exhibitors are at the event this year, many of whom are launching new products.

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Drug Discovery World

OCTOBER 31, 2022

The research from the Centers for Disease Control and Prevention’s VISION Network analysed real-world data on mRNA vaccine effectiveness during Omicron BA.4 A new study in the US has revealed that the Covid-19 vaccine is less effective in people with weakened immune systems. . 5 predominance for immunocompromised adults. .

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The Pharma Data

DECEMBER 3, 2020

Centers for Disease Control and Prevention warned Wednesday that the coming winter months might be the darkest period yet in the coronavirus pandemic. Another record-breaking day of COVID-19 hospitalizations and deaths underscored Redfield’s grim warning. THURSDAY, Dec. 3, 2020 – The head of the U.S. Things are not shut down.”

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The Pharma Data

OCTOBER 30, 2020

(NASDAQ: REGN) received today a recommendation from the independent data monitoring committee (IDMC) for the REGN-COV2 antibody cocktail treatment trials for COVID-19 that the current hospitalized patient trial be modified. About the REGN-COV2 Trial in Hospitalized Patients. Cohort 1A: patients not requiring oxygen.

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Broad Institute

SEPTEMBER 30, 2024

Today, about a third of Broad’s Terra users are from the public health workforce; in the US, 76 state and local public health labs use the platform for preventing and monitoring infectious disease spread in their communities. This was true in the US and all the more in the Global South, where the burden of infectious disease is the highest.

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The Pharma Data

JANUARY 20, 2021

Trial designed to investigate the cardioprotective properties of CardiolRx(TM) in patients hospitalized with COVID-19 who have a prior history of, or risk factors for, cardiovascular disease. Oakville, Ontario–(Newsfile Corp. Dr. . Cardiol Therapeutics Inc. (

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Drug Discovery World

APRIL 20, 2023

To date, it seems that the likely mechanism of post- Covid-19 cognitive impairment is neuroinflammation triggered by the peripheral / systemic inflammation caused by the virus. Alzheimer’s disease), or by initiating a new one. There is strong evidence for widespread brain changes following Covid-19. depression).

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The Pharma Data

OCTOBER 28, 2020

REGN-COV2 significantly reduced viral load and patient medical visits (hospitalizations, emergency room, urgent care visits and/or physician office/telemedicine visits). In the overall patient group with detectable virus at baseline, the average daily reduction in viral load through day 7 was a 0.36 There was a 1.08

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The Pharma Data

APRIL 22, 2023

(Nasdaq: GILD) today announced positive results from several COVID-19 clinical and real-world evidence studies being presented at the 33rd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID). Patients were randomized 2:1 to receive Veklury (n=163) or placebo (n=80), in addition to standard of care.

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The Pharma Data

FEBRUARY 1, 2021

HOUSTON, TX, February 01, 2021 /24-7PressRelease/ — It has been just over a year since the COVID-19 virus arrived in the United States, already claiming the lives of over 400,000 Americans. Medical professionals are desperately seeking effective treatments as hospitals are continuously overwhelmed with COVID-19 patients.

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The Pharma Data

SEPTEMBER 2, 2020

Deaths of people in their own homes were far above normal levels in July in contrast to below-average levels of non-Covid-19 deaths in hospitals and care homes, figures show. The Office for National Statistics says patients in England and Wales may not be being admitted to hospital or they are discharged earlier than usual.

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The Pharma Data

DECEMBER 22, 2020

This study was conducted between April and June 2020 among women who came to one of three Boston area hospitals either for treatment of COVID-19 or for delivery. None of the newborns of the 127 pregnant women, including 64 who had varying levels of illness from the virus, tested positive for the coronavirus.

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