Disease, Immune Response and Medical Schools

AI tool predicts new viral variants and could improve vaccines

Drug Discovery World

OCTOBER 13, 2023

The UK’s University of Oxford is taking the lead on two collaborative international projects to improve the response to new Covid-19 variants and contribute to future pandemic preparedness. According to the European Centre for Prevention and Disease Control, the current variants of interest are Omicron variants BA.2.75,

Vaccine

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Routine vaccines as effective as antibodies against Alzheimer’s

Drug Discovery World

AUGUST 25, 2023

A new study at UTHealth Houston in the US has found that several routine vaccinations are linked to a significant reduced risk of Alzheimer’s disease (AD). Paul Schulz, the Rick McCord Professor in Neurology with McGovern Medical School at UTHealth Houston, was senior author of the study.

Vaccine

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Personalised mRNA cancer vaccine prolongs survival in melanoma

Drug Discovery World

APRIL 16, 2023

Vaccine strategies over the last 25 years attempted to induce immune responses against tumour-associated antigens that are not absolutely specific to the tumour,” said presenting author Jeffrey Weber, Deputy Director of the NYU Langone Perlmutter Cancer Center and Laura and Isaac Perlmutter Professor of Oncology at NYU Grossman School of Medicine.

Vaccine

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US researchers decipher how one gut bacterium influences immunity

Drug Discovery World

JULY 29, 2022

From immunity to metabolism to mental health, it seems like the gut microbiome has been linked to every aspect of human health and disease. The usual suspects for triggering an immune response would be a protein or a sugar,” said Clardy. muciniphila’s ability to manipulate the immune system and fight disease.

Research

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Revolutionary nanoparticles enable gene-editing in lungs

Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs.

RNA

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Not all neoantigens are created equal

Drug Target Review

DECEMBER 28, 2023

These neoantigens are identified by T cells of the immune system as foreign proteins and thus trigger an immune response. Neoantigens are recognised as non-self and trigger an immune response. Patients with high numbers of clonal neoantigens show improved disease-free survival.

Bioinformatics

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Researchers decipher how a gut bacterium influences immunity

Broad Institute

JULY 26, 2022

Researchers decipher how a gut bacterium influences immunity By Corie Lok July 26, 2022 Breadcrumb Home News Researchers decipher how a gut bacterium influences immunity Study finds a molecule made by the bacterium that helps moderate immune responses. It gets its name from the intestinal mucus it breaks down.

Research

Research Immune Response Medical Schools Disease

Laurie Glimcher

Broad Institute

JUNE 14, 2023

She is also director of the Dana-Farber/Harvard Cancer Center and the Richard and Susan Smith Professor of Medicine at Harvard Medical School. Previously, she was the Stephen and Suzanne Weiss Dean and Professor of Medicine of Weill Cornell Medicine and provost for medical affairs of Cornell University. Glimcher, M.D.,

Medical Schools

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A backpack full of multiple sclerosis therapy

The Pharma Data

APRIL 22, 2023

Multiple sclerosis (MS) is a devastating autoimmune disease that destroys the protective myelin covering around nerves, disrupting communication between the brain and body, and causing patients’ ability to move and function to progressively decline. million individuals that currently have to live with the disease.

Therapies

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A surprising new role for a major immune regulator

Broad Institute

AUGUST 7, 2023

Now, a team of MIT, Massachusetts General Hospital (MGH), Broad Institute of MIT and Harvard, and Harvard Medical School (HMS) researchers has discovered how STING activates those two pathways. Food and Drug Administration has not approved any STING agonist thus far, although multiple clinical trials are currently underway.

Regulations

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New “dictionary” of immune responses reveals far more complexity in the immune system than previously thought

Broad Institute

DECEMBER 6, 2023

The immune system can carry out many biological processes, from killing viruses to fighting cancer, thanks in large part to approximately 100 key cell-signaling proteins called cytokines, which instruct immune cells what to do. The reference, called the Immune Dictionary , appears today in Nature.

Immune Response

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Therapeutic Vaccine Is Keeping Melanoma in Remission 4 Years On

The Pharma Data

JANUARY 25, 2021

25, 2021 — Giving melanoma patients a “personalized” vaccine can prompt an anti-tumor immune response that lasts for years, an early study finds. But it builds on earlier work showing it is possible to spur the immune system to respond to an individual’s unique tumor. MONDAY, Jan. SOURCES: Patrick A.

Vaccine

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Tiziana Life Sciences plc announces completion of the clinical trial with nasally administered Foralumab, its proprietary fully human anti-CD3 monoclonal antibody, for the treatment of COVID-19 patients in Brazil

The Pharma Data

JANUARY 3, 2021

The clinical study was completed in collaboration with scientific teams at the Harvard Medical School (Boston, USA), Santa Casa de Misericórdia de Santos Hospital (Santos, Brazil) and INTRIALS, a world-class, full-service Latin American CRO based in São Paulo, Brazil. . NEW YORK and LONDON, Jan. NEW YORK and LONDON, Jan.

Clinical Trials

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Tiziana Announces Initiation of Clinical Trial with Covid-19 Patients in Brazil with Nasally Administered Foralumab, a Fully Human Anti-CD3 Monoclonal Antibody

The Pharma Data

NOVEMBER 1, 2020

Highly innovative first-in-class study for treating COVID-19 disease with nasally administered drug. Trial facilitated with coll a boration of Harvard Medical School and one of the world’s top Neurologist, Dr. Howard Weiner. Clinical Data Expected by End of Year. NEW YORK and LONDON, Nov.

Clinical Trials

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T-cell receptors offer window to the cell for a new class of cancer therapeutics

Drug Target Review

JANUARY 15, 2024

This produces a great advantage in infectious disease, as it becomes difficult for a virus to adapt and spread from person to person, because each person’s HLA array is genetically distinct. Therefore, therapeutically useful tumour antigens represent a tiny fraction of the genes expressed by a tumour cell.

Engineering

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Advances in the Battle Against Autoimmune Disease

The Pharma Data

DECEMBER 15, 2020

A healthy immune system defends the body against disease and other conditions. However, if the immune system malfunctions, it can attack healthy cells, tissues and organs. Autoimmune disease impacts different parts of the body, weakening functionality. Autoimmune diseases affect more than 24 million people in the U.S.

Disease

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Another COVID-19 Vaccine Candidate Begins Final Clinical Trials

The Pharma Data

DECEMBER 29, 2020

The vaccine — which right now is known as NVX-CoV2373 — comes in two doses and is designed to enhance the body’s immune response to the coronavirus’ distinctive spike protein. National Institute of Allergy and Infectious Diseases, said last week. “They know someone who had a severe case or died. .

Clinical Trials

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Drug Discovery Digest

AI tool predicts new viral variants and could improve vaccines

Routine vaccines as effective as antibodies against Alzheimer’s

Trending Sources

Personalised mRNA cancer vaccine prolongs survival in melanoma

US researchers decipher how one gut bacterium influences immunity

Revolutionary nanoparticles enable gene-editing in lungs

Not all neoantigens are created equal

Researchers decipher how a gut bacterium influences immunity

Laurie Glimcher

A backpack full of multiple sclerosis therapy

A surprising new role for a major immune regulator

New “dictionary” of immune responses reveals far more complexity in the immune system than previously thought

Therapeutic Vaccine Is Keeping Melanoma in Remission 4 Years On

Tiziana Life Sciences plc announces completion of the clinical trial with nasally administered Foralumab, its proprietary fully human anti-CD3 monoclonal antibody, for the treatment of COVID-19 patients in Brazil

Tiziana Announces Initiation of Clinical Trial with Covid-19 Patients in Brazil with Nasally Administered Foralumab, a Fully Human Anti-CD3 Monoclonal Antibody

T-cell receptors offer window to the cell for a new class of cancer therapeutics

Advances in the Battle Against Autoimmune Disease

Another COVID-19 Vaccine Candidate Begins Final Clinical Trials

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