Ebola virus disease – Guinea
The Pharma Data
JUNE 18, 2021
On 14 February 2021, the Ministry of Health (MoH) of Guinea informed WHO of a cluster of Ebola Virus. Source link.
Disease Information Virus 
Eclectic Genomics: Cat Flu, Dolphin Adaptation to Climate Change, Predicting Cancer, and Diagnosing Rare Disease
PLOS: DNA Science
JULY 27, 2023
That information led, thanks to vaccine shelved from the first SARS circa 2003, to the rapid development and deployment of mRNA vaccines against the new infectious disease. The owners of the felines all reported feeding their pets raw meat, and samples of the meat revealed not only flu virus genetic material, but also infectious virus.
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Targeting a human protein may stop Ebola virus in its tracks
The Pharma Data
MARCH 23, 2022
To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase. Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Drugs that target polymerase could potentially treat Ebola virus infections and save lives.
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Coronavirus: Asymptomatic cases 'carry same amount of virus'
The Pharma Data
AUGUST 6, 2020
People with symptomless Covid-19 can carry as much of the virus as those with symptoms, a South Korean study has suggested. But the researchers weren’t able to say how much these people actually passed the virus on. This study gives us some more information about what they look like in the body. Image copyright.
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WHO launches global network to detect and prevent infectious disease threats
The Pharma Data
MAY 22, 2023
WHO launches global network to detect and prevent infectious disease threats WHO and partners are launching a global network to help protect people from infectious disease threats through the power of pathogen genomics. New, more transmissible variants of the virus would not have been as quickly identified.
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Hong Kong reports 'first case' of virus reinfection
The Pharma Data
AUGUST 24, 2020
They say genome sequencing shows the two strains of the virus are “clearly different”, making it the world’s first proven case of reinfection. Those infected develop an immune response as their bodies fight off the virus which helps to protect them against it returning.
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A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic
Broad Institute
APRIL 25, 2024
He started to imagine how the deadly and contagious disease, if confirmed, might spread to half the city’s population. Eight of the 20 patients died, but the spread of the disease in Nigeria stopped there. Blood and urine samples from the man were waiting for Happi in his lab. Happi felt chilled. They called the idea Sentinel.
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PREVEXXION® RN: the next generation of Marek’s disease vaccines now available in the EU and the UK
The Pharma Data
APRIL 14, 2021
The product’s early Marek’s disease onset of immunity from five days of age provides full protection of broilers, layers and breeders against the most virulent Marek’s disease virus strains. Its purpose is to provide poultry producers with cutting-edge technology in terms of Marek’s disease protection.
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Oyagen, Inc. Publishes Study On Its OYA1 As A “Highly Effective” Experimental Drug Candidate For Treating Infections By The Ebola Virus
The Pharma Data
JANUARY 6, 2021
A Novel Ebola Virus VP40 Matrix Protein-Based Screening for Identification of Novel Candidate Medical Countermeasures.’ The published study results showed that OYA1 was “highly effective” in reducing the spread of Ebola Virus infection in laboratory tests with the live Ebola virus carried out by NIAID.
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The Importance of Hazard Communications in Clinical Trials Involving Genetic Engineering
Advarra
JUNE 13, 2024
The following information includes common elements to consider in site hazard communications and use of this “bundling” approach to simplify things for stakeholders (this is the approach Advarra’s IBC has taken). However, some degree of virulence and risk is acceptable, depending on the disease and subject population being treated.
Could Gene Therapy Cure Sickle Cell Disease? Two New Studies Raise Hopes
The Pharma Data
DECEMBER 5, 2020
5, 2020 — A pair of new gene therapies promise a potentially lasting cure for sickle cell disease by subtly altering the genetic information in patients’ bone marrow cells, researchers report. Bluebird’s method “uses a virus to drop an entire gene encoding a new hemoglobin. SATURDAY, Dec.
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Biden COVID Advisor Says Poor Preparation, Changing Virus Could Slow Vaccine Effort
The Pharma Data
JANUARY 21, 2021
President Joe Biden has promised to re-energize the nation’s response to COVID-19, but one of his top pandemic advisors says that effort could be hamstrung by both the virus and the failings of the previous administration. Further Support and Information on COVID-19. © 2021 HealthDay. All rights reserved. Posted: January 2021.
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The Vaccine Development Landscape and Its Associated Challenges
DrugBank
JULY 18, 2024
Vaccines have consistently demonstrated their efficacy in protecting people from infectious diseases. This led to the eradication of smallpox and polio – two debilitating diseases that historically caused global epidemics. Let’s take a deeper dive into these challenges.
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U.S. Sets Another Daily Record for COVID Cases as Virus Spreads on College Campuses
The Pharma Data
NOVEMBER 6, 2020
universities reopened their campuses to students in some capacity this fall, the newspaper said, and some schools have appeared to keep the virus in check, primarily through extensive testing programs. Further Support and Information on COVID-19. More than a third of U.S. Even so, the U.S. Another $1.2 By Friday, the U.S.
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VALNEVA AND PFIZER COMPLETE RECRUITMENT FOR PHASE 2 TRIAL OF LYME DISEASE VACCINE CANDIDATE
The Pharma Data
JULY 21, 2021
Valneva SE (Nasdaq: VALN; Euronext Paris: VLA), a specialty vaccine company focused on the development and commercialization of prophylactic vaccines for infectious diseases with significant unmet medical need, and Pfizer Inc. About Lyme Disease. Juan Carlos Jaramillo M.D., About VLA15.
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Regeneron’s COVID-19 Outpatient Trial Prospectively Demonstrates that REGN-COV2 Antibody Cocktail Significantly Reduced Virus Levels and Need for Further Medical Attention
The Pharma Data
OCTOBER 28, 2020
In the overall patient group with detectable virus at baseline, the average daily reduction in viral load through day 7 was a 0.36 About REGN-COV2 REGN-COV2 is a combination of two monoclonal antibodies (REGN10933 and REGN10987) and was designed specifically to block infectivity of SARS-CoV-2, the virus that causes COVID-19.
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Analytical Testing Considerations for Gene Therapy Products
The Premier Consulting Blog
MARCH 7, 2024
The FDA’s January 2020 guidance, Chemistry, Manufacturing and Control (CMC) [1] Information for Human Gene Therapy Investigational New Drug Applications (INDs), outlines the analytical methods that define the quality, safety and efficacy of gene therapy therapeutics.
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WHO update on Omicron
The Pharma Data
NOVEMBER 29, 2021
1.1.529 a variant of concern, named Omicron, on the advice of WHO’s Technical Advisory Group on Virus Evolution (TAG-VE). Severity of disease : It is not yet clear whether infection with Omicron causes more severe disease compared to infections with other variants, including Delta.
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Q&A: How Terra became a backbone of public health pathogen surveillance
Broad Institute
SEPTEMBER 30, 2024
Today, about a third of Broad’s Terra users are from the public health workforce; in the US, 76 state and local public health labs use the platform for preventing and monitoring infectious disease spread in their communities. This was true in the US and all the more in the Global South, where the burden of infectious disease is the highest.
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SARS-CoV-2: advancing the production of the ACE2 protein
Drug Target Review
JANUARY 26, 2024
These ACE2-coated particles could be tested as an anti-viral therapeutic, and as sensors for detecting virus particles. To find a DNA fragment that contained the intact ACE2 gene, complete with its embedded regulatory information, they searched libraries of cloned DNA fragments generated as part of the Human Genome Project.
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FDA to Hold Advisory Committee Meeting on COVID-19 Vaccines to Discuss Future Boosters
The Pharma Data
MARCH 21, 2022
April 6, to discuss considerations for future COVID-19 vaccine booster doses and the process for selecting specific strains of the SARS-CoV-2 virus for COVID-19 vaccines to address current and emerging variants. Centers for Disease Control and Prevention and the National Institutes of Health will participate in the meeting. “As
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2021 Young Scientist Award winners announced
The Pharma Data
JUNE 30, 2021
For their remarkable scientific contributions, doctoral student Julia Klaus, Zurich University VetSuisse Faculty, and Dr Yasmin Parr from the MRC-University of Glasgow, Centre for Virus Research, have received the 2021 ABCD Young Scientist Award. To foster young talent development in the feline health research community.
Farma: Speculative Gastronomy
Codon
OCTOBER 13, 2024
Through genetic engineering, researchers have developed Golden Rice which can help address the problem of vitamin A deficiency , cotton that produces its own insecticide , virus-resistant papayas , and more. One of these is “citrus canker,” a bacterial disease that causes the fruits to develop necrotic lesions.
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Addressing increasingly resistant drugs by infectious agents
Drug Target Review
SEPTEMBER 4, 2023
There have been several studies that have reported the ability of infectious disease agents to be drug resistant. Infectious agent includes bacteria, virus, fungi, and parasites, and they are capable of causing disease in a living organism. 7,13 The use of Plants extract is important in drug discovery.
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COVID Doesn’t Pass From Mom to Fetus During Pregnancy: Study
The Pharma Data
DECEMBER 22, 2020
None of the newborns of the 127 pregnant women, including 64 who had varying levels of illness from the virus, tested positive for the coronavirus. The study also included 63 pregnant women who tested negative for the virus and 11 reproductive-age women who were not pregnant, to provide comparison. ” © 2020 HealthDay.
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U.S. FDA APPROVES TICOVAC™, PFIZER’S TICK-BORNE ENCEPHALITIS (TBE) VACCINE
The Pharma Data
AUGUST 15, 2021
adults and children against the TBE virus when visiting or living in TBE endemic areas. Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices (ACIP) is expected to discuss recommendations on the safe and appropriate use of TICOVAC. Important Safety Information for TICOVAC.
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Brazilian Coronavirus Variant Found in Minnesota
The Pharma Data
JANUARY 26, 2021
The person is being interviewed for more information about their illness, travel, and contacts, the Associated Press reported. “We know that even as we work hard to defeat COVID-19, the virus continues to evolve as all viruses do,” Minnesota Health Commissioner Jan Malcolm said in a statement. Associated Press Article.
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Coronavirus: Children's role in spread puzzles scientists
The Pharma Data
AUGUST 28, 2020
Earlier studies have found the vast majority of children with the virus have mild or no symptoms. But these findings shed light on the unresolved question of how likely children are to spread the virus to others. How severely do they get the virus? Do they pass it on to others? What does the South Korean study say?
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Medicago and GSK announce the approval by Health Canada of COVIFENZ®, an adjuvanted plant-based COVID-19 vaccine
The Pharma Data
FEBRUARY 24, 2022
Medicago, a biopharmaceutical company headquartered in Quebec City, and GlaxoSmithKline (GSK) today announced that Health Canada has granted approval for COVIFENZ®, COVID-19 vaccine, (plant-based virus-like particles [VLP], recombinant, adjuvanted). This vaccine is indicated for active immunization to prevent coronavirus disease 2019 (COVID?19)
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Clover Biopharmaceuticals Announces Publication of Phase 1 Clinical Trial Data for its Adjuvanted COVID-19 Vaccine Candidates in The Lancet
The Pharma Data
JANUARY 31, 2021
Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. For more information, please visit our website: www.cloverbiopharma.com. For more information, visit www.dynavax.com. . CHENGDU, China , Feb. About Dynavax.
Answering Your Qs on the New COVID Vaccines
The Pharma Data
JANUARY 11, 2021
The COVID-19 vaccines work by teaching the immune system to protect against the virus, experts said. Neither of the two vaccines approved in the United States — made by Pfizer-BioNTech and Moderna — contains the live virus. Centers for Disease Control and Prevention. Further Support and Information on COVID-19.
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Preliminary Findings from a Phase 2a Trial of Investigational COVID-19 Therapeutic Molnupiravir
The Pharma Data
MARCH 8, 2021
The companies today reported findings on one secondary objective from the Phase 2a study, showing a reduction in time (days) to negativity of infectious virus isolation in nasopharyngeal swabs from participants with symptomatic SARS-CoV-2 infection, as determined by isolation in Vero cell line culture. About Molnupiravir.
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WHO Team Seeks to Pinpoint Source of COVID-19
The Pharma Data
DECEMBER 16, 2020
Most experts believe the severe acute respiratory syndrome coronavirus 2 virus originated in animals in China, probably bats, the Associated Press reported. Tracking down the animal in which the virus emerged will be key, so the group will take samples of further bat species and other animals that might harbor it. AP News Article.
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Health Highlights: Dec. 16, 2020
The Pharma Data
DECEMBER 16, 2020
Most experts believe the SARS-CoV-2 virus originated in animals in China, probably bats, the Associated Press reported. The objective of the 10-person WHO team is to gather information to better prepare for possible future outbreaks, according to team member Fabian Leendertz, a German biologist who specializes in emerging diseases.
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PFIZER AND BIONTECH ANNOUNCE SUBMISSION OF INITIAL DATA TO U.S. FDA TO SUPPORT BOOSTER DOSE OF COVID-19 VACCINE
The Pharma Data
AUGUST 16, 2021
Vaccination is our most effective means of preventing COVID-19 infection – especially severe disease and hospitalization – and its profound impact on protecting lives is indisputable. We continuously strive to stay at least one step ahead of the virus. today announced that they have submitted Phase 1 data to the U.S.
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CDC says nearly 11,000 Americans have been exposed to COVID-19 on flights
The Pharma Data
SEPTEMBER 21, 2020
The Centers for Disease Control and Prevention has identified nearly 11,000 people who were potentially exposed to coronavirus while flying. . Despite this, the CDC has recognised that the virus does not spread as easily on planes as other indoor settings as the air is filtered. Photo by Solitude [link].
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Deliberate Dysentery
Codon
JANUARY 21, 2024
Today, refined versions of these human challenge studies have become standard practice in testing vaccines for vector-borne diseases (e.g., yellow fever, malaria, and dengue), evaluating new drugs or treatments, and studying pathogenesis, the process by which a disease develops. How are disease targets selected for challenge trials?
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Janssen Announces Novel Mechanism of Action that Shows Promise Against Dengue in Data Published in Nature
The Pharma Data
OCTOBER 6, 2021
Data from the early-stage study suggest that an antiviral compound prevents the interaction between two viral proteins (NS3 and NS4B) that play an important role in the replication process of a virus, thereby stopping the ability of the virus to reproduce. Janssen is now moving its dengue program into clinical development.
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People’s ‘Microbiomes’ Might Influence COVID-19 Severity: Study
The Pharma Data
JANUARY 13, 2021
Siew Ng, a professor from the Institute of Digestive Disease at the Chinese University of Hong Kong. “Restoration of the missing beneficial bacteria might boost our immunity against SARS-CoV2 virus and hasten recovery from the disease,” she said. Further Support and Information on COVID-19. © 2021 HealthDay.
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New research presented at IDWeek 2021 reinforces Sanofi’s robust vaccines pipeline and commitment to advancing public health protection
The Pharma Data
SEPTEMBER 30, 2021
We anticipate to sharing developments from our leading vaccines pipeline which underscore our ongoing commitment to uncovering insights which will help prevent severe infectious diseases at every stage of life, especially in diseases with an unmet need like respiratory syncytial virus.”. In the U.S., About MenQuadfi In the U.S.,
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CDC: Travelers From the U.K. Must Have Negative COVID-19 Test
The Pharma Data
DECEMBER 28, 2020
Centers for Disease Control and Prevention said Thursday. The test is needed to guard against the spread of a new form of the virus found in the United Kingdom that may be 70 percent more contagious than other forms of COVID-19. More Information. Further Support and Information on COVID-19. MONDAY, Dec. © 2020 HealthDay.
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Clover and Dynavax Announce Planned Global Phase 2/3 Efficacy Trial of Adjuvanted COVID-19 Vaccine Candidate
The Pharma Data
JANUARY 31, 2021
” Dr. Richard Hatchett , Chief Executive Officer of CEPI, commented: “To end the acute phase of this pandemic, and to control the virus in the longer term, the world needs multiple safe and effective vaccines which can be deployed in a range of populations and countries. . EMERYVILLE, Calif. and CHENGDU, China , Feb.
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AHA News: What Heart and Stroke Patients Should Know About COVID-19 Vaccines
The Pharma Data
JANUARY 15, 2021
“People with all kinds of cardiovascular risk factors and disease should definitely get vaccinated to protect themselves and their families from COVID-19,” said Dr. Mitchell Elkind, a professor of neurology and epidemiology at NewYork-Presbyterian Hospital/Columbia University Irving Medical Center in New York City. FRIDAY, Jan.
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Scans Reveal How COVID-19 Can Harm the Brain
The Pharma Data
DECEMBER 31, 2020
31, 2020 — Blood vessel damage and inflammation in the brains of deceased COVID-19 patients suggest the damage is not caused by the virus, but the body’s immune response to it. The researchers saw no signs of the virus in the tissue samples, which they said may mean that the damage was not caused by the virus itself.
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