Drugs.com

SEPTEMBER 7, 2023

7, 2023 -- While it doesn't prevent infection altogether, new research shows the mpox vaccine does reduces the severity of disease in those who fall ill from the virus. An international team of scientists found that those people who. THURSDAY, Sept.

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Vaccine Virus International Disease 214

Broad Institute

SEPTEMBER 28, 2023

By Allessandra DiCorato September 28, 2023 Credit: Strittmatter Laboratory, Yale University Amyloid beta clusters (red) builds up among neurons (green) in a mouse model of Alzheimer’s disease. The scientists identified a suite of changes in cells unique to the early stages of Alzheimer’s, including some not seen before in animal studies.

Disease 144

Disease Medical Schools Research Hospitals 144

SCIENMAG: Medicine & Health

OCTOBER 31, 2023

New International Prize for Biomedical Research to Jean-Laurent Casanova, MD, PhD, for revolutionizing our understanding of human infectious diseases through the discovery of genetic and immunological determinants that underpin both rare and common infectious illnesses.

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International Research Disease 93

SCIENMAG: Medicine & Health

NOVEMBER 22, 2023

Anti-rheumatic drugs used for rheumatoid arthritis might prevent the development of autoimmune thyroid disease, according to a new observational study by researchers from Karolinska Institutet published in the Journal of Internal Medicine. Credit: Photo: Stefan Zimmerman Anti-rheumatic drugs used for rheumatoid arthritis might prevent the development (..)

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Disease Drugs International Research 91

Drug Target Review

DECEMBER 9, 2024

Its applications include studying disease pathology to develop targeted therapeutics, visualising enzymes that can decompose plastics, and engineering solutions to antibiotic resistance, among many others. David Baker is listed as an inventor on many patents, focused on compositions and methods for treating particular diseases.

Engineering 105

Engineering International Drug Development Science 105

Drug Target Review

OCTOBER 30, 2024

Imagine being able to create an in vitro replica of a diseased organ to study the molecular mechanism underlying the illness. Now take a step further: envision testing drugs in these organoids to identify the ones that can treat disease safely and effectively without needing to run expensive clinical trials first.

Treatment 105

Treatment Disease Clinical Trials Molecular Biology 105

SCIENMAG: Medicine & Health

DECEMBER 18, 2023

Led by Aoxing Liu and senior authors Melinda Mills, Andrea Ganna and an international team, the study examined the link between 414 early-life diseases and lifetime childlessness in over 2.5 Credit: Nature Led by Aoxing Liu and senior authors Melinda Mills, Andrea Ganna and an international team, the […]

Disease 85

Disease International 85

Broad Institute

DECEMBER 7, 2023

As reported in Nature Genetics , the work will be helpful for interpreting findings from clinical genetic testing — especially for recessive diseases, which arise when both copies of a gene are impacted by a damaging genetic variant. Tags: Medical and Population Genetics Program Rare Disease Clinical genomics Nature Genetics.

Disease 104

Disease Hospitals International Research 104

Covalent Modifiers

JANUARY 13, 2024

Thomas Kodadek Angewandte Chemie International Edition 2024 e202316726 [link] Many of the highest priority targets in a wide range of disease states are difficult-to-drug proteins.

Small Molecule 195

Small Molecule International Disease Drugs 195

Advarra

NOVEMBER 14, 2024

In an era where clinical trials are increasingly global, it’s more imperative than ever to leverage international expertise. Enhanced objectivity: A DMC composed of diverse international experts can mitigate potential biases arising from local or regional perspectives. local standards of care).

Clinical Trials 97

Clinical Trials Trials International Clinical Research 97

Broad Institute

FEBRUARY 7, 2024

However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. The team found that a key biological mechanism involved in a rare vascular disease may influence CAD risk.

Disease 105

Disease Hospitals Medical Schools Therapies 105

Drug Target Review

JULY 13, 2023

In this article, we will delve into the world of condensate biology and explore the groundbreaking research projects undertaken to discover the potential they hold for diseases such as amyotrophic lateral sclerosis ( ALS ) and colorectal cancer. Klein notes the importance of Dewpoint’s disease-agnostic approach.

Disease 98

Disease Small Molecule Cell Biology Drugs 98

Drug Target Review

JULY 7, 2023

Approximately three percent of the global population — 240 million people — experience autoantibody diseases, which occur when one’s own body attacks critical organs and tissues. This can create an abnormal immune response that attacks the cells of our bodies and contributes to the development of autoantibody diseases.

Disease 98

Disease Immune Response Therapies Treatment 98

PLOS: DNA Science

JANUARY 25, 2024

An international research team published their findings on the Mesolithic gum in Scientific Reports. The presence of DNA sequences from Treponema denticola , Streptococcus anginosus , and Slackia exigua indicate tooth decay, and from Streptococcus sobrinus and Parascardovia denticolens , periodontal disease.

Disease 98

Disease DNA Science Virus 98

SCIENMAG: Medicine & Health

JANUARY 9, 2024

Amsterdam, January 9, 2024 – The Journal of Alzheimer’s Disease (JAD), published by IOS Press, is pleased to announce the appointment of new co-Editor-in-Chief, Paula I. Moreira, PhD.

Disease 82

Disease International 82

Chemical Biology and Drug Design

JANUARY 15, 2024

Abstract This study was designed to explore the protective effect and mechanism of naringin (NG) on radiation-induced heart disease (RIHD) in rats. Our results suggest that Nar can ameliorate cardiac injury induced by x-ray exposure in dose-dependent rats by inhibiting ER stress and activation of the Sirt1/NF-κB signaling pathway.

Disease 100

Disease International Regulations Treatment 100

Perficient: Drug Development

DECEMBER 12, 2023

Women in Tech (WiT) India, in association with Perficient GDC Nagpur and Pune , celebrated International Men’s Day at both offices with great gusto. Neha Pasi , the host for the day, started the event with an introduction and shared the importance of celebrating International Men’s Day. Click to view slideshow.

International 52

International Disease 52

SCIENMAG: Medicine & Health

SEPTEMBER 1, 2023

UMC Utrecht will lead an international consortium that will try to answer a key question that’s in the mind of many pediatricians, infectiologists, pulmonologists and other health professionals: “Why are children that had an RSV infection in early childhood at increased risk of developing asthma later in life?”

Disease 84

Disease International 84

Zobio

AUGUST 26, 2024

In person ZoBio will be present in Rome for the XXVIII EFMC International Symposium on Medicinal Chemistry. The 2024 program promises to be as interesting and diverse as ever, covering significant advances in drug discovery across major therapeutic areas.

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International Disease Drugs 40

The Open Targets Blog

NOVEMBER 8, 2023

This summer, Jason Menkiti joined the Open Targets team as part of an eight-week internship through Health Data Research UK and the 10,000 Black Interns programme , which aims to provide STEM students and graduates with an experience related to improving healthcare through data research. What did your project involve?

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International Science Disease Research 63

Drug Target Review

SEPTEMBER 9, 2024

functions to reset the immune system and potentially provide remission for allergic diseases? In allergic diseases, APCs identify and present unknown antigens to the immune system. This can lead to inadequate long-term effectiveness with low rates of disease remission. They also require frequent administration.

Disease 64

Disease Immune Response Clinical Trials Treatment 64

Drug Target Review

DECEMBER 11, 2024

This shift in focus is especially critical in toxicology, where accurate target analysis plays a vital role in identifying toxic effects and ensuring patient safety, particularly as the field transitions from traditional drugs to the promising realm of biotherapeutics, especially for rare diseases.

International 52

International Laboratories Drugs Pharmacokinetics 52

Drug Target Review

OCTOBER 25, 2024

How does precision neuroscience differ from traditional approaches in the treatment of neurodegenerative diseases, and what advantages does it offer? Traditionally, Alzheimer’s disease is diagnosed by clinical examination, medical history and cognitive testing. We believe we are at a breakthrough moment in Alzheimer’s disease research.

Disease 59

Disease Clinical Trials Therapies Science 59

Drug Target Review

DECEMBER 21, 2023

Researchers at the Allen Institute for Cell Science , a division of the Allen Institute in Seattle, US, developed a unique mathematical framework to uncover internal organisation of cellular structures in human induced pluripotent stem cells (hiPSCs) while taking account of the wide range of variation that naturally occurs in cell shapes.

International 105

International Science Disease Research 105

Alta Sciences

AUGUST 21, 2024

Internships at Altasciences: Q&A With Our Summer Interns nbartlett Thu, 08/22/2024 - 04:44 Internships at Altasciences are more than just a stepping stone—they’re a gateway to real-world-experience and professional growth, giving the next generation opportunities to help shape progress in the drug development industry. The work environment.

International 40

International Laboratories Science Molecular Biology 40

Antidote

JANUARY 17, 2023

Hemophilia is a disease in which the blood does not clot properly. It is rare and typically hereditary, often leading to spontaneous or excessive bleeding, especially following injuries or surgery, and internal bleeding can be a major risk factor. Below, we’re exploring a few hemophilia facts many people may not know.

International 98

International Disease 98

Drug Target Review

MARCH 19, 2024

In the current study undertaken by an international team of researchers, co-led by Dr William Reay, we used the genetics of retinol itself as a way to proxy its effect in thousands of traits, including brain structure, vision, and the immune system through causal modelling.

Laboratories 105

Laboratories Bioinformatics International Research Laboratories 105

Conversations in Drug Development Trends

NOVEMBER 3, 2022

But for rare disease trials, which are already challenging to enroll, the new guidance introduces nuances that speak to broader recruitment trends in orphan drugs, suggested Derek Ansel, executive director, therapeutic strategy lead, rare diseases at Worldwide Clinical Trials. medical access, such as social determinants of health.

Disease 52

Disease Clinical Trials Trials International 52

Fierce BioTech

SEPTEMBER 11, 2023

Aligning cross-functional teams across the organization to ensure medical, marketing, and market access are all in lock-step is even more crucial when launching a therapy into a rare disease market. png Listing Introduction Herspiegel experts share best practices for addressing the unique aspects of successful rare disease commercialization.

Production 52

Production Disease FDA Approval Therapies 52

Drug Target Review

JANUARY 14, 2025

Based in South Africa, she has worked extensively with international biotech companies, specialising in therapeutic development for ageing-related diseases and complex conditions such as glioblastoma and autosomal dominant polycystic kidney disease (ADPKD).

Drugs 69

Drugs Protein Expression Science Research 69

Broad Institute

FEBRUARY 19, 2024

By Claire Hendershot February 19, 2024 Source: iStockPhoto An international collaboration of research teams has conducted the largest and most ancestrally diverse genome-wide association study for type 2 diabetes (T2D). DOI: 10.1038/s41586-024-07019-6 Tags: Metabolic Disease Diabetes By analyzing the DNA of 2.5 Nature Metabolism.

DNA 126

DNA Disease Research International 126

SCIENMAG: Medicine & Health

DECEMBER 11, 2023

. – University at Buffalo research has identified how a misstep in the genesis of a key component of the kidney causes infantile cystinosis, a rare disease that significantly shortens the lifespan of patients. 30 in the International Journal of Molecular Sciences, the work reveals that the mechanisms that cause the disease could […]

International 84

International Science Disease Research 84

Drug Target Review

JUNE 3, 2024

How does COUR Pharmaceuticals’ immune-modifying nanoparticle platform differ from traditional approaches to treating immune-mediated diseases? Essentially, our CNPs reprogramme the immune system by restoring balance and returning the body to a homeostatic state, offering a precise approach to treating immune-mediated diseases.

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Disease Therapies Pharmaceuticals Clinical Trials 49

SCIENMAG: Medicine & Health

FEBRUARY 28, 2024

professor of internal medicine and molecular medicine and genetics at the Wayne State University School of Medicine, and supported by the National Institutes of Health (NIH), has developed a tool to rapidly and inexpensively diagnose sarcoidosis, a chronic inflammatory disease marked by the growth of […]

International 85

International Disease Research 85

Drug Target Review

SEPTEMBER 19, 2024

Based on Nobel Prize-winning research, IRLAB has grown rapidly to become recognised and respected as a world-leader in understanding the complex neuropharmacology of CNS disorders, especially Parkinson’s disease (PD). The treatment often initially provides good symptom relief and those affected by the disease can live a largely normal life.

Disease 52

Disease Drugs Treatment Drug Development 52

Broad Institute

NOVEMBER 7, 2023

While RA therapies targeted to specific inflammatory pathways have emerged, only some patients’ symptoms improve with treatment, emphasizing the need for multiple treatment approaches tailored to different disease subtypes. They also found that patients’ CTAPs were dynamic and could change over time in response to treatment.

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Treatment RNA Hospitals Disease 96

The Pharma Data

MAY 22, 2023

WHO launches global network to detect and prevent infectious disease threats WHO and partners are launching a global network to help protect people from infectious disease threats through the power of pathogen genomics. Diseases do not respect borders: a disease threat in one country is also a threat to others.

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Disease Bioinformatics Virus Vaccine 52