Drug Target Review

AUGUST 28, 2024

What are the main challenges currently faced in the treatment of chronic liver diseases, and how does Resolution Therapeutics aim to address these challenges? Once a patient develops advanced cirrhosis/end-stage liver disease there are no specific therapies to significantly avoid major decompensations and death in the next few years.

Therapies 114

Therapies Disease Engineering Medical Schools 114

Drug Discovery World

DECEMBER 19, 2023

Developer Immusoft has received FDA Orphan Drug Designation and Rare Pediatric Disease Designation for the therapy, designated ISP-001, in this indication. MPS I is a rare, genetic disease that affects the body’s ability to produce the enzyme alpha-L-iduronidase (IDUA).

Engineering 284

Engineering Therapies Trials Medical Schools 284

Broad Institute

APRIL 2, 2024

Scientists link certain gut bacteria to lower heart disease risk By Allessandra DiCorato April 2, 2024 Breadcrumb Home Scientists link certain gut bacteria to lower heart disease risk Study finds several species of cholesterol-metabolizing bacteria in people with lower cholesterol levels.

Disease 145

Disease Medical Schools Hospitals DNA 145

Drug Discovery World

DECEMBER 6, 2023

The researchers have discovered a novel population of stem cells – marked by the Gremlin 1 gene – responsible for the progression of osteoarthritis. This new understanding could lead to a pharmaceutical treatment that reverses osteoarthritis and helps to address health outcomes associated with the disease.

Medical Schools 264

Medical Schools Clinical Trials Pharmaceuticals Trials 264

The Pharma Data

AUGUST 16, 2020

Eva Larkai, a fourth-year medical student, led the student group demanding change. A major British medical school is leading the drive to eliminate what it calls “inherent racism” in the way doctors are trained in the UK. And he says the problem is one that all UK medical schools and the wider NHS share.

Medical Schools 52

Medical Schools Doctors Government Drug Trials 52

Broad Institute

AUGUST 7, 2024

Core institute members have a major research presence at Broad, and remain full members of their home institution (MIT, Harvard University, or one of Harvard’s primary teaching hospitals). Anna Greka ’s research focuses on fundamental mechanisms of cellular dysfunction in genetic diseases with a focus on membrane proteins.

Medical Schools 90

Medical Schools Hospitals Bioinformatics Vaccine 90

Drug Discovery World

OCTOBER 13, 2023

Researchers at Harvard Medical School (HMS) in the US and the University of Oxford have developed a new artificial intelligence (AI) tool named EVEscape that can predict new viral variants before they emerge. million funding from UK Research and Innovation (UKRI). and variations of the latter including EG.5,

Vaccine 264

Vaccine Virus Medical Schools Immune Response 264

Drug Discovery World

JULY 5, 2024

Amgen has reported positive topline results from its randomised, double-blind, multicentre, placebo-controlled Phase III clinical trial evaluating the efficacy and safety of its treatment for Immunoglobulin G4-related disease (IgG4-RD). ” Amgen is now planning to file for approval in the US following results on the MITIGATE study. .

Treatment 147

Treatment Medical Schools Trials Clinical Trials 147

Drug Discovery World

SEPTEMBER 3, 2024

Semaglutide has been found to reduce the rates of all-cause death, including as a result of Covid-19, in those who are overweight or have obesity and established cardiovascular disease without diabetes. However, it has also been associated with an increase in suicidal thoughts.

Medical Schools 147

Medical Schools Trials Disease Hospitals 147

Drug Target Review

JULY 13, 2023

In recent years, a novel approach known as condensate biology has emerged, revolutionising the way researchers think about drug discovery and development. He now leads research and development (R&D) at Dewpoint. Dewpoint’s breakthrough was the realisation that certain condensates are associated with human diseases.

Disease 98

Disease Small Molecule Cell Biology Medical Schools 98

Drug Discovery World

FEBRUARY 6, 2024

Catherine Brownstein is an Assistant Professor in Pediatrics at Harvard Medical School and the Assistant Director of the Molecular Genetics Core Facility at Boston Children’s Hospital. And, once a potential target has been identified, genomics can be used to validate its role in the disease process.

Medical Schools 147

Medical Schools Clinical Trials Assay Development Hospitals 147

biobide

FEBRUARY 2, 2024

Pediatric cancers exhibit differences at the genetic level compared to the same form of adult disease, which may influence the selected treatment. How can research boost the discovery of specific therapies for childhood and adolescent cancers? This treatment was developed by performing a chemical screening on zebrafish.

Disease 59

Disease Medical Schools Pharma Companies Clinical Trials 59

Drug Discovery World

JULY 29, 2022

From immunity to metabolism to mental health, it seems like the gut microbiome has been linked to every aspect of human health and disease. A team led by researchers at HMS and the Broad has just accomplished the rare feat of connecting those dots for one important gut bacterium. Study after study had suggested that A. New doors open.

Research 130

Research Immune Response Medical Schools Disease 130

Drug Discovery World

AUGUST 25, 2023

A new study at UTHealth Houston in the US has found that several routine vaccinations are linked to a significant reduced risk of Alzheimer’s disease (AD). Paul Schulz, the Rick McCord Professor in Neurology with McGovern Medical School at UTHealth Houston, was senior author of the study.

Vaccine 130

Vaccine Medical Schools Immune Response Disease 130

Broad Institute

MARCH 8, 2024

By Claire Hendershot March 8, 2024 Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health via U.S. First author Zoë Levine is an MD-PhD candidate at Harvard Medical School and graduate student in the lab of Pardis Sabeti at the Broad.

Research 111

Research Disease Medical Schools RNA 111

Broad Institute

DECEMBER 20, 2023

In a study appearing in Nature , the researchers showed that these compounds could kill methicillin-resistant Staphylococcus aureus (MRSA) grown in a lab dish and in two mouse models of MRSA infection. This knowledge could help researchers to design additional drugs that might work even better than the ones identified by the model. “Our

Research 111

Research Engineering Medical Schools Science 111

Broad Institute

JULY 6, 2023

The accuracy of these scores has improved for some diseases and groups of people, but they continue to fall short for those of non-European ancestry, mainly because the genetic datasets used to calculate these scores have largely come from people of European ancestry.

Disease 97

Disease DNA Hospitals Medical Schools 97

Drug Discovery World

DECEMBER 5, 2022

Scientists have unlocked key insights into virus evolution, revealing new information that could help develop treatments for a wide variety of genetic diseases. . The research focuses on a group of small, ubiquitous viruses called ‘parvoviruses’ (from the Latin word ‘ parvus’ meaning ‘small’, ‘puny’ or ‘unimportant’).

Virus 130

Virus Therapies Treatment Medical Schools 130

Drug Discovery World

JANUARY 5, 2023

CANbridge Pharmaceuticals has exercised its option to secure the exclusive global rights to develop, manufacture and commercialise a novel gene therapy to treat spinal muscular atrophy (SMA) from UMass Chan Medical School. . It also exhibited much less liver toxicity when administered intravenously. .

Therapies 130

Therapies Medical Schools Clinical Development Pharmaceuticals 130

Drug Discovery World

JULY 21, 2022

Two doses of Covid-19 vaccines were sufficient in providing protection against severe cases of the infectious disease, according to new research. . The researchers used NHS health records from over 7 million adults to assess vaccine effectiveness. Bristol Medical School: Population Health Sciences (PHS)?and

Vaccine 130

Vaccine Medical Schools Hospitals Science 130

Broad Institute

JULY 26, 2022

Researchers decipher how a gut bacterium influences immunity By Corie Lok July 26, 2022 Breadcrumb Home News Researchers decipher how a gut bacterium influences immunity Study finds a molecule made by the bacterium that helps moderate immune responses. Study after study had suggested that A. muciniphila ’s cell membrane.

Research 52

Research Immune Response Medical Schools Disease 52

Drug Discovery World

MARCH 15, 2023

Researchers at the University of East Anglia have developed a new drug that works against all of the main types of primary bone cancer. First new treatment in 45 years Lead researcher Dr Darrell Green, from UEA’s Norwich Medical School, was inspired to study childhood bone cancer after his best friend died from the disease as a teenager.

Small Molecule 130

Small Molecule Medical Schools Drugs Clinical Trials 130

Broad Institute

JUNE 18, 2024

Now researchers have developed a low-cost paper strip test that could allow more patients to find out which type of flu they have and get the right treatment. Myhrvold, who is currently an assistant professor at Princeton University, was a postdoctoral researcher in Sabeti’s lab when the study began. We’re excited to apply it to H5N1.”

Virus 144

Virus RNA Medical Schools Laboratories 144

The Pharma Data

DECEMBER 3, 2020

New Tau Protein is Abnormal in Very Early Alzheimer’s Disease. Investigators with the University of Gothenburg identified new forms of tau protein that become abnormal in the very early stages of Alzheimer’s disease, even before the development of cognitive problems. Kidney Disease Leading Risk Factor for COVID-related Hospitalization.

Disease 52

Disease Research Virus Hospitals 52

Drug Discovery World

FEBRUARY 2, 2023

The Food and Drug Administration (FDA) has approved Orserdu (elacestrant) for the treatment of postmenopausal women or adult men, with ER+, HER2-, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy. Stemline Therapeutics, a wholly-owned subsidiary of the Menarini Group, will (..)

FDA Approval 130

FDA Approval FDA Therapies Medical Schools 130

Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs. The study appears in Nature Biotechnology.

RNA 98

RNA Medical Schools Engineering DNA 98

Broad Institute

AUGUST 8, 2024

at Harvard Medical School, where he conducted research with Pardis Sabeti on evolution of human genetic resistance to infectious disease. Tabrizi earned his M.D.

Medical Schools 52

Medical Schools Hospitals DNA Engineering 52

Broad Institute

AUGUST 19, 2024

A team of researchers at the Broad Institute of MIT and Harvard; the Ragon Institute of Mass General Brigham, MIT, and Harvard; and St. Jude Children’s Research Hospital have discovered that oleic acid, one of the most abundant fatty acids in the body, restores a healthy balance of vaginal microbes in a laboratory model of BV.

Hospitals 121

Hospitals Medical Schools Treatment Science 121

Drug Discovery World

JANUARY 9, 2023

In this early research, Khalid Shah, Professor of Neurosurgery at Harvard Medical School and Brigham and Women’s Hospital, and colleagues tested the vaccine in an advanced mouse model of brain cancer glioblastoma, with promising results. “Our

Medical Schools 130

Medical Schools Engineering Vaccine Therapies 130

Broad Institute

OCTOBER 16, 2023

She helps lead a team that processes a variety of sample types to support research at the institute focused on a wide range of diseases. She previously served as a flow cytometry specialist at Harvard University and as a research technician at Harvard Medical School. Rogers earned a B.S.

Medical Schools 52

Medical Schools Science Disease Research 52

KIF1A

MAY 4, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. In this week’s article, researchers in Brazil identified a KIF1A mutation in a cohort of patients with congenital ataxia.

Science 116

Science Medical Schools RNA Research 116

Drug Discovery World

NOVEMBER 23, 2023

Research that once took months to complete – requiring synthesizing and testing compounds – can now be done in days and even hours using AI. Towards personalised medicine for populations From my vantage point, we are still in the early days of understanding the value of biobanked samples and AI-models in designing new drugs.

Drugs 147

Drugs Medical Schools Trials Disease 147

Broad Institute

MARCH 8, 2024

“Type 2 diabetes is a disease of elevated blood sugar impacting approximately one in 10 people in the United States that can cause devastating health complications and is usually not cured. Udler and her colleagues assessed genetic findings from more than 1.4 Adapted from an MGH press release. Paper cited: Smith K, Deutsch AJ, McGrail C.,

Medical Schools 127

Medical Schools Hospitals Disease Therapies 127

PLOS: DNA Science

JULY 27, 2023

That information led, thanks to vaccine shelved from the first SARS circa 2003, to the rapid development and deployment of mRNA vaccines against the new infectious disease. I tracked the numbers of sequenced SARS-CoV-2 genomes posted at GISAID every few days during the pandemic, contributed by researchers everywhere.

Disease 68

Disease DNA Virus RNA 68

Broad Institute

MARCH 14, 2024

Related groups Liu lab Choudhary lab Fischer lab Researchers studying the role of proteins in health and disease use experimental tools that inactivate proteins, destroy them, or prevent them from being made in cells. PACE allows researchers to rapidly evolve new proteins that have useful features.

Targeted Protein Degradation 141

Targeted Protein Degradation Small Molecule Medical Schools Science 141

The Pharma Data

JUNE 2, 2022

Novartis today announced a partnership with the American Society of Hematology (ASH) to provide six additional African nations with technology that is already being used in Ghana to document and share the diagnosis of babies with sickle cell disease. About Sickle Cell Disease.

Disease 52

Disease Medical Schools Treatment Therapies 52

Drug Discovery World

NOVEMBER 27, 2023

As the significance of large molecules continues to broaden across diverse modalities, emphasis on bispecific and multispecific antibodies to treat various disorders such as rheumatologic diseases, cancer, diabetes, anaemia, and infectious diseases becomes paramount.

Production 147

Production Engineering Molecular Biology Drug Development 147