Broad Institute

SEPTEMBER 18, 2024

By Allessandra DiCorato September 18, 2024 Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health Colorized scanning electron micrograph of Escherichia coli, grown in culture and adhered to a cover slip. Pust is in the lab of Xavier, who is co-director of its Infectious Disease and Microbiome Program.

Medical Schools 119

Medical Schools Disease Hospitals Treatment 119

Broad Institute

AUGUST 19, 2024

A common fatty acid may help restore healthy vaginal bacteria after infection By Ari Navetta August 19, 2024 Breadcrumb Home A common fatty acid may help restore healthy vaginal bacteria after infection Treatments using oleic acid, a naturally occurring oil used in cells, could improve treatment of recurrent bacterial vaginosis infections.

Hospitals 121

Hospitals Treatment Medical Schools Science 121

biobide

FEBRUARY 2, 2024

Pediatric cancers exhibit differences at the genetic level compared to the same form of adult disease, which may influence the selected treatment. Zebrafish Pioneers Advance in Pediatric Cancer Research and Treatment Increasing the survival rate is the primary goal when screening for cancer drugs.

Disease 59

Disease Medical Schools Pharma Companies Clinical Trials 59

Broad Institute

OCTOBER 21, 2024

By Leah Eisenstadt October 21, 2024 Credit: Kevin Middleton, Broad Communications In the Bhattacharyya lab, researchers develop methods to quickly identify the most appropriate treatments for bacterial infections. The findings appear in the Journal of Clinical Microbiology.

RNA 115

RNA Hospitals Laboratories Medical Schools 115

Drug Target Review

DECEMBER 16, 2024

Dr Pooja Hingorani, Senior Medical Director of Oncology Early Development at AbbVie , shares her journey in STEM, from her early days in New Delhi to her impactful career in oncology research and drug development. My inclination toward biological sciences led me to medical school to pursue a future in STEM.

Medical Schools 52

Medical Schools Clinical Research Drug Development Trials 52

The Pharma Data

JANUARY 25, 2021

25, 2021 — Recommendations are presented for the diagnosis and management of von Willebrand disease (VWD) in two clinical guidelines issued by the American Society of Hematology, International Society on Thrombosis and Haemostasis, National Hemophilia Foundation, and World Federation of Hemophilia and published online Jan. MONDAY, Jan.

Disease 52

Disease Medical Schools Laboratories Therapies 52

Broad Institute

OCTOBER 23, 2024

They knew that discovering the genetic cause of her disorder would help them find other people like her, help get the condition formally recognized as a new disease, and help them better advocate for research into new treatments. This is the first human disease caused by loss of one copy of a lncRNA gene.

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DNA RNA Disease Hospitals 128

Broad Institute

MAY 30, 2023

By Andrea Tamayo May 30, 2023 Credit: Allison Dougherty, Broad Communications Isabella Teixeira-Soldano studies single cells to better understand disease progression. She realized the importance of her role in keeping the worms healthy, so she could later study their gene expression and behavior in response to different drug treatments.

Research 89

Research Medical Schools Doctors Science 89

Broad Institute

NOVEMBER 13, 2023

Liquid biopsies enable clinicians to find and analyze tumor DNA in a patient’s blood sample to detect cancer early, monitor cancer recurrence, assess the patient’s response to treatment, and measure other clinically important features in real time, without invasive procedures.

DNA 116

DNA Medical Schools Treatment Therapies 116

Drug Target Review

NOVEMBER 8, 2023

Cell therapies hold immense promise for revolutionising the treatment of some of the most challenging diseases, but several technological and logistical hurdles stand in the way of unlocking their full potential. By harnessing the fundamental biology of T cells, Senza5 can be used to improve the efficacy of almost any CAR-T therapy.

Therapies 116

Therapies Engineering Treatment Molecular Biology 116

Drug Target Review

AUGUST 29, 2024

However, these treatments will eventually fail for the majority of patients, so there is a strong need for better CAR therapies. How might the CD5 knockout approach impact the treatment of other types of cancers beyond T-cell lymphoma?

Therapies 59

Therapies Treatment Engineering Molecular Biology 59

Broad Institute

MARCH 8, 2024

By Claire Hendershot March 8, 2024 Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health via U.S. Levine and Siddle say that these findings could improve the precision of diagnostics and treatments in areas with high numbers of NMFI cases.

Research 111

Research Disease Medical Schools RNA 111

Broad Institute

FEBRUARY 11, 2025

Its T cells in particular are famous for their ability to attack tumors, leading to immunotherapies that have revolutionized cancer treatment. Studies of cancer immunotherapy have largely focused on T cells, but the Bod lab seeks to understand whether the immune system's antibody-producing B cells can also be leveraged for cancer treatment.

Medical Schools 52

Medical Schools Immune Response Hospitals Doctors 52

The Pharma Data

DECEMBER 15, 2020

A healthy immune system defends the body against disease and other conditions. Autoimmune disease impacts different parts of the body, weakening functionality. Researchers are aware of more than 80 diseases that occur when the immune system attacks the body’s own organs, tissues and cells. It may be life-threatening.

Disease 52

Disease Clinical Trials Small Molecule Trials 52

Drug Target Review

JULY 1, 2024

As a non-opioid, SRP-001 also eliminates abuse potential, positioning it as a safer and effective drug candidate for the treatment of acute and neuropathic pain and migraine headache. How does SRP-001’s safety profile, especially concerning hepatotoxicity and nephrotoxicity, compare to other common pain medications?

Treatment 59

Treatment Clinical Trials Therapies Molecular Biology 59

The Pharma Data

JUNE 2, 2022

Novartis today announced a partnership with the American Society of Hematology (ASH) to provide six additional African nations with technology that is already being used in Ghana to document and share the diagnosis of babies with sickle cell disease. Lurie Comprehensive Cancer Center at Northwestern University’s Feinberg School of Medicine.

Disease 52

Disease Medical Schools Treatment Therapies 52

Drug Target Review

FEBRUARY 29, 2024

During my academic career, I had the opportunity to examine the underlying causes of neurodegenerative diseases like Parkinson’s disease and develop novel animal models to investigate potential disease-modifying therapeutics. For instance, we know ageing is a primary risk factor for many neurodegenerative diseases.

Therapies 111

Therapies Disease Clinical Trials Science 111

Broad Institute

OCTOBER 23, 2024

Scientist II Michael Trembley is a scientist II at the Precision Cardiology Laboratory (PCL) of the Broad Institute and Bayer, where his research is focused on discovering and validating novel therapeutic targets for heart disease.

Medical Schools 52

Medical Schools Engineering Laboratories Doctors 52

The Pharma Data

DECEMBER 3, 2020

New Tau Protein is Abnormal in Very Early Alzheimer’s Disease. Investigators with the University of Gothenburg identified new forms of tau protein that become abnormal in the very early stages of Alzheimer’s disease, even before the development of cognitive problems. Kidney Disease Leading Risk Factor for COVID-related Hospitalization.

Disease 52

Disease Research Virus Hospitals 52

Broad Institute

AUGUST 31, 2023

Finally, we have an animal model with human-genetic validity and robust neurobiological overlap with human patients that can help scientists learn how existing treatments work and potentially help identify new ones,” said first author Zohreh Farsi, a staff scientist in the Sheng lab. “We Aug 31, 2023. DOI: 10.1016/j.neuron.2023.08.004.

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RNA Medical Schools Research Science 143

The Pharma Data

JUNE 2, 2023

With only one currently approved treatment option, I see HS patients with a tremendous need for alternatives that reduce the disabling physical symptoms of HS, improve the emotional burden and help partially avoid invasive surgery, if treating early,” said Professor Christos C.

Medical Schools 52

Medical Schools Treatment Disease Therapies 52

Broad Institute

JULY 10, 2023

Credit: Allison Colorado, Broad Communications Arriving in the Bay Area after a childhood in increasingly diverse surroundings, Martin became acutely aware of health disparities and the profound differences in disease prevalence among different populations. I wanted to know how I could have any impact on studying genetic diversity.”

Disease 98

Disease Bioinformatics Medical Schools Research 98

Broad Institute

OCTOBER 17, 2024

By Leah Eisenstadt October 17, 2024 Credit: Kevin Middleton, Broad Communications In the Bhattacharyya lab, researchers develop methods to quickly identify the most appropriate treatments for bacterial infections. The findings appear in the Journal of Clinical Microbiology (link).

RNA 69

RNA Hospitals Laboratories Medical Schools 69

The Pharma Data

JANUARY 17, 2021

Optometrists provide comprehensive eye care, including evaluations for glasses and contact lenses and common eye diseases. Ophthalmologists are physicians who have completed four years of medical school and four years of residency training. They can also treat acute eye problems such as pink eye or sties.

Medical Schools 52

Medical Schools Doctors Treatment Disease 52

The Pharma Data

SEPTEMBER 18, 2020

Promising Phase 2 data has been released at the European Society for Medical Oncology (ESMO) Virtual Congress 2020 for Sanofi and Regeneron’s jointly-developed PD-1 inhibitor Libtayo (cemiplimab) in the treatment of locally advanced basal cell carcinoma (BCC) in patients for whom hedgehog inhibitor (HHI) therapy is not applicable.

Medical Schools 52

Medical Schools Trials Therapies Hospitals 52

The Pharma Data

MARCH 13, 2021

Further, prespecified exploratory analyses showed donanemab slowed the accumulation of tau across key brain regions in patients affected by Alzheimer’s disease. “This is the first late-stage study in Alzheimer’s disease to meet its primary endpoint at the primary analysis.

Disease 40

Disease Trials Treatment Medical Schools 40

The Pharma Data

NOVEMBER 22, 2020

The mice who received the treatment had double the life expectancy as their counterparts, with a 30% higher survival rate. Peer stated that his team plans to develop a treatment for all cancers and that their technique could be ready for humans within the next two years. ” Source link.

DNA 52

DNA Medical Schools Treatment Science 52

On Medicine

APRIL 6, 2023

I have a background in Biomedical Engineering prior to medical school and a particular interest in global health and healthcare in resource-limited settings. I continued working in this field and I did my PhD thesis on anthracycline-induced cardiotoxicity during and after treatment for childhood cancer.

Medical Schools 52

Medical Schools Hospitals Treatment International 52

Advarra

FEBRUARY 28, 2023

Rebecca Lee Crumpler Rebecca Lee Crumpler was one of the first African American women to graduate from medical school and to practice medicine. Crumpler’s focus on the care of women and children and her dedication to research led her to publish “A Book of Medical Discourses” in 1883. Public Health Service.

Medical Schools 52

Medical Schools Laboratories Clinical Research Treatment 52

The Pharma Data

NOVEMBER 30, 2020

It’s a simple concept: After a health care provider explains various details on treatment plans, medications and how to manage the disease at home, they then ask the patient to repeat back the information. Data came from the 2011-2016 Medical Expenditure Panel Survey administered by the U.S.

Doctors 52

Doctors Medical Schools Hospitals Disease 52

Alta Sciences

MARCH 27, 2024

As if that isn’t enough, she is also working toward her PhD, with research focusing on the impact of supramental awareness on disease prevention, healing, and health. I started researching natural treatments and discovered an exceptional data set in the public domain that guided many of my own treatment choices over the years.

Drug Development 52

Drug Development Medical Schools Pharma Companies Drugs 52

NIH Director's Blog: Drug Discovery

DECEMBER 9, 2014

Tanzi, Massachusetts General Hospital/ Harvard Medical School Researchers want desperately to develop treatments to help the more than 5 million Americans with Alzheimer’s disease and the millions more at risk. The answer appears to lie in their decision to add a third dimension to their disease model.

Drugs 52

Drugs Disease Hospitals Medical Schools 52

DrugBank

FEBRUARY 12, 2025

This approach capitalizes on prior investments in R&D, mitigates risk by leveraging established safety and pharmacokinetic profiles, and accelerates the delivery of treatments to patients. For example, researchers utilized gene expression data to determine the anti-ulcer drug cimetidine as a possible treatment for colorectal cancer.

Cell Based Assays 52

Cell Based Assays Drugs Pharmacokinetics Disease 52

Broad Institute

JULY 20, 2023

It's clear that new technologies, analytic techniques and models of disease are needed that can accommodate the polygenic background influences on even penetrant disease alleles before we can hope to gain greater understanding of pathological mechanisms. Please register at broad.io/stanleysymposium Please register at broad.io/stanleysymposium

Medical Schools 52

Medical Schools Hospitals DNA Disease 52

NIH Director's Blog: Drug Development

APRIL 2, 2020

With so much information swirling around these days about the coronavirus disease 2019 (COVID-19) pandemic, it would be easy to miss one of the most interesting and significant basic science reports of the past few weeks. Credit: Adapted from Yan R., Science, 2020. The team, led by Scott D.

Drug Development 52

Drug Development Drugs Science Medical Schools 52

Drug Target Review

FEBRUARY 26, 2024

Rather than solely identifying tumour-associated mutations which can be specifically targeted for effective treatment, we now need to consider how non-mutational events play into both the development of the primary tumour and the development of therapy resistance.

Therapies 59

Therapies Molecular Biology Medical Schools Regulations 59

Broad Institute

AUGUST 4, 2022

By Tracy Hampton August 4, 2022 Credit: National Institutes of Allergy and Infectious Diseases, National Institutes of Health Colorized scanning electron micrograph of a B cell lymphocyte from a human donor.

Bioinformatics 52

Bioinformatics Medical Schools Hospitals Treatment 52