The Pharma Data

MAY 15, 2023

CHMP Adopts Positive Opinion Recommending Hepcludex® (Bulevirtide) for Full Marketing Authorization for the Treatment of Hepatitis Delta Virus (HDV) Gilead Sciences, Inc. People living with HDV have had very limited treatment options and without treatment, they often rapidly progress to severe liver disease or liver cancer. In the U.S.

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The Pharma Data

DECEMBER 3, 2020

New Tau Protein is Abnormal in Very Early Alzheimer’s Disease. Investigators with the University of Gothenburg identified new forms of tau protein that become abnormal in the very early stages of Alzheimer’s disease, even before the development of cognitive problems. Kidney Disease Leading Risk Factor for COVID-related Hospitalization.

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Disease Research Virus Hospitals 52

The Pharma Data

DECEMBER 5, 2020

5, 2020 — A pair of new gene therapies promise a potentially lasting cure for sickle cell disease by subtly altering the genetic information in patients’ bone marrow cells, researchers report. She’s a pediatric hematology-oncology specialist at Cohen Children’s Medical Center in New Hyde Park, N.Y.

Therapies 52

Therapies Disease Medical Schools Virus 52

Drug Target Review

MAY 16, 2024

The body’s ability to maintain homeostasis in chronic inflammatory and autoimmune diseases is a defining feature of good health, and a goal is largely neglected by modern medicine. This suggests that the field of drug discovery is primed for a paradigm shift in the fundamental strategy of how diseases are treated.

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Disease Medical Schools Therapies Treatment 64

The Pharma Data

NOVEMBER 17, 2021

Every day, hundreds of thousands of new COVID-19 cases and thousands of new deaths are still being reported worldwide, creating a need for drugs that can combat the disease caused by SARS-CoV-2. If disulfiram’s effect against SARS-CoV-2 is confirmed, it could become a useful tool against the virus. A Pandemic Pivot.

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Virus Drugs Clinical Trials Medical Schools 52

Drug Target Review

DECEMBER 28, 2023

Patients with high numbers of clonal neoantigens show improved disease-free survival. Sergio holds a PhD from Dartmouth Medical School and from 2004 to 2010 he held a post-doctoral position at Memorial Sloan-Kettering Cancer Center. Our immune system helps us to fight off infections and cancer.

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Bioinformatics Immune Response DNA Vaccine 105

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Now, a team of MIT, Massachusetts General Hospital (MGH), Broad Institute of MIT and Harvard, and Harvard Medical School (HMS) researchers has discovered how STING activates those two pathways.

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Regulations Engineering Clinical Trials DNA 91

NIH Director's Blog: Drug Development

APRIL 2, 2020

With so much information swirling around these days about the coronavirus disease 2019 (COVID-19) pandemic, it would be easy to miss one of the most interesting and significant basic science reports of the past few weeks. ACE2 is the receptor that the virus uses to gain entry. Credit: Adapted from Yan R., Science, 2020.

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Drug Development Drugs Medical Schools Science 52

The Pharma Data

JANUARY 3, 2021

The clinical study was completed in collaboration with scientific teams at the Harvard Medical School (Boston, USA), Santa Casa de Misericórdia de Santos Hospital (Santos, Brazil) and INTRIALS, a world-class, full-service Latin American CRO based in São Paulo, Brazil. . NEW YORK and LONDON, Jan. NEW YORK and LONDON, Jan.

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Clinical Trials Science Treatment Trials 40

The Pharma Data

NOVEMBER 1, 2020

Highly innovative first-in-class study for treating COVID-19 disease with nasally administered drug. Trial facilitated with coll a boration of Harvard Medical School and one of the world’s top Neurologist, Dr. Howard Weiner. Clinical Data Expected by End of Year. NEW YORK and LONDON, Nov.

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Clinical Trials Trials Medical Schools Hospitals 52

Broad Institute

JANUARY 30, 2024

Bhattacharyya wears many coats today, splitting his time between the Broad and the infectious disease ward at MGH, where a diagnostic method he developed at Broad is now being tested to see if it helps patients quickly receive the best antibiotics for their infections.

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Hospitals Medical Schools Virus Science 137

Drug Discovery World

OCTOBER 28, 2022

By blocking HIV’s entry into human CD4+ cells, the virus is unable to replicate, and the HIV transmission process may be prevented. . N6LS is a bNAb that works by binding to a specific site (gp120) on the surface of HIV that prevents its entry into immune system cells (CD4+ T-cells).

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Trials Medical Schools Virus Treatment 130

Drug Target Review

JANUARY 15, 2024

Each T cell expresses a TCR specific for an HLA‑presented peptide signal, and when that signal is detected a T cell expressing the relevant TCR can launch a complex array of immune effector responses that can suppress or destroy tumours or virus-infected cells. References Robinson R, McMurran C, McCully M, Cole D.

Engineering 110

Engineering DNA Virus Medical Schools 110

Drug Discovery World

OCTOBER 5, 2022

We are seeing game-changing developments in connected and personalised medicine that harness the power of artificial intelligence for drug design, multidimensional health data analysis and disease prediction, which will enable us to make the healthcare of the future a reality.

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Science Medical Schools Engineering Research 130

The Pharma Data

DECEMBER 15, 2020

A healthy immune system defends the body against disease and other conditions. Autoimmune disease impacts different parts of the body, weakening functionality. Researchers are aware of more than 80 diseases that occur when the immune system attacks the body’s own organs, tissues and cells. It may be life-threatening.

Disease 52

Disease Clinical Trials Small Molecule Trials 52

Broad Institute

MAY 30, 2023

By Andrea Tamayo May 30, 2023 Credit: Allison Dougherty, Broad Communications Isabella Teixeira-Soldano studies single cells to better understand disease progression. I told him I was struggling with my classes and that I didn’t think I'd make it to medical school. And if I did, I wouldn’t be happy.

Research 89

Research Medical Schools Doctors Science 89

Broad Institute

DECEMBER 6, 2023

Cytokines are also targeted by drugs for many diseases such as rheumatoid arthritis, COVID-19, and cancer, but until now, scientists haven’t had a comprehensive view of how different immune cells respond to different cytokines because the immune system is so complex. For many immune-mediated diseases, there's no cure or treatment.

Immune Response 138

Immune Response RNA Medical Schools Disease 138

The Pharma Data

JANUARY 24, 2021

The newly identified anti-COVID-19 Spike protein VNARs block infection of the virus (in live viral assays) at doses as low as 200 pM, equivalent to the best reported antibodies and much better than many. We then screened these for VNAR binders that block viral infection, and are delighted with the outcomes.”

Research 52

Research Virus Medical Schools Government 52

Drug Target Review

FEBRUARY 15, 2024

Since the 20 th century, all known viral pandemics, including HIV, influenza, SARS CoV-1, SARS, CoV-1, and mpox, have resulted from a virus ‘spilling over’ from animals into humans. For example, scientists cannot accurately predict which town or village will have the next Nipah virus outbreak.

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Drug Development Virus Vaccine Government 122

The Pharma Data

OCTOBER 15, 2020

The award honors McHutchison’s work in developing life-changing and curative therapies for patients with the hepatitis C virus. Sabbagh will be responsible for expanding Inozyme’s proprietary pipeline by identifying and developing new therapeutics for monogenic and non-genetic diseases of abnormal mineralization.

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Pharmaceuticals Clinical Pharmacology Medical Schools Vaccine 52

Codon

JUNE 26, 2023

A phage is a virus that infects bacteria. The animals had a common disease variant, caused by a single amino acid substitution in the phenylalanine hydroxylase enzyme. But LLMs will greatly increase the number of people who could make or distribute a virus. ” Bacteriophages infect a bacterium. Let me explain.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

A phage is a virus that infects bacteria. The animals had a common disease variant, caused by a single amino acid substitution in the phenylalanine hydroxylase enzyme. But LLMs will greatly increase the number of people who could make or distribute a virus. ” Bacteriophages infect a bacterium. Let me explain.

DNA 52

DNA Therapies Engineering Clinical Trials 52

The Pharma Data

DECEMBER 22, 2020

National Institute of Allergy and Infectious Diseases, said Monday. ” Some infectious disease experts said Monday the variant may not have even originated in Britain, the Post reported. The United States does not have nearly the same level of virus surveillance, the newspaper said. “It may very well be here.

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Packaging Vaccine Government Hospitals 52

The Pharma Data

DECEMBER 23, 2020

. “We don’t know that for absolutely certain, but it is reasonable to assume that is going on,” Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said Monday. The United States has lagged in sequencing and does not have nearly the same level of virus surveillance, the newspaper said.

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Vaccine Government Virus Medical Schools 52

The Pharma Data

DECEMBER 29, 2020

” With more than 19 million COVID-19 cases in the United States by Tuesday and more than 335,000 Americans now killed by the disease, more people than ever have now been personally affected by the new coronavirus. National Institute of Allergy and Infectious Diseases, said last week. “It may very well be here.

Clinical Trials 52

Clinical Trials Vaccine Trials Medical Schools 52

The Pharma Data

DECEMBER 28, 2020

” With more than 19 million COVID-19 cases in the United States by Monday and more than 333,000 Americans now killed by the disease, more people than ever have now been personally affected by the new coronavirus. National Institute of Allergy and Infectious Diseases, said last week. “It may very well be here.

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Vaccine Government Virus Medical Schools 52